Bridget C. Lear
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View article: Binding profiles for 961<i>Drosophila</i>and<i>C. elegans</i>transcription factors reveal tissue-specific regulatory relationships
Binding profiles for 961<i>Drosophila</i>and<i>C. elegans</i>transcription factors reveal tissue-specific regulatory relationships Open
A catalog of transcription factor (TF) binding sites in the genome is critical for deciphering regulatory relationships. Here, we present the culmination of the efforts of the modENCODE (model organism Encyclopedia of DNA Elements) and mod…
View article: Correction to: SleepMat: a new behavioral analysis software program for sleep and circadian rhythms
Correction to: SleepMat: a new behavioral analysis software program for sleep and circadian rhythms Open
View article: Binding profiles for 954 Drosophila and<i>C. elegans</i>transcription factors reveal tissue specific regulatory relationships
Binding profiles for 954 Drosophila and<i>C. elegans</i>transcription factors reveal tissue specific regulatory relationships Open
SUMMARY A catalog of transcription factor (TF) binding sites in the genome is critical for deciphering regulatory relationships. Here we present the culmination of the modERN (model organism Encyclopedia of Regulatory Networks) consortium …
View article: SleepMat: a new behavioral analysis software program for sleep and circadian rhythms
SleepMat: a new behavioral analysis software program for sleep and circadian rhythms Open
Study Objectives To develop a new publicly available software SleepMat that analyzes Drosophila Activity Monitoring system data. Methods The software is built on Matlab platform, employs an easy-to-use graphic user interface, and is highly…
View article: PRL1 and CK2 collaborate to time morning and evening phase in short photoperiods
PRL1 and CK2 collaborate to time morning and evening phase in short photoperiods Open
The TIMELESS (TIM) phosphatase, Phosphatase of Regenerating Liver-1 (PRL-1 ), is required for setting behavioral phase especially under short photoperiod conditions. Yet the circadian clock neurons and underlying mechanisms important for t…
View article: <i>SleepMat</i>: A New Behavioral Analysis Software Program for Sleep and Circadian Rhythms
<i>SleepMat</i>: A New Behavioral Analysis Software Program for Sleep and Circadian Rhythms Open
Drosophila is a premier model for the study of circadian rhythms and sleep, revealing molecular mechanisms that are conserved with vertebrates, including humans. The Drosophila Activity Monitoring (DAM) system has been employed for automat…
View article: Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila
Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila Open
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo remain to be elucidated. To address this question, we de…
View article: The E3 ubiquitin ligase adaptor <i>Tango10</i> links the core circadian clock to neuropeptide and behavioral rhythms
The E3 ubiquitin ligase adaptor <i>Tango10</i> links the core circadian clock to neuropeptide and behavioral rhythms Open
Significance In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene, Tango10 , crit…
View article: The microtubule-associated protein Tau suppresses the axonal distribution of PDF neuropeptide and mitochondria in circadian clock neurons
The microtubule-associated protein Tau suppresses the axonal distribution of PDF neuropeptide and mitochondria in circadian clock neurons Open
Disrupted circadian rhythms are a prominent feature of multiple neurodegenerative diseases. Yet mechanisms linking Tau to rhythmic behavior remain unclear. Here, we find that expression of a phosphomimetic human Tau mutant (TauE14) in Dros…
View article: Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS
Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS Open
View article: The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity
The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity Open
The sodium leak channel NARROW ABDOMEN (NA)/ NALCN is an important component of circadian pacemaker neuronal output. In Drosophila, rhythmic expression of the NA channel regulator Nlf-1 in a subset of adult pacemaker neurons …
View article: A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability Open