Brice Kauffmann
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View article: Author Correction: Characterization of an amyloid-based antiphage defence system in Escherichia coli
Author Correction: Characterization of an amyloid-based antiphage defence system in Escherichia coli Open
View article: Intravenous Thrombolysis for Pediatric Acute Ischemic Stroke
Intravenous Thrombolysis for Pediatric Acute Ischemic Stroke Open
This cohort study examines function and safety outcomes among children with pediatric acute ischemic stroke treated with intravenous tissue plasminogen activator compared with standard care.
View article: Probing the Nonlinear Chiroptical Activity of Multiturn Aromatic Helices Using Linearly Polarized Light
Probing the Nonlinear Chiroptical Activity of Multiturn Aromatic Helices Using Linearly Polarized Light Open
Four quinoline‐based oligoamide foldamers of varying lengths, from 6 to 28 Å, were synthesized in both of their enantiomeric forms, exhibiting between 1.6 and 6 helical turns. The helically chiral structures were analyzed using hyper‐Rayle…
View article: Optimal Stapling of a Helical Peptide‐Foldamer Hybrid Using a <i>C</i>‐Terminal 4‐Mercaptoproline Enhances Protein Surface Recognition and Cellular Activity
Optimal Stapling of a Helical Peptide‐Foldamer Hybrid Using a <i>C</i>‐Terminal 4‐Mercaptoproline Enhances Protein Surface Recognition and Cellular Activity Open
Structural analysis of a co‐crystal of a helically‐folded peptide‐foldamer hybrid in complex with hDM2 E3 ubiquitin ligase, revealed a unique orientation for the C ‐terminal proline with the pyrrolidine ring pointing backwards in the seque…
View article: Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties
Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties Open
View article: Clinical Effectiveness of Newborn Screening for Spinal Muscular Atrophy: A Nonrandomized Controlled Trial
Clinical Effectiveness of Newborn Screening for Spinal Muscular Atrophy: A Nonrandomized Controlled Trial Open
(Abstracted from JAMA Pediatr 2024;178(6):540–547 Spinal muscular atrophy (SMA) is a genetic disorder characterized by progressive muscle weakness and atrophy, with the most severe cases leading to ventilator dependency or death within 2 y…
View article: Amyloid signaling in antiphage defense
Amyloid signaling in antiphage defense Open
Immune regulated cell death (RCD) is a defense strategy common to different domains of life involving purposeful sacrifice of infected cells. In animals and fungi, functional amyloids play a role in the control of RCD as molecular switches…
View article: Endovascular thrombectomy for childhood stroke (Save ChildS Pro): an international, multicentre, prospective registry study
Endovascular thrombectomy for childhood stroke (Save ChildS Pro): an international, multicentre, prospective registry study Open
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View article: A comprehensive comparative study of ultrasound-alkaline and thermal-alkaline hydrolysis of duck feather
A comprehensive comparative study of ultrasound-alkaline and thermal-alkaline hydrolysis of duck feather Open
View article: Does <i>Acinetobacter calcoaceticus</i> glucose dehydrogenase produce self-damaging H2O2?
Does <i>Acinetobacter calcoaceticus</i> glucose dehydrogenase produce self-damaging H2O2? Open
The soluble glucose dehydrogenase (sGDH) from Acinetobacter calcoaceticus has been widely studied and is used, in biosensors, to detect the presence of glucose, taking advantage of its high turnover and insensitivity to molecular oxygen. T…
View article: Digenic Leigh syndrome on the background of the m.11778G&gt;A Leber hereditary optic neuropathy variant
Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant Open
Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterized by bilateral basal ganglia and/or brainstem lesions. LSS is associated with varia…
View article: A Chiral [2+3] Covalent Organic Cage Based on 1,1’‐Bi‐2‐naphthol (BINOL) Units
A Chiral [2+3] Covalent Organic Cage Based on 1,1’‐Bi‐2‐naphthol (BINOL) Units Open
A [2+3] chiral covalent organic cage is produced through a dynamic covalent chemistry approach by mixing two readily available building units, viz. an enantiopure 3,3’‐diformyl 2,2’‐BINOL compound ( A ) with a triamino spacer ( B ). The tw…
View article: CapP mediates the structural formation of biofilm-specific pili in the opportunistic human pathogen <i>Bacillus cereus</i>
CapP mediates the structural formation of biofilm-specific pili in the opportunistic human pathogen <i>Bacillus cereus</i> Open
SUMMARY Polymeric proteinaceous filaments are structural scaffolds that diversify the functionality of the bacterial extracellular matrix. Here, we report a previously uncharacterized bacterial factor called bc1280 that is exclusive to B. …
View article: Palmitic acid at high concentration modifies the nanoscale structure of anhydrous milk fat
Palmitic acid at high concentration modifies the nanoscale structure of anhydrous milk fat Open
We performed a nanoscale study based on X-ray scattering to understand the impact of a promotor of crystallization, palmitic acid (PA), at high concentration, on the networks of triacylglycerols (TAGs) in anhydrous milk fat (AMF). Melted b…
View article: Solvent dependent hierarchical dual helicity in a fused [4]carbohelicene/quinoline oligoamide foldamer
Solvent dependent hierarchical dual helicity in a fused [4]carbohelicene/quinoline oligoamide foldamer Open
Two classes of helical motif, namely a [4]carbohelicene and an aromatic oligoamide foldamer, were fused to form a hybrid molecular construct in which their helical axes are parallel.
View article: Photon-gated foldaxane assembly/disassembly
Photon-gated foldaxane assembly/disassembly Open
An aromatic oligoamide sequence integrating multiple anthracene motifs forms a supramolecular helix-on-axle architecture exhibiting photodriven guest expulsion with thermal reversibility.
View article: Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure
Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure Open
View article: Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers
Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers Open
Invited for the cover of this issue is the group of Gilles Guichard at the University of Bordeaux. The image depicts sketches and technical drawing tools to illustrate the creation and precise characterization of foldamer tertiary structur…
View article: Design of Metal–Organic Assemblies via Shape Complementarity and Conformational Constraints in Dual Curvature Ligands
Design of Metal–Organic Assemblies via Shape Complementarity and Conformational Constraints in Dual Curvature Ligands Open
While common in biological systems, building blocks with low symmetry and flexibility pose numerous problems for synthetic self-assembly, such as the formation of isomers of assemblies that are difficult to distinguish and purify. In this …
View article: Front Cover: Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers (Chem. Eur. J. 39/2023)
Front Cover: Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers (Chem. Eur. J. 39/2023) Open
Foldamer hairpin-like motifs have been prepared by connecting oligourea helices with various alkyl and aralkyl linkers, and their structures were determined by X-ray diffraction. Some specific geometrical parameters like interhelical dihed…
View article: Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure
Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure Open
Hfq is a pleitropic actor, serving as stress response and virulence factor in the bacterial cell. It achieves this function mostly through its binding to small noncoding RNAs, conferring annealing with mRNAs. To execute these functions, Hf…
View article: CCDC 1973370: Experimental Crystal Structure Determination
CCDC 1973370: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 966605: Experimental Crystal Structure Determination
CCDC 966605: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2013479: Experimental Crystal Structure Determination
CCDC 2013479: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2013427: Experimental Crystal Structure Determination
CCDC 2013427: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 966606: Experimental Crystal Structure Determination
CCDC 966606: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2013429: Experimental Crystal Structure Determination
CCDC 2013429: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2217466: Experimental Crystal Structure Determination
CCDC 2217466: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A pH‐ and Metal‐Actuated Molecular Shuttle in Water
A pH‐ and Metal‐Actuated Molecular Shuttle in Water Open
The structure of the Viologen‐Phenylene‐Imidazole ( VPI ) guest, previously shown to be bound by cucurbit[7]uril (CB[7]) with binding modes depending on pH and silver ions, has been extended by adding hydrophobic groups on the two extremit…
View article: CCDC 2103076: Experimental Crystal Structure Determination
CCDC 2103076: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …