Brian Zenger
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View article: Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns
Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns Open
Predictive models and computational simulations of cardiac electrophysiology depend on precise anatomical representations, including the local myocardial fibre structure. However, obtaining patient‐specific fibre information is challenging…
View article: Performance of off-the-shelf machine learning architectures and biases in low left ventricular ejection fraction detection
Performance of off-the-shelf machine learning architectures and biases in low left ventricular ejection fraction detection Open
View article: Comprehensive analysis of same day discharge after atrial fibrillation ablation: Clinical, cost, and patient reported outcomes
Comprehensive analysis of same day discharge after atrial fibrillation ablation: Clinical, cost, and patient reported outcomes Open
Background Same day discharge (SDD) following atrial fibrillation (AF) ablation procedure has emerged as routine practice, and primarily driven by operator discretion. However, the impacts of SDD on clinical outcomes, healthcare system cos…
View article: Characteristics of a transgender and gender-diverse patient population in Utah: Use of electronic health records to advance clinical and health equity research
Characteristics of a transgender and gender-diverse patient population in Utah: Use of electronic health records to advance clinical and health equity research Open
Transgender and gender-diverse (TGD) people, individuals whose gender identity differs from their sex assigned at birth, face unique challenges in accessing gender-affirming care and often experience disparities in a variety of health outc…
View article: Comparison of Machine Learning Detection of Low Left Ventricular Ejection Fraction Using Individual ECG Leads
Comparison of Machine Learning Detection of Low Left Ventricular Ejection Fraction Using Individual ECG Leads Open
The 12-lead electrocardiogram (ECG) is the most common front-line diagnosis tool for assessing cardiovascular health, yet traditional ECG analysis cannot detect many diseases. Machine learning (ML) techniques have emerged as a powerful set…
View article: Uncertainty Quantification of the Effect of Variable Conductivity in Ventricular Fibrotic Regions on Ventricular Tachycardia
Uncertainty Quantification of the Effect of Variable Conductivity in Ventricular Fibrotic Regions on Ventricular Tachycardia Open
Ventricular tachycardia (VT) is a life-threatening cardiac arrhythmia for which a common treatment pathway is electroanatomical mapping and ablation. Recent advances in both noninvasive ablation techniques and computational modeling have m…
View article: Characteristics of Transgender and Gender Diverse Adults pursuing Gender Affirming Hormone Therapy and Surgery
Characteristics of Transgender and Gender Diverse Adults pursuing Gender Affirming Hormone Therapy and Surgery Open
CONTEXT: People who identify as transgender or gender diverse (TGD) are a growing demographic with unique healthcare needs. There are calls for action to increase the visibility and needs of this community, particularly as systemic barrier…
View article: Uncertainty quantification of the effect of cardiac position variability in the inverse problem of electrocardiographic imaging
Uncertainty quantification of the effect of cardiac position variability in the inverse problem of electrocardiographic imaging Open
Objective. Electrocardiographic imaging (ECGI) is a functional imaging modality that consists of two related problems, the forward problem of reconstructing body surface electrical signals given cardiac bioelectric activity, and the invers…
View article: Commentary: All models are wrong, but some are useful: understanding cognitive decline and dementia in atrial fibrillation through vascular computational modelling
Commentary: All models are wrong, but some are useful: understanding cognitive decline and dementia in atrial fibrillation through vascular computational modelling Open
Atrial fibrillation (AF) has been clearly shown to be an independent risk factor for cognitive decline and dementia.1, 2 However, the exact mechanism that causes this precipitous cognitive decline is unknown.1 Some of the most unmistakable…
View article: Performance of Off-the-Shelf Machine Learning Architectures and Biases in Detection of Low Left Ventricular Ejection Fraction
Performance of Off-the-Shelf Machine Learning Architectures and Biases in Detection of Low Left Ventricular Ejection Fraction Open
1 Abstract Artificial intelligence - machine learning (AI-ML) is a computational technique that has been demonstrated to be able to extract meaningful clinical information from diagnostic data that are not available using either human inte…
View article: DH-452784-3 “OFF-THE-SHELF” OPEN SOURCE MACHINE LEARNING ARCHITECTURES CORRECTLY IDENTIFY PATIENTS WITH LOW EF USING ECG ALONE
DH-452784-3 “OFF-THE-SHELF” OPEN SOURCE MACHINE LEARNING ARCHITECTURES CORRECTLY IDENTIFY PATIENTS WITH LOW EF USING ECG ALONE Open
View article: This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment
This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment Open
AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or …
View article: Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models
Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models Open
The study of cardiac electrophysiology is built on experimental models that span all scales, from ion channels to whole-body preparations. Novel discoveries made at each scale have contributed to our fundamental understanding of human card…
View article: Statistical shape modeling of multi-organ anatomies with shared boundaries
Statistical shape modeling of multi-organ anatomies with shared boundaries Open
Introduction: Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis of shapes and their variations. SSM applies mathematics, statistics,…
View article: Heart Position Uncertainty Quantification in the Inverse Problem of ECGI
Heart Position Uncertainty Quantification in the Inverse Problem of ECGI Open
Electrocardiographic imaging (ECGI) is a clinical and research tool for noninvasive diagnosis of cardiac electrical dysfunction.The position of the heart within the torso is both an input and common source of error in ECGI.Many studies hav…
View article: A Sliding Window Approach to Regularization in Electrocardiographic Imaging
A Sliding Window Approach to Regularization in Electrocardiographic Imaging Open
Introduction:The inverse problem of ECGI is ill-posed, so regularization must be applied to constrain the solution.Regularization is typically applied to each individual time point (instantaneous) or to the beat as a whole (global).These t…
View article: Unexpected Errors in the Electrocardiographic Forward Problem
Unexpected Errors in the Electrocardiographic Forward Problem Open
Previous studies have compared recorded torso potentials with electrocardiographic forward solutions from a pericardial cage.In this study, we introduce new comparisons of the forward solutions from the sock and cage with each other and wi…
View article: The Role of Beta-1 Receptors in the Response to Myocardial Ischemia
The Role of Beta-1 Receptors in the Response to Myocardial Ischemia Open
Acute myocardial ischemia is commonly diagnosed by ST-segment deviations.These deviations, however, can show a paradoxical recovery even in the face of ongoing ischemic stress.A possible mechanism for this response may be the cardio-protec…
View article: Major drivers of healthcare system costs and cost variability for routine atrial fibrillation ablation
Major drivers of healthcare system costs and cost variability for routine atrial fibrillation ablation Open
Direct costs and other services (primarily anesthesia) drive the majority costs associated with AF ablations. There is significant variability in costs for these routine, uncomplicated AF ablation procedures. The procedure operator, and no…
View article: Improving Generalization by Learning Geometry-Dependent and Physics-Based Reconstruction of Image Sequences
Improving Generalization by Learning Geometry-Dependent and Physics-Based Reconstruction of Image Sequences Open
Deep neural networks have shown promise in image reconstruction tasks, although often on the premise of large amounts of training data. In this paper, we present a new approach to exploit the geometry and physics underlying electrocardiogr…
View article: Statistical Shape Modeling of Biventricular Anatomy with Shared Boundaries
Statistical Shape Modeling of Biventricular Anatomy with Shared Boundaries Open
Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis and the comparison of shapes and their variations. SSM applies mathematics, statis…
View article: All Roads Lead to Rome: Diverse Etiologies of Tricuspid Regurgitation Create a Predictable Constellation of Right Ventricular Shape Changes
All Roads Lead to Rome: Diverse Etiologies of Tricuspid Regurgitation Create a Predictable Constellation of Right Ventricular Shape Changes Open
Introduction: Myriad disorders cause right ventricular (RV) dilation and lead to tricuspid regurgitation (TR). Because the thin-walled, flexible RV is mechanically coupled to the pulmonary circulation and the left ventricular septum, it di…
View article: Patient‐reported outcomes and costs associated with vascular closure and same‐day discharge following atrial fibrillation ablation
Patient‐reported outcomes and costs associated with vascular closure and same‐day discharge following atrial fibrillation ablation Open
Background We aimed to measure patient‐reported outcomes (PROs) and costs associated with same‐day discharge (SDD) for atrial fibrillation (AF) ablation and vascular closure device implantation in clinical practice. Methods PROs were prosp…
View article: Reconstruction of cardiac position using body surface potentials
Reconstruction of cardiac position using body surface potentials Open
View article: Interpretable Modeling and Reduction of Unknown Errors in Mechanistic Operators
Interpretable Modeling and Reduction of Unknown Errors in Mechanistic Operators Open
View article: Statistical Shape Modeling of Biventricular Anatomy with Shared Boundaries
Statistical Shape Modeling of Biventricular Anatomy with Shared Boundaries Open
View article: Few-Shot Generation of Personalized Neural Surrogates for Cardiac Simulation via Bayesian Meta-learning
Few-Shot Generation of Personalized Neural Surrogates for Cardiac Simulation via Bayesian Meta-learning Open
View article: Body Surface Potential Mapping: Contemporary Applications and Future Perspectives
Body Surface Potential Mapping: Contemporary Applications and Future Perspectives Open
Body surface potential mapping (BSPM) is a noninvasive modality to assess cardiac bioelectric activity with a rich history of practical applications for both research and clinical investigation. BSPM provides comprehensive acquisition of b…
View article: Impact of Catheter Ablation on Stroke, Cognitive Decline and Dementia
Impact of Catheter Ablation on Stroke, Cognitive Decline and Dementia Open
AF has been consistently associated with multiple forms of dementia, including idiopathic dementia. Outcomes after catheter ablation for AF are favourable and patients experience a better quality of life, arrhythmia-free survival, and lowe…
View article: Combining endocardial mapping and electrocardiographic imaging (ECGI) for improving PVC localization: A feasibility study
Combining endocardial mapping and electrocardiographic imaging (ECGI) for improving PVC localization: A feasibility study Open