Brian V. Tsu
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View article: A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification Open
View article: Reply to Redmond and McLysaght: Uncertainty in the origin of amphioxus IRBP homologs
Reply to Redmond and McLysaght: Uncertainty in the origin of amphioxus IRBP homologs Open
We introduce an intuitive particle-based model of time-symmetric quantum physics that gives a concrete description of what goes on in the time between projective measurements of a quantum system. The time-symmetry in this model means that …
View article: Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome Open
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL pro ) encoded…
View article: Bacterial origin of a key innovation in the evolution of the vertebrate eye
Bacterial origin of a key innovation in the evolution of the vertebrate eye Open
The vertebrate eye was described by Charles Darwin as one of the greatest potential challenges to a theory of natural selection by stepwise evolutionary processes. While numerous evolutionary transitions that led to the vertebrate eye have…
View article: Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL Open
Viruses interact with the intracellular transport machinery to promote viral replication. Such host–virus interactions can drive host gene adaptation, leaving signatures of pathogen-driven evolution in host genomes. Here, we leverage these…
View article: Author response: Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
Author response: Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Viruses i…
View article: Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome Open
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL pro ) encoded…
View article: Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL
Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL Open
Viruses interact with the intracellular transport machinery to promote viral replication. Such host-virus interactions can drive host gene adaptation, leaving signatures of pathogen-driven evolution in host genomes. Here we leverage these …
View article: Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune System
Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune System Open
Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode protease…
View article: Author response: Diverse viral proteases activate the NLRP1 inflammasome
Author response: Diverse viral proteases activate the NLRP1 inflammasome Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The NLRP1 inflammasome is a m…
View article: Diverse viral proteases activate the NLRP1 inflammasome
Diverse viral proteases activate the NLRP1 inflammasome Open
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-termin…
View article: Diversification of the Caenorhabditis heat shock response by Helitron transposable elements
Diversification of the Caenorhabditis heat shock response by Helitron transposable elements Open
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during…
View article: Author response: Diversification of the Caenorhabditis heat shock response by Helitron transposable elements
Author response: Diversification of the Caenorhabditis heat shock response by Helitron transposable elements Open
View article: The Transporter Classification Database (TCDB): recent advances
The Transporter Classification Database (TCDB): recent advances Open
The Transporter Classification Database (TCDB; http://www.tcdb.org) is a freely accessible reference database for transport protein research, which provides structural, functional, mechanistic, evolutionary and disease/medical information …
View article: The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis
The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis Open
The LysE superfamily consists of transmembrane transport proteins that catalyze export of amino acids, lipids and heavy metal ions. Statistical means were used to show that it includes newly identified families including transporters speci…