Bridget E. Begg
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View article: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2
Coordination of nuclear RNA processing by speckle-localized kinase TAOK2 Open
Nuclear speckles are membraneless organelles that act as active splicing hubs especially at sites of high transcription. Emerging views of this dynamic subnuclear structure place it as a hub of RNA processing, impacting steps from transcri…
View article: Viral Modulation of Host Splicing
Viral Modulation of Host Splicing Open
The discovery of precursor messenger RNA splicing was made through the study of adenovirus in the 1970s, and since then, the role of splicing in viral infection has been an important area of study. However, most of the work in this area pr…
View article: Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response
Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response Open
Non-classically-restricted T cells have shown remarkable therapeutic activity in a variety of disease settings; most notably, CD8 T cells restricted to MHC-E (Qa-1 in mice; HLA-E in humans) have proven capable of eliminating a primate lent…
View article: Nuclear speckle integrity and function require TAO2 kinase
Nuclear speckle integrity and function require TAO2 kinase Open
Nuclear speckles are non–membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, incl…
View article: Secondary motifs enable concentration-dependent regulation by Rbfox family proteins
Secondary motifs enable concentration-dependent regulation by Rbfox family proteins Open
The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart, and muscle. Rbfox proteins have long been known to bind to the RNA sequ…
View article: A reference map of the human protein interactome
A reference map of the human protein interactome Open
Global insights into cellular organization and function require comprehensive understanding of interactome networks. Similar to how a reference genome sequence revolutionized human genetics, a reference map of the human interactome network…