Bridget Riley-Gills
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View article: Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk
Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk Open
BACKGROUND: Preeclampsia is associated with increased risk of subsequent maternal cardiovascular diseases (CVD) compared with normotensive pregnancies. We examined whether prolonging the duration between preeclampsia diagnosis and delivery…
View article: Narcolepsy as a potential risk factor for Schizophrenia
Narcolepsy as a potential risk factor for Schizophrenia Open
Narcolepsy is a severe sleep disorder with characteristics of fatigue, fragmented sleep, cataplexy and hypnagogic hallucinations. Earlier clinical studies have reported the onset of schizophrenia after narcolepsy but the causality behind n…
View article: Novel loci and biomedical consequences of iron homoeostasis variation
Novel loci and biomedical consequences of iron homoeostasis variation Open
View article: Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations Open
Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding…
View article: Genetic Susceptibility to Acute Viral Bronchiolitis
Genetic Susceptibility to Acute Viral Bronchiolitis Open
Background Acute viral bronchiolitis is a major cause of infant hospitalizations worldwide. Childhood bronchiolitis is considered a risk factor for asthma, suggesting shared genetic factors and biological pathways. Genetic risk loci may pr…
View article: Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women
Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women Open
PURPOSE Family history (FH) and pathogenic variants (PVs) are used for guiding risk surveillance in selected high-risk women but little is known about their impact for breast cancer screening on population level. In addition, polygenic ris…
View article: High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases
High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases Open
Formalin-fixed paraffin-embedded (FFPE) tissues stored in biobanks and pathology archives are a vast but underutilized source for molecular studies on different diseases. Beyond being the "gold standard" for preservation of diagnostic huma…
View article: Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)
Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry) Open
View article: The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections
The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections Open
View article: Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy
Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy Open
Importance A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood. Objective To disentangle the underlying genetic architecture of preeclampsia and preeclampsia or other maternal hyp…
View article: Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals
Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals Open
Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in n…
View article: Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study
Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study Open
BACKGROUND: Adverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized that APO are associated with younger age at f…
View article: Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata Open
View article: Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis Open
View article: Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes Open