Brigitte Piallat
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View article: Toward an Automatic Classification of the Different Stages of Sleep: Exploring Patterns of Neural Activity in the Subthalamic Nucleus
Toward an Automatic Classification of the Different Stages of Sleep: Exploring Patterns of Neural Activity in the Subthalamic Nucleus Open
Sleep disorders substantially impact quality of life, especially in patients with neurodegenerative diseases like Parkinson's disease. Recent advances in deep brain stimulation highlight the potential of closed‐loop adaptive stimulation th…
View article: Frequency-dependent deep brain stimulation of the lateral hypothalamic area modulates arousal level and core body temperature in healthy and parkinsonian monkey
Frequency-dependent deep brain stimulation of the lateral hypothalamic area modulates arousal level and core body temperature in healthy and parkinsonian monkey Open
View article: Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study
Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study Open
View article: Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization
Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization Open
Brain stimulation holds promise for treating brain disorders, but personalizing therapy remains challenging. Effective treatment requires establishing a functional link between stimulation parameters and brain response, yet traditional met…
View article: Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization
Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization Open
Brain stimulation holds promise for treating brain disorders, but personalizing therapy remains challenging. Effective treatment requires establishing a functional link between stimulation parameters and brain response, yet traditional met…
View article: Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures
Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures Open
View article: Focal cooling: An alternative treatment for drug‐resistant epilepsy in a mesial temporal lobe epilepsy primate model—A preliminary study
Focal cooling: An alternative treatment for drug‐resistant epilepsy in a mesial temporal lobe epilepsy primate model—A preliminary study Open
Objective Focal cooling is emerging as a relevant therapy for drug‐resistant epilepsy (DRE). However, we lack data on its effectiveness in controlling seizures that originate in deep‐seated areas like the hippocampus. We present a thermoel…
View article: Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys
Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys Open
Deep brain stimulation of the subthalamic nucleus (STN) has become the gold standard surgical treatment for Parkinson’s disease and is being investigated for obsessive compulsive disorders. Even if the role of the STN in the behavior is we…
View article: Subthalamic nucleus activity dynamics preceding clinical manifestations in a progressive Parkinson’s disease model
Subthalamic nucleus activity dynamics preceding clinical manifestations in a progressive Parkinson’s disease model Open
Background Parkinson’s disease (PD) diagnosis relies on motor symptoms such as akinesia, rigidity, and tremor, which manifest late in the disease course, contributing to delayed diagnosis. However, cognitive, and limbic manifestations may …
View article: Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus
Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus Open
Patients with Parkinson’s disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine nucleus, proposed as a target for deep brain stimulation to improve freezing of gait in P…
View article: Early onset of sleep/wake disturbances in a progressive macaque model of Parkinson’s disease
Early onset of sleep/wake disturbances in a progressive macaque model of Parkinson’s disease Open
View article: Early Daytime Sleepiness and Nighttime Slow-wave Sleep Disorganization in Progressive Macaque Model of Parkinson’s Disease
Early Daytime Sleepiness and Nighttime Slow-wave Sleep Disorganization in Progressive Macaque Model of Parkinson’s Disease Open
Parkinsonian patients often experience wake/sleep behavior disturbances, which can appear at an early stage of the disease in a way that is still not fully described. We aimed here at reproducing and characterizing these clinical signs in …
View article: Deep brain stimulation of the subthalamic nucleus in obsessive–compulsives disorders: long-term follow-up of an open, prospective, observational cohort
Deep brain stimulation of the subthalamic nucleus in obsessive–compulsives disorders: long-term follow-up of an open, prospective, observational cohort Open
Background Obsessive–compulsive disorder (OCD) is a major cause of disability in western country and responsible for severe impairment of quality of life. About 10% of patients present with severe OCD symptoms and require innovative treatm…
View article: Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: An experimental study
Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: An experimental study Open
View article: Implication of Anterior Nucleus of the Thalamus in Mesial Temporal Lobe Seizures
Implication of Anterior Nucleus of the Thalamus in Mesial Temporal Lobe Seizures Open
View article: Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing Open
Pain is a prevalent symptom of Parkinson’s disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo elect…
View article: Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP-induced primate model of Parkinson disease
Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP-induced primate model of Parkinson disease Open
View article: Author response: Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Author response: Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Pain is a prevalent symptom o…
View article: Algorithmic design of a noise-resistant and efficient closed-loop deep brain stimulation system: A computational approach
Algorithmic design of a noise-resistant and efficient closed-loop deep brain stimulation system: A computational approach Open
Advances in the field of closed-loop neuromodulation call for analysis and modeling approaches capable of confronting challenges related to the complex neuronal response to stimulation and the presence of strong internal and measurement no…
View article: On the Role of the Pedunculopontine Nucleus and Mesencephalic Reticular Formation in Locomotion in Nonhuman Primates
On the Role of the Pedunculopontine Nucleus and Mesencephalic Reticular Formation in Locomotion in Nonhuman Primates Open
The mesencephalic reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuclei, two neuronal structures thought to be key elements in the supraspinal control of locomotion, muscle tone, waking, and REM sleep. The role o…