Brian Wasita
YOU?
Author Swipe
View article: Repurposing halofuginone derivatives for osteoarthritis therapy: Structural insights, multi-target inhibition, and pharmacokinetic profiling
Repurposing halofuginone derivatives for osteoarthritis therapy: Structural insights, multi-target inhibition, and pharmacokinetic profiling Open
Osteoarthritis is a degenerative joint disease characterized by progressive cartilage degradation, leading to pain and reduced mobility. This study employed a computational approach to explore the therapeutic potential of halofuginone and …
View article: The Role of Bleeding History: Mortality Risk Acute Leukimia
The Role of Bleeding History: Mortality Risk Acute Leukimia Open
Acute leukemia is a malignant hematological disease with a low survival rate. The survival rate of acute leukemia patients is influenced by several factors, one of which is a history of bleeding. This study aimed to evaluate whether a hist…
View article: Bibliometric mapping of secretomes, exosomes, and extracellular vesicles in Alzheimer’s disease
Bibliometric mapping of secretomes, exosomes, and extracellular vesicles in Alzheimer’s disease Open
Context: Alzheimer’s Disease (AD) is a neurodegenerative disorder with limited treatment options, primarily addressing symptoms without targeting underlying mechanisms. Emerging therapies involving secretomes, exosomes, and extracellular v…
View article: Therapeutic Potential of Ethyl Acetate Fraction of Purple Sweet Potato (Ipomoea Batatas var. Ayamurasaki) in Inhibiting Airway Remodeling through Regulation of IL-33, Periostin, IgE and TGF-β in A Chronic Asthma Model
Therapeutic Potential of Ethyl Acetate Fraction of Purple Sweet Potato (Ipomoea Batatas var. Ayamurasaki) in Inhibiting Airway Remodeling through Regulation of IL-33, Periostin, IgE and TGF-β in A Chronic Asthma Model Open
Asthma is one of the most common non-communicable diseases (NCDs) affecting children, with about 1 in 10 children suffering from this condition. This disease causes a significant morbidity burden, including affecting children’s school atte…
View article: IN SILICO STUDY OF BASELLA ALBA BIOACTIVE COMPOUNDS AS POTENTIAL THERAPY FOR PSORIASIS AGAINST TUMOR NECROSIS FACTOR-α (TNF-α) RECEPTOR
IN SILICO STUDY OF BASELLA ALBA BIOACTIVE COMPOUNDS AS POTENTIAL THERAPY FOR PSORIASIS AGAINST TUMOR NECROSIS FACTOR-α (TNF-α) RECEPTOR Open
Objective: This in silico study aims to explore the bioactive compound of Basella alba as a potential natural alternative by examining its molecular interactions with Tumor Necrosis Factor-α (TNF-α) receptors. While established biological …
View article: Effects of Alpinia galanga and prednisone on biomarkers and fetal development in asthmatic pregnancy: A rat model study
Effects of Alpinia galanga and prednisone on biomarkers and fetal development in asthmatic pregnancy: A rat model study Open
Background : The combination of asthma and pregnancy worsens placental function and fetal growth, with severe asthma increasing the risk of maternal and fetal hypoxia. Maternal hypoxia disrupts placental blood flow, reducing oxygen and nut…
View article: The Effect of Moringa Oleifera Ethanol Extract on Improving Cisplatin Induced Liver Cells Damages
The Effect of Moringa Oleifera Ethanol Extract on Improving Cisplatin Induced Liver Cells Damages Open
M. oleifera exhibits a dose-dependent ability to mitigate inflammation, oxidative stress, and liver cell damage caused by cisplatin. The pre-treatment regimen with M. oleifera was the most effective.
View article: Ovalbumin-Induced Chronic Asthma in Female Wistar Rats: Eosinophilic Infiltration, IL-5 Profiles and Bronchial Histopathology
Ovalbumin-Induced Chronic Asthma in Female Wistar Rats: Eosinophilic Infiltration, IL-5 Profiles and Bronchial Histopathology Open
Asthma, a chronic inflammatory airway disease, is marked by bronchial hyper responsiveness, airway inflammation, and remodeling, leading to symptoms such as wheezing, chest tightness, and cough, which may result in permanent lung function …
View article: The Protective Role of Astaxanthin Against Oxidative Stress and Inflammation in Peritoneal Dialysis Rats
The Protective Role of Astaxanthin Against Oxidative Stress and Inflammation in Peritoneal Dialysis Rats Open
This study found that AST supplementation might prevent peritoneal fibrosis by decreasing MDA, TGF-β, and IL-1β, as well as increasing SOD levels in serum.
View article: The effect of Abelmoschus esculentus Ethanol Extract on TNF-α expression in wound healing of diabetic: implications for physical recovery
The effect of Abelmoschus esculentus Ethanol Extract on TNF-α expression in wound healing of diabetic: implications for physical recovery Open
Introduction: For the wound healing process, the role of pro-inflammatory mediators such as Tumor Necrotic factor (TNF-α) and Interleukin-1. TNF-α is a pro-inflammatory mediator produced by macrophages that stimulates inflammatory cells, f…
View article: Effects of Moringa oleifera extract on inflammaging markers, muscle mass, and physical endurance in geriatric mice model
Effects of Moringa oleifera extract on inflammaging markers, muscle mass, and physical endurance in geriatric mice model Open
A comprehensive approach to managing frailty is required due to the increasing number of elderly. Physical frailty, associated with inflammatory processes and a loss of muscle mass, can significantly impair health status. The aim of this s…
View article: Modulation of Oxidative Stress Markers and Inflammatory Mediators in Alveolar Damage Induced by Anaerobic Exercise
Modulation of Oxidative Stress Markers and Inflammatory Mediators in Alveolar Damage Induced by Anaerobic Exercise Open
Anaerobic exercise, characterized by high-intensity, short-duration physical activity, induces a unique physiological response that includes oxidative stress and inflammation. This study investigates the modulation of oxidative stress mark…
View article: Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model
Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model Open
BACKGROUND: Oxidative stress and inflammation contribute to pancreatic cell dysfunction that promote insulin resistance in type 2 diabetes (T2D). Red rice bran contains bioactive substances with anti-inflammatory and antioxidant properties…
View article: Utilizing secretomes as a novel molecular-based therapy for Parkinson’s disease: A scoping review
Utilizing secretomes as a novel molecular-based therapy for Parkinson’s disease: A scoping review Open
Parkinson’s disease (PD) is a neurodegenerative disorder that affects multiple body systems and results in a variety of motor and non-motor symptoms. Recent research has highlighted the importance of secretome, a diverse array of bioactive…
View article: Effect of Phenol and Saponin on Apis Dorsata Forest Honey and docking molecule on preeclamptic markers
Effect of Phenol and Saponin on Apis Dorsata Forest Honey and docking molecule on preeclamptic markers Open
Molecular docking is an important computational method for drug design. It can be used to predict receptor binding interactions with ligans. In addition, phenol-derived compounds and Saponins are also reported to have various activities su…
View article: Effect of Ethanol Extract of Okra Fruit on NF-ΚB Expression in Wound Healing Wistar Rats With Diabetes Mellitus
Effect of Ethanol Extract of Okra Fruit on NF-ΚB Expression in Wound Healing Wistar Rats With Diabetes Mellitus Open
Objectives:The main objective of the study was to see the effect of Okra Fruit Ethanol Extract on NF-κB Expression in the Healing of Wistar Rat Wounds in the Diabetes Mellitus Model. Theoretical Framework: NF-κB is a critical component in …
View article: The effect of protein intake, physical activity and gender on cognitive function in the elderly at Surakarta Health Center
The effect of protein intake, physical activity and gender on cognitive function in the elderly at Surakarta Health Center Open
The prevalence of cognitive function impairment increased from 2010 to 2020. Cognitive function declines in the form of memory, language, and action disorders. Cognitive function can be prevented by consuming protein and engaging in physic…
View article: Mesenchymal stem cell secretome decreases inflammation in sepsis model
Mesenchymal stem cell secretome decreases inflammation in sepsis model Open
Aims: To determine the impact of MSC secretome on the nuclear factor-kappa B (NF-kB) expression in the liver. Methods: This research is a posttest-only control design group experimental study. This experiment used 40 mice. There were eight…
View article: Effect of chitosan nanoparticles from red snapper scales (Lutjanus sp.) on pulp repair: In vivo study
Effect of chitosan nanoparticles from red snapper scales (Lutjanus sp.) on pulp repair: In vivo study Open
Context: Iatrogenic actions leading to exposed pulp can result in pulp inflammation, with Reversible Pulpitis being a common condition among the general population. Pulp capping treatments are essential for supporting pulp repair and promo…
View article: The effects of acupuncture and methylprednisolone on cortisol levels in mice with lupus nephritis model
The effects of acupuncture and methylprednisolone on cortisol levels in mice with lupus nephritis model Open
Context: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the involvement of multisystemic and diverse autoantibodies in target cell components. One clinical manifestation of SLE is lupus nephritis. Acupuncture …
View article: Structural Comparison of Hydroxyapatite from Clam Shell Waste and Eggshell Waste Compared to Commercial Synthetic Hydroxyapatite
Structural Comparison of Hydroxyapatite from Clam Shell Waste and Eggshell Waste Compared to Commercial Synthetic Hydroxyapatite Open
Clam shell waste and eggshells can be an alternative source of hydroxyapatite substitution, as demonstrated by the structural and porous formation of hydroxyapatite obtained from these sources (CW-HAP and EW-HAP) when compared to commercia…
View article: Antioxidant activity of self-nanoemulsifying drug delivery system (SNEDDS) of Curcuma longa in polycystic ovary syndrome rat model
Antioxidant activity of self-nanoemulsifying drug delivery system (SNEDDS) of Curcuma longa in polycystic ovary syndrome rat model Open
Purpose: To investigate the effect of SNEDDS containing Curcuma longa extract on hormonal and histological improvement of polycystic ovary syndrome (PCOS) rat model. Method: A total of 36 female Wistar rats, aged between 8 and 10 weeks, we…
View article: Male Sprague Dawley Rats with Type 2 Diabetes Mellitus and Obesity on Body Weight, Body Mass Index, and Fat Content as Affected by Alkaloid Fraction of Litsea Glutinosa Leaves (AFLG)
Male Sprague Dawley Rats with Type 2 Diabetes Mellitus and Obesity on Body Weight, Body Mass Index, and Fat Content as Affected by Alkaloid Fraction of Litsea Glutinosa Leaves (AFLG) Open
There were 463 million people living with diabetes around the world, and it is expected to increase by 48% in 2045. Dipeptidyl Peptidase 4 (DPP4) inhibitor is asecond-line anti-diabetic drug, that frequently causes weight gain for long ter…
View article: Aerobic exercise improves spatial memory in a rat model of meningitis
Aerobic exercise improves spatial memory in a rat model of meningitis Open
Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from …
View article: Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model
Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model Open
Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, Phyllanthus niruri is recognized for its pharmacological effects, which might be benef…
View article: Potential of avocado oil (Persea americana) in improving triglyceride and High Density Lipoprotein (HDL) levels in rats (Rattus novergicus) model of dyslipidaemia due to high fat diet
Potential of avocado oil (Persea americana) in improving triglyceride and High Density Lipoprotein (HDL) levels in rats (Rattus novergicus) model of dyslipidaemia due to high fat diet Open
Background: Elevated levels of Dyslipidaemia pose a significant threat to cardiovascular health. Fortunately, the abundance of polyunsaturated and monounsaturated fatty acids (PUFA and MUFA) present in avocado oil offers a promising avenue…
View article: Cisplatin-Induced Oral Mucositis Prevention: Nigella sativa’s Anti-Inflammatory Role through NFκB Pathway
Cisplatin-Induced Oral Mucositis Prevention: Nigella sativa’s Anti-Inflammatory Role through NFκB Pathway Open
Prevention of Cisplatin-induced oral mucositis (OM) Presents substantial challenges due to its association with oxidative stress, inflammation, apoptosis and NFκB pathway activation. This study aims to evaluate the potential of Nigella sat…
View article: Determination of Levels of Phytochemical Compounds (Saponins, Alkaloids, Tannins) In Ripe Fiber Extract of Palmyra Fruit (Borassus flabellifer Linn)
Determination of Levels of Phytochemical Compounds (Saponins, Alkaloids, Tannins) In Ripe Fiber Extract of Palmyra Fruit (Borassus flabellifer Linn) Open
Palmyra fruit (Borassus flabellifer L.) is one of the palm tree family that can be utilized as a source of of food. It also possess numerous benefits in medicinal applications, including secondary metabolites in the form of alkaloids, flav…