Brianna J. McIntosh
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View article: Engineered CD47 protects T cells for enhanced antitumour immunity
Engineered CD47 protects T cells for enhanced antitumour immunity Open
View article: An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma
An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma Open
The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods to engin…
View article: Engineered CD47 protects T cells for enhanced antitumor immunity
Engineered CD47 protects T cells for enhanced antitumor immunity Open
Adoptively transferred T cells and agents designed to block the CD47/SIRPα axis are promising antitumor therapeutics, which activate distinct arms of the immune system. We administered anti-CD47 (αCD47) with adoptively transferred T cells …
View article: Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning Open
View article: An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy
An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy Open
View article: Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning Open
Understanding the spatial organization of tissues is of critical importance for both basic and translational research. While recent advances in tissue imaging are opening an exciting new window into the biology of human tissues, interpreti…