Bridget S. Wilson
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View article: IgE occupancy and antigen valency cooperate to control FcεRI aggregation geometry and signaling efficiency
IgE occupancy and antigen valency cooperate to control FcεRI aggregation geometry and signaling efficiency Open
The crosslinking of IgE-bound FcεRI by multivalent allergens initiates mast cell and basophil signaling underlying Type 1 allergy. Yet, how allergen properties and IgE occupancy impact receptor aggregation and downstream signaling remain u…
View article: Symptom Management Experiences among Breast Cancer Survivors Undergoing Chemotherapy: Insights from a Mixed Method Approach
Symptom Management Experiences among Breast Cancer Survivors Undergoing Chemotherapy: Insights from a Mixed Method Approach Open
Background: Breast cancer, a significant global health concern, involves complex treatment regimens like chemotherapy that adversely affect patients’ physical and psychological well- being. The primary aim was to explore the Chemotherapy s…
View article: Strengthening emergency department response to chemical, biological, radiological, and nuclear disasters: A scoping review
Strengthening emergency department response to chemical, biological, radiological, and nuclear disasters: A scoping review Open
With the increasing number of CBRN incidents, strategies to strengthen EDs and limit the impact from a surge in patient presentations are paramount. An understanding of local CBRN risk to inform a top-hazards approach to CBRN preparedness,…
View article: Going beyond 2D: following membrane diffusion and topography in the IgE-Fc[epsilon]RI system using 3-dimensional tracking microscopy
Going beyond 2D: following membrane diffusion and topography in the IgE-Fc[epsilon]RI system using 3-dimensional tracking microscopy Open
The ability to follow and observe single molecules as they function in live cells would represent a major milestone for molecular-cellular biology. Here we present a tracking microscope that is able to track quantum dots in 3 dimensions an…
View article: Antigen properties shape organization of FcεRI aggregates to tune mast cell signaling
Antigen properties shape organization of FcεRI aggregates to tune mast cell signaling Open
Fc receptors containing immunoreceptor tyrosine-based activation motifs (ITAMs) are critical components of the innate immune system that bridge adaptive antibody recognition to cellular effector responses. In allergic responses, the high-a…
View article: Invasive group A streptococcal disease in Hawke’s Bay, New Zealand: epidemiology, manifestations and impact
Invasive group A streptococcal disease in Hawke’s Bay, New Zealand: epidemiology, manifestations and impact Open
Further action is required to address inequities in social determinants of skin health in Hawke's Bay. Mandatory national notification of iGAS would provide opportunity for improved surveillance of GAS-related disease, and consideration of…
View article: The Impact of Chemical, Biological, Radiological, Nuclear and Explosive Events on Emergency Departments: An Integrative Review
The Impact of Chemical, Biological, Radiological, Nuclear and Explosive Events on Emergency Departments: An Integrative Review Open
Introduction: Disasters occur globally and can impact emergency department (ED) services. Chemical, biological, radiological, and nuclear (CBRN) events have different characteristics in terms of onset and duration when compared to other di…
View article: Spatial Stochastic Model of the Pre-B Cell Receptor.
Spatial Stochastic Model of the Pre-B Cell Receptor. Open
Survival and proliferation of immature B lymphocytes requires expression and tonic signaling of the pre-B cell receptor (pre-BCR). This low level, ligand-independent signaling is likely achieved through frequent, but short-lived, homo inte…
View article: Data from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer
Data from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer Open
In ovarian cancer, metastasis is typically confined to the peritoneum. Surgical removal of the primary tumor and macroscopic secondary tumors is a common practice, but more effective strategies are needed to target microscopic spheroids pe…
View article: Data from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer
Data from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer Open
In ovarian cancer, metastasis is typically confined to the peritoneum. Surgical removal of the primary tumor and macroscopic secondary tumors is a common practice, but more effective strategies are needed to target microscopic spheroids pe…
View article: Supplementary Material; Supplementary Figures 1 and 2 and Supplementary Table 1 from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer
Supplementary Material; Supplementary Figures 1 and 2 and Supplementary Table 1 from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer Open
Further details on model assumptions, statistical analysis, and model parameters. Supplementary Figure 1: Vascular Densities in Bowel and Omentum Metastatic Sites for Individual Patients Do Not Correlate. Supplementary Figure 2: Box Plots …
View article: Supplementary Material; Supplementary Figures 1 and 2 and Supplementary Table 1 from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer
Supplementary Material; Supplementary Figures 1 and 2 and Supplementary Table 1 from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer Open
Further details on model assumptions, statistical analysis, and model parameters. Supplementary Figure 1: Vascular Densities in Bowel and Omentum Metastatic Sites for Individual Patients Do Not Correlate. Supplementary Figure 2: Box Plots …
View article: Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1 Open
Kanagy et al. combine biochemical and fluorescence microscopy methods to determine the interplay between positive and negative signaling molecules within the FcεRI signalosome. The results highlight the ability of ITAM-based signaling to r…
View article: Chemical, Biological, Radiological, or Nuclear Response in Queensland Emergency Services: A Multisite Study
Chemical, Biological, Radiological, or Nuclear Response in Queensland Emergency Services: A Multisite Study Open
A disaster overwhelms the normal operating capacity of a health service. Minimal research exists regarding Australian hospitals' capacity to respond to chemical, biological, radiological, or nuclear (CBRN) disasters. This article, and the …
View article: Spatial Stochastic Model of the Pre-B Cell Receptor
Spatial Stochastic Model of the Pre-B Cell Receptor Open
Survival and proliferation of immature B lymphocytes requires expression and tonic signaling of the pre-B cell receptor (pre-BCR). This low level, ligand-independent signaling is likely achieved through frequent, but short-lived, homo inte…
View article: Vigilance Performance Declines Faster When Monitoring for a Signal in Two Modalities Compared to One
Vigilance Performance Declines Faster When Monitoring for a Signal in Two Modalities Compared to One Open
vigilance unimodal bimodal sustained attention audiovisualVigilance is the maintenance of attention over prolonged periods, often required when attempting to detect infrequent and/or difficult to detect stimuli, such as in baggage screenin…
View article: VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group
VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group Open
Immunotherapies directed against B-cell surface markers have been a common developmental strategy to treat B-cell malignancies. The immunoglobulin heavy chain surrogate light chain (SLC), comprising the VpreB1 (CD179a) and Lamda5 (CD179b) …
View article: Independent Trafficking of Ig- /Ig- and -Heavy Chain Is Facilitated by Dissociation of the B Cell Antigen Receptor Complex
Independent Trafficking of Ig- /Ig- and -Heavy Chain Is Facilitated by Dissociation of the B Cell Antigen Receptor Complex Open
The BCR relays extracellular signals and internalizes Ag for processing and presentation. We have previously demonstrated that ligation of the BCR destabilizes Ig-α/Ig-β (Ig-αβ) from μ-H chain (μm). In this study we report that receptor de…
View article: EGFR transactivates RON to drive oncogenic crosstalk
EGFR transactivates RON to drive oncogenic crosstalk Open
SUMMARY Crosstalk between disparate membrane receptors is thought to drive oncogenic signaling and allow for therapeutic resistance. EGFR and RON are members of two unique receptor tyrosine kinase (RTK) subfamilies that engage in crosstalk…
View article: Editorial: Structure, Isotypes, Targets, and Post-translational Modifications of Immunoglobulins and Their Role in Infection, Inflammation and Autoimmunity
Editorial: Structure, Isotypes, Targets, and Post-translational Modifications of Immunoglobulins and Their Role in Infection, Inflammation and Autoimmunity Open
International audience
View article: Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes
Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes Open
Using a modified single-molecule pull-down (SiMPull) approach, the first direct detection of activation-dependent multisite phosphorylation on intact EGFR is provided. Integrating SiMPull data with rule-based modeling revealed roles for re…
View article: Selection and characterization of FcεRI phospho-ITAM specific antibodies
Selection and characterization of FcεRI phospho-ITAM specific antibodies Open
Post-translational modifications, such as the phosphorylation of tyrosines, are often the initiation step for intracellular signaling cascades. Pan-reactive antibodies against modified amino acids (e.g., anti-phosphotyrosine), which are of…
View article: Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ
Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ Open
Syk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors such as tetrameric (αβγ2) FcεRI. Syk activation is generally attributed to cis binding of its tandem SH2 domains to dual phosphotyrosines with…
View article: Leukemia-derived exosomes and cytokines pave the way for entry into the brain
Leukemia-derived exosomes and cytokines pave the way for entry into the brain Open
Infiltration of acute lymphoblastic leukemia (ALL) blasts into the CNS remains as a major clinical problem, with high risk for chemotherapy-resistant relapse and treatment-related morbidity. Despite the common inclusion of CNS prophylaxis …
View article: Molecular aspects of multivalent engagement between Syk and FcεRIγ
Molecular aspects of multivalent engagement between Syk and FcεRIγ Open
Syk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors such as the tetrameric (αβγ2) FcεRI The simplest model assumes that Syk activation occurs through cis binding of its tandem SH2 domains to dua…