Timothy O’Brien
YOU?
Author Swipe
View article: Implementation and utility of measurable residual disease (MRD) testing for multiple myeloma patients at a VA medical center
Implementation and utility of measurable residual disease (MRD) testing for multiple myeloma patients at a VA medical center Open
Measurable residual disease (MRD) testing in myeloma has been shown to be a strong prognostic marker for progression-free and overall survival. It may also be useful for making therapeutic decisions. The clonoSEQ Assay utilizes next genera…
View article: An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia
An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia Open
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as a cell therapy t…
View article: Pre‐empt medical liability claims over lost earnings
Pre‐empt medical liability claims over lost earnings Open
The evolving world of student‐athlete compensation is ushering in a host of other issues, including health‐, safety‐, and injury‐related concerns. With significant sums of money being paid to college student‐athletes, decisions regarding t…
View article: Intravenous Delivery of Mesenchymal Stromal Cells Reverses Müller Cell Endoplasmic Reticulum Stress in Diabetic Retinopathy
Intravenous Delivery of Mesenchymal Stromal Cells Reverses Müller Cell Endoplasmic Reticulum Stress in Diabetic Retinopathy Open
Background Mesenchymal stromal cells (MSCs) are being extensively studied as a disease-modifying therapy for complications of diabetes mellitus (DM) such as diabetic retinopathy (DR). However, the optimal treatment regimen remains unclear,…
View article: An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia
An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia Open
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as a cell therapy t…
View article: Rapid and Simplified Induction of Spinal Motor Neurons From Human Induced Pluripotent Stem Cells
Rapid and Simplified Induction of Spinal Motor Neurons From Human Induced Pluripotent Stem Cells Open
Human induced pluripotent stem cell (hiPSC)-derived motor neurons (MNs) provide a critical source for the study of motor neuron diseases (MNDs), which has been hindered by the lack of appropriate disease models for many years. Although man…
View article: miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia
miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia Open
Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutic approaches being investigated, no signi…
View article: Polyethyleneimine facilitates the growth and electrophysiological characterization of iPSC-derived motor neurons
Polyethyleneimine facilitates the growth and electrophysiological characterization of iPSC-derived motor neurons Open
Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (iPSC-MNs) as highly valuable models f…
View article: Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long‐QT Syndrome Type 3
Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long‐QT Syndrome Type 3 Open
Background Long‐QT syndrome is a primary cardiac ion channelopathy predisposing a patient to ventricular arrhythmia through delayed repolarization on the resting ECG. We aimed to establish a patient‐specific, human induced pluripotent stem…
View article: Mesenchymal stromal cell transplantation ameliorates fibrosis and microRNA dysregulation in skeletal muscle ischemia
Mesenchymal stromal cell transplantation ameliorates fibrosis and microRNA dysregulation in skeletal muscle ischemia Open
Peripheral arterial disease (PAD) is associated with lower-extremity muscle wasting. Hallmark features of PAD-associated skeletal muscle pathology include loss of skeletal muscle mass, reduced strength and physical performance, increased i…
View article: Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects
Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects Open
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, leading to various vascular complications. Accumulating evidence indicates that endothelial colony-forming cells (ECFCs) have attractive prospects for repairing …
View article: CD4+ chronic lymphocytic leukemia in an 86‐year‐old male veteran: A case report
CD4+ chronic lymphocytic leukemia in an 86‐year‐old male veteran: A case report Open
CD4+ chronic lymphocytic leukemia (CLL) represents an extremely rare example of phenotypic aberrancy within CLL. We present a case of an 86‐year‐old male veteran with a history of multiple comorbidities who was incidentally diagnosed with …
View article: Take proactive steps to limit risks, liability related to court‐storming incidents
Take proactive steps to limit risks, liability related to court‐storming incidents Open
Reports of court‐storming incidents after upset victories or championships tend to renew the focus on event security, safety, and injury prevention. This is especially true this year with the high‐profile incidents of fans colliding with s…
View article: Mesenchymal stromal cells from people with osteoporosis are fewer, and defective in both osteogenic and adipogenic capacity
Mesenchymal stromal cells from people with osteoporosis are fewer, and defective in both osteogenic and adipogenic capacity Open
Aim: Osteoporosis (OP) is caused by imbalanced bone remodelling homeostasis. It is highly prevalent, especially in post-menopausal women, resulting in high risk of fracture and morbidity. Mesenchymal stromal cells (MSCs) are osteoblast pro…
View article: Clinical potential of plasma-functionalized graphene oxide ultrathin sheets for bone and blood vessel regeneration: Insights from cellular and animal models
Clinical potential of plasma-functionalized graphene oxide ultrathin sheets for bone and blood vessel regeneration: Insights from cellular and animal models Open
Graphene and graphene oxide (GO), due to their unique chemical and physical properties, possess biochemical characteristics that can trigger intercellular signals promoting tissue regeneration. Clinical applications of thin GO-derived shee…
View article: miR-1, miR-133a, miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.
miR-1, miR-133a, miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia. Open
Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutics approaches being investigated, no sign…
View article: Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy
Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy Open
Background and aims Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal timing of adm…
View article: Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and Dysregulated microRNA Signature Associated with Ischaemic Skeletal Muscle Damage.
Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and Dysregulated microRNA Signature Associated with Ischaemic Skeletal Muscle Damage. Open
Peripheral arterial disease (PAD) is strongly associated with lower-extremity muscle wasting. Hallmark features of PAD associated skeletal muscle pathology include a loss of skeletal muscle mass, reduced strength and physical performance, …
View article: miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.
miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia. Open
Background . Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of peripheral arterial disease (PAD), and is associated with poor prognosis and high amputation rates. Novel therapeutic approaches are currently being…
View article: Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury
Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury Open
Background Ischemia/reperfusion injury is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mes…
View article: Polyethyleneimine facilitates the growth and electrophysiological characterization of motor neurons
Polyethyleneimine facilitates the growth and electrophysiological characterization of motor neurons Open
Background Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (MNs) as highly valuable mo…
View article: Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study
Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study Open
Background Individual responses to behavioural weight loss interventions can vary significantly, and a better understanding of the factors associated with successful treatment might help to target interventions for those who will benefit t…
View article: Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality
Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality Open
Background Extracellular vesicles (EV) are considered a cell-free alternative to mesenchymal stromal cell (MSC) therapy. Numerous reports describe the efficacy of EV in conferring immunomodulation and promoting angiogenesis, yet others rep…
View article: Generation of three induced pluripotent stem cell lines from a patient with KCNQ2 developmental and epileptic encephalopathy as a result of the pathogenic variant c.881C > T; p.Ala294Val (NUIGi059-A, NUIGi059-B, NUIGi059-C) and 3 healthy controls (NUIGi060-A, NUIGi060-B, NUIGi060-C)
Generation of three induced pluripotent stem cell lines from a patient with KCNQ2 developmental and epileptic encephalopathy as a result of the pathogenic variant c.881C > T; p.Ala294Val (NUIGi059-A, NUIGi059-B, NUIGi059-C) and 3 healthy controls (NUIGi060-A, NUIGi060-B, NUIGi060-C) Open
Developmental and epileptic encephalopathies (DEEs) are a group of severe, early-onset epilepsies which are often caused by genetic mutations in ion channels. Mutations in KCNQ2, which encodes the voltage-gated potassium channel Kv7.2, is …
View article: Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality
Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality Open
Background Extracellular vesicles (EV) are considered a cell-free alternative to mesenchymal stromal cell (MSC) therapy. Numerous reports describe the efficacy of EV in conferring immunomodulation and promoting angiogenesis, yet others rep…