Brigida Rusconi
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View article: CD1d+ Goblet Cells Expand Colon-Resident Immature, Intermediate and Differentiated iNKT Cells to Limit Colitis
CD1d+ Goblet Cells Expand Colon-Resident Immature, Intermediate and Differentiated iNKT Cells to Limit Colitis Open
View article: Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion
Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion Open
Background Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced hindlimb angiogenesis and tissue recovery. We hypot…
View article: Intergenerational protective anti-gut commensal immunoglobulin G originates in early life
Intergenerational protective anti-gut commensal immunoglobulin G originates in early life Open
Maternal immunoglobulins of the class G (IgGs) protect offspring from enteric infection, but when, where, and how these antibodies are physiologically generated and confer protection remains enigmatic. We found that circulating IgGs in adu…
View article: Gut microbiota induces weight gain and inflammation in the gut and adipose tissue independent of manipulations in diet, genetics, and immune development
Gut microbiota induces weight gain and inflammation in the gut and adipose tissue independent of manipulations in diet, genetics, and immune development Open
Obesity and the metabolic syndrome are complex disorders resulting from multiple factors including genetics, diet, activity, inflammation, and gut microbes. Animal studies have identified roles for each of these, however the contribution(s…
View article: Vancomycin-induced gut microbial dysbiosis alters enteric neuron–macrophage interactions during a critical period of postnatal development
Vancomycin-induced gut microbial dysbiosis alters enteric neuron–macrophage interactions during a critical period of postnatal development Open
Vancomycin is a broad-spectrum antibiotic widely used in cases of suspected sepsis in premature neonates. While appropriate and potentially lifesaving in this setting, early-life antibiotic exposure alters the developing microbiome and is …
View article: Changes in MMΦ Phenotype Influence Early Life Development of the Enteric Nervous System
Changes in MMΦ Phenotype Influence Early Life Development of the Enteric Nervous System Open
Vancomycin is a common medication given to premature infants. While protective, this treatment is associated with increased risk of developing disease later in life, including late-onset sepsis and necrotizing enterocolitis (NEC). Previous…
View article: Early Life Antibiotic Exposures Inhibits Postnatal Enteric Nervous System Maturation and Alters Neonatal Neuroimmune Interactions
Early Life Antibiotic Exposures Inhibits Postnatal Enteric Nervous System Maturation and Alters Neonatal Neuroimmune Interactions Open
The enteric nervous system (ENS) regulates intestinal homeostasis via interactions with smooth muscle, epithelium, and immune cells. To assess the impact of early life antibiotics on postnatal ENS development, we performed neuron specific …
View article: The microbial one-hit wonder
The microbial one-hit wonder Open
Intestinal inflammation, in the absence of infection, occurs from contributions by genetics and environment. Chen et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210324) challenge this concept by demonstrating that a dominant trans…
View article: Synchronization of mothers and offspring promotes tolerance and limits allergy
Synchronization of mothers and offspring promotes tolerance and limits allergy Open
Allergic disorders, characterized by Th2 immune responses to environmental substances, are increasingly common in children in Western societies. Multiple studies indicate that breastfeeding, early complementary introduction of food allerge…
View article: Maternal activation of the EGFR prevents translocation of gut-residing pathogenic <i>Escherichia coli</i> in a model of late-onset neonatal sepsis
Maternal activation of the EGFR prevents translocation of gut-residing pathogenic <i>Escherichia coli</i> in a model of late-onset neonatal sepsis Open
Late-onset sepsis (LOS) is a highly consequential complication of preterm birth and is defined by a positive blood culture obtained after 72 h of age. The causative bacteria can be found in patients’ intestinal tracts days before dissemina…
View article: The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months
The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months Open
View article: Single Nucleotide Polymorphism Analysis Indicates Genetic Distinction and Reduced Diversity of Swine-Associated Methicillin Resistant Staphylococcus aureus (MRSA) ST5 Isolates Compared to Clinical MRSA ST5 Isolates
Single Nucleotide Polymorphism Analysis Indicates Genetic Distinction and Reduced Diversity of Swine-Associated Methicillin Resistant Staphylococcus aureus (MRSA) ST5 Isolates Compared to Clinical MRSA ST5 Isolates Open
Livestock associated methicillin resistant S. aureus (LA-MRSA) are lineages adapted to livestock species. LA-MRSA can be transmitted to humans and public health concerns exist because livestock may be the largest MRSA reservoir outs…
View article: Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis
Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis Open
View article: Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA Open
Bile salt hydrolase (BSH) activity against the bile acid tauro-beta-muricholic acid (T-β-MCA) was recently reported to mediate host bile acid, glucose, and lipid homeostasis via the farnesoid X receptor (FXR) signaling pathway. An earlier …
View article: The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?
The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction? Open
View article: The Hidden Treasure of Neonatal Screening: Identifying New Risk Factors and Possible Mechanisms of Necrotizing Enterocolitis Through Big Data
The Hidden Treasure of Neonatal Screening: Identifying New Risk Factors and Possible Mechanisms of Necrotizing Enterocolitis Through Big Data Open
View article: CRISPR System Acquisition and Evolution of an Obligate Intracellular <i>Chlamydia</i> -Related Bacterium
CRISPR System Acquisition and Evolution of an Obligate Intracellular <i>Chlamydia</i> -Related Bacterium Open
Recently, a new Chlamydia-related organism, Protochlamydia naegleriophila KNic, was discovered within a Naegleria amoeba. To decipher the mechanisms at play in the modeling of genomes from the Protochlamydia genus, we sequenced the full ge…
View article: Whole Genome Sequencing for Genomics-Guided Investigations of Escherichia coli O157:H7 Outbreaks
Whole Genome Sequencing for Genomics-Guided Investigations of Escherichia coli O157:H7 Outbreaks Open
Multi isolate whole genome sequencing (WGS) and typing for outbreak investigations has become a reality in the post-genomics era. We applied this technology to strains from Escherichia coli O157:H7 outbreaks. These include isolates from se…
View article: Genome Sequences of Five Clinical Isolates of <i>Klebsiella pneumoniae</i>
Genome Sequences of Five Clinical Isolates of <i>Klebsiella pneumoniae</i> Open
Klebsiella pneumoniae is a nosocomial pathogen of emerging importance and displays resistance to broad-spectrum antibiotics, such as carbapenems. Here, we report the genome sequences of five clinical K. pneumoniae isolates , four of which …
View article: CRISPR system acquisition and evolution of an obligate intracellular<i>Chlamydia</i>-related bacterium
CRISPR system acquisition and evolution of an obligate intracellular<i>Chlamydia</i>-related bacterium Open
Recently, a new Chlamydia-related organism, Protochlamydia naegleriophila KNic, was discovered within a Naegleria amoeba. To decipher the mechanisms at play in the modeling of genomes from the Protochlamydia genus, we sequenced de novo the…
View article: Escherichia coli O157:H7 strains harbor at least three distinct sequence types of Shiga toxin 2a-converting phages
Escherichia coli O157:H7 strains harbor at least three distinct sequence types of Shiga toxin 2a-converting phages Open
View article: Genome Sequence of Bacillus thuringiensis Strain Btm27, an Egyptian Isolate Highly Toxic to Cotton Leafworm
Genome Sequence of Bacillus thuringiensis Strain Btm27, an Egyptian Isolate Highly Toxic to Cotton Leafworm Open
Bacillus thuringiensis is a potent microbial control agent against insect pests. Here, we present the draft genome of the Egyptian strain Btm27 that shows high toxicity toward the cotton leafworm. The genome contains three insecticidal gen…
View article: Characterization of the pathogenome and phylogenomic classification of enteropathogenic Escherichia coli of the O157:non-H7 serotypes
Characterization of the pathogenome and phylogenomic classification of enteropathogenic Escherichia coli of the O157:non-H7 serotypes Open
Escherichia coli of the O157 serogroup are comprised of a diverse collection of more than 100 O157:non-H7 serotypes that are found in the environment, animal reservoir and infected patients and some have been linked to severe outbreaks of …
View article: Trafficking of Estrella lausannensis in human macrophages
Trafficking of Estrella lausannensis in human macrophages Open
Estrella lausannensis is a new member of the Chlamydiales order. Like other Chlamydia-related bacteria, it is able to replicate in amoebae and in fish cell lines. A preliminary study investigating the pathogenic potential of Chlamydia-rela…