BACKGROUND: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive. METHODS: To dissect functional, transcriptional, and metabolic effects, hearts and isolated ventricular myocytes from mice harboring a moderate, cardiac-sp…

This study explores the sex-specific effects of B-vitamin supplementation on heart failure with reduced ejection fraction in mice subjected to pressure overload. Our study found that B-vitamins improved survival rates, cardiac function, and reduced fibrosis in female mice, with favorable lipidomic remodeling characterized by an increase in polyunsaturated triglycerides. In contrast, male mice exhibited persistent inflammation, fibrosis, and unfavorable lipidome remodeling despite the B-vitamin supplementation. The…

Abstract Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract believed to arise from an imbalance between its epithelial, immune and microbial components. It has been shown that biological differences (e.g. genetic, epigenetic, microbial, environmental) exist between patients with IBD. It is also known that there is important heterogeneity in the response to therapies that target very specific biological pathways (e.g. TNF‐alpha signaling, IL‐23R signalin…