Explanipedia

Elevated Homocysteine is Associated With Liver Fibrosis in Metabolic Dysfunction–Associated Steatotic Liver Disease in a Sex- and Menopause-Specific Manner Open

Mizuki Suzuki, Hwi Young Kim, Michael C. Reed, H. Frederik Nijhout, A. Eden Cruikshank , et al. · 2025

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity Open

Abhishek Guha, Ying Si, Reed Smith, Brijesh Kumar Singh, Benisa Zogu , et al. · 2025

Amyotrophic lateral sclerosis (ALS) is an age-related and fatal neurodegenerative disease characterized by progressive muscle weakness. There is marked heterogeneity in clinical presentation, progression, and pathophysiology with only mode…

Mitochondrial Health in Cardiometabolic Diseases and Aging: Clinical Applications of Therapeutic Fasting and Natural Supplements Open

Ashutosh Tripathi, Manish Verma, Madhulika Tripathi, Brijesh Kumar Singh · 2025

Mitochondria play a central role in cellular energy production, metabolic regulation, and oxidative stress management. Their dysfunction is a hallmark of cardiometabolic diseases, including obesity, diabetes, metabolic-associated steatotic…

ESRRA (estrogen related receptor, alpha) induces ribosomal protein RPLP1-mediated adaptive hepatic translation during prolonged starvation Open

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zou, Priyanka Gupta , et al. · 2025

Protein translation is an energy-intensive ribosome-driven process that is reduced during nutrient scarcity to conserve cellular resources. During prolonged starvation, cells selectively translate specific proteins to enhance their surviva…

10060: MASH drives HFpEF in a dietary mouse model of metabolic disease Open

Reddemma Sandireddy, Priyanka Gupta, Suganya Sakthivel, R Kumar, Madhulika Tripathi , et al. · 2024

10007: Targeting EIF5A hypusination to improve protein synthesis and mitochondrial function during MASH Open

Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa A. Widjaja, Shamini G. Shekeran , et al. · 2024

12220 Impaired Esrra-mediated Regulation Of Lysosomal Protein Translation And Autophagy In MASH: Restoration And MASH Reversal By Alternate Day Fasting Open

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Sung‐Hee Park, Vincent Giguère , et al. · 2024

Disclosure: M. Tripathi: None. K. Gauthier: None. R. Sandireddy: None. S. Park: None. V. Giguere: None. P.K. Chow: None. S. Ghosh: None. D.P. McDonnell: None. P.M. Yen: None. B. Singh: None. The regulation of global and specific protein sy…

6681 Age and Sex Disparity in NASH and the Potential Role of Estradiol Treatment for NASH Open

Madhulika Tripathi, Suganya Sakthivel, Ayako Suzuki, Brijesh Kumar Singh, Paul M. Yen · 2024

Disclosure: M. Tripathi: None. S. Sakthivel: None. A. Suzuki: None. B.K. Singh: None. P.M. Yen: None. Introduction: NAFLD (nonalcoholic fatty liver disease) and its more severe form, NASH (nonalcoholic steatohepatitis) are sexually dimorph…

The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity Open

Abhishek Guha, Ying Si, Reed Smith, Mohamed Kazamel, Nan Jiang , et al. · 2024

Amyotrophic lateral sclerosis (ALS) is an age-related and fatal neurodegenerative disease characterized by progressive muscle weakness. There is marked heterogeneity in clinical presentation, progression, and pathophysiology with only mode…

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting Open

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Guptta , et al. · 2024

Esrra regulation of Rplp1-mediated translation of lysosome/autolysosome proteins was downregulated during MASH. Alternate day fasting activated this novel pathway and improved MASH, suggesting that Esrra and Rplp1 may serve as therapeutic …

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Open

Anissa A. Widjaja, Wei‐Wen Lim, Siva Viswanathan, Sonia Chothani, Ben Corden , et al. · 2024

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases Open

Reddemma Sandireddy, Suganya Sakthivel, Priyanka Gupta, Jatin Behari, Madhulika Tripathi , et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an estimated global prevalence of more than 31%. Metabolic d…

Lower hepatic CBS and PEMT expression in advanced NAFLD: inferencing strategies to lower homocysteine with a mathematical model Open

Ayako Suzuki, Ricardo Henao, Michael C. Reed, H. Frederik Nijhout, Madhulika Tripathi , et al. · 2024

Aim: Hepatic homocysteine (Hcy) accumulation promotes inflammation and fibrosis in experimental nonalcoholic fatty liver disease (NAFLD), while vitamin B12 and folate reduce hepatic Hcy and protect animals from nonalcoholic steatohepatitis…

High-throughput tagging of endogenous loci for rapid characterization of protein function Open

Joonwon Kim, Alexander F. Kratz, Shiye Chen, Jenny Sheng, Hark Kyun Kim , et al. · 2024

To facilitate the interrogation of protein function at scale, we have developed high-throughput insertion of tags across the genome (HITAG). HITAG enables users to rapidly produce libraries of cells, each with a different protein of intere…

Dietary Determinants of Metabolic Syndrome: Focus on the Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open

Manish Verma, Madhulika Tripathi, Brijesh Kumar Singh · 2024

Metabolic syndrome, a cluster of conditions including increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels, significantly heightens the risk of cardiovascular disease, diabetes, obes…

From Plant to Patient: The Metabolic Benefits of Phytoestrogens Open

Manish Verma, Brijesh Kumar Singh, Madhulika Tripathi · 2024

In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, a diverse group of naturally occurring compounds found in plants. These compounds, with structural similarities to estrogen, are found i…

Estrogen receptor-related receptor (Esrra) induces ribosomal protein Rplp1-mediated adaptive hepatic translation during prolonged starvation Open

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Gupta , et al. · 2024

Protein translation is an energy-intensive ribosome-driven process that is reduced during nutrient scarcity to conserve cellular resources. During prolonged starvation, cells selectively translate specific proteins to enhance their surviva…

In Vitro Assessment of Antioxidant Capacity, Potential to Induce Autophagy/Mitophagy, and Mitochondrial Turnover of Natural Compounds for Cytotoxicity Studies Open

Madhulika Tripathi, Manish Verma, Brijesh Kumar Singh · 2023

The dynamic process of intracellular reduction-oxidation status (redox homeostasis) is influenced by various factors, with mitochondria being one of the most significant contributors. Mitochondria play a crucial role in the bioenergetic pa…

LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane Open

Shan Zhang, Yabo Guo, Gio Fidelito, David R. L. Robinson, Chao Liang , et al. · 2023

LINC00116 encodes a microprotein first identified as Mitoregulin (MTLN), where it was reported to localize to the inner membrane of mitochondria to regulate fatty acid oxidation and oxidative phosphorylation. These initial discoveri…

Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan Open

Anissa A. Widjaja, Wei‐Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden , et al. · 2023

Human ageing is associated with metabolic dysfunction, sarcopenia and frailty that taken together reduce healthspan. For age-associated diseases and lifespan, ERK, AMPK and mTORC1 represent critical pathways, across species 1–7 . Here we e…

Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency Open

Winifred W. Yau, Gao Bin Chen, Jin Zhou, Joel Celio Francisco, Nivetha Kanakaram Thimmukonda , et al. · 2023

Citrin deficiency (CD) is an inborn error of metabolism caused by loss-of-function of the mitochondrial aspartate/glutamate transporter, CITRIN, which is involved in both the urea cycle and malate–aspartate shuttle. Patients with CD develo…

Reply to: “Hyperhomocysteinemia predicts liver-related clinical outcomes in the general population” Open

Madhulika Tripathi, Brijesh Kumar Singh, Paul M. Yen · 2023

Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs Open

Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen‐Hao Yang , et al. · 2022

Circular RNAs are abundant, covalently closed transcripts that arise in cells through back-splicing and display distinct expression patterns across cells and developmental stages. While their functions are largely unknown, their intrinsic …

High-throughput tagging of endogenous loci for rapid characterization of protein function Open

Joonwon Kim, Alexander F. Kratz, Shiye Chen, Jenny Sheng, Liudeng Zhang , et al. · 2022

To facilitate the interrogation of protein function at scale, we have developed High-throughput Insertion of Tags Across the Genome (HITAG). HITAG enables users to rapidly produce libraries of cells, each with a different protein of intere…

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression Open

Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa A. Widjaja , et al. · 2022

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation Open

Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa A. Widjaja , et al. · 2022

Editorial: Novel Therapeutic Interventions Against Infectious Diseases: COVID-19 Open

Sugunadevi Sakkiah, Brijesh Kumar Singh, Keun Woo Lee, Chandrabose Selvaraj · 2022

EDITORIAL article Front. Pharmacol., 14 March 2022Sec.Experimental Pharmacology and Drug Discovery https://doi.org/10.3389/fphar.2022.852078

Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy Open

Madhulika Tripathi, Brijesh Kumar Singh, Elisa A. Liehn, Sheau Yng Lim, Keziah Tikno , et al. · 2022

Caffeine is among the most highly consumed substances worldwide, and it has been associated with decreased cardiovascular risk. Although caffeine has been shown to inhibit the proliferation of vascular smooth muscle cells (VSMCs), the mech…

Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy Open

Madhulika Tripathi, Brijesh Kumar Singh, Elisa A. Liehn, Sheau Yng Lim, Keziah Tikno , et al. · 2022

Caffeine is among the most highly consumed substances worldwide, and it has been associated with decreased cardiovascular risk. Although caffeine has been shown to inhibit the proliferation of vascular smooth muscle cells (VSMCs), the mech…

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting Open

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Gupta , et al. · 2021

Background Currently, little is known about the mechanism(s) regulating global and specific protein translation during non-alcoholic steatohepatitis (NASH). Methods We used puromycin-labelling, polysome profiling, ChIPseq and ChIP-qPCR, an…

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