Brinda Emu
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View article: The tumor microenvironment of non–small cell lung cancer impairs immune cell function in people with HIV
The tumor microenvironment of non–small cell lung cancer impairs immune cell function in people with HIV Open
Lung cancer is the leading cause of cancer mortality among people with HIV (PWH), with increased incidence and poor outcomes. This study explored whether the tumor microenvironment (TME) of HIV-associated non-small cell lung cancer (NSCLC)…
View article: Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection
Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection Open
Background Trafficking of immune cells to the central nervous system is hypothesized to facilitate HIV entry and immune-induced neuronal injury and is mediated by surface proteins such as chemokine receptors and α4 integrin. We longitudina…
View article: P-565. A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes with and without Ibalizumab in a Real-World Setting: United States (PROMISE-US) Study Design and Baseline Characteristics
P-565. A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes with and without Ibalizumab in a Real-World Setting: United States (PROMISE-US) Study Design and Baseline Characteristics Open
Background Multidrug resistance arises usually in people with HIV (PWH) with extensive prior exposure to antiretrovirals (ARVs). There is a need for further understanding of factors that impact the maintenance of virologic suppression in h…
View article: P-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers
P-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers Open
Background Elite controllers are people living with HIV (PLWH) who maintain their HIV viral load (VL) < 50 copies/mL without antiretroviral therapy (ART). Viremic controllers are persons who have HIV who are able to keep their VL < 2…
View article: 1014 Adrenergic receptors regulate T cell differentiation in viral infection and cancer
1014 Adrenergic receptors regulate T cell differentiation in viral infection and cancer Open
Background CD8+ T cells are critical components of the immune reaction against viral infections and cancer and have the potential to eliminate infected or malignant cells. However, when the antigen persists, CD8+ T ce…
View article: Spatial Analysis Reveals Impaired Immune Cell Function within the Tumor Microenvironment of HIV-associated Non-small Cell Lung Cancer
Spatial Analysis Reveals Impaired Immune Cell Function within the Tumor Microenvironment of HIV-associated Non-small Cell Lung Cancer Open
Background Among people with HIV (PWH), lung cancer is the leader cause of cancer mortality, with increased risk and poor clinical outcomes compared to people without HIV (PWOH). HIV is known to result in persistent global immune dysfuncti…
View article: Impact of Head and Neck Cancer Treatment on CD4 T Cell Decline and Recovery in People with HIV
Impact of Head and Neck Cancer Treatment on CD4 T Cell Decline and Recovery in People with HIV Open
View article: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion Open
View article: Infection with alternate frequencies of SARS-CoV-2 vaccine boosting for patients undergoing antineoplastic cancer treatments
Infection with alternate frequencies of SARS-CoV-2 vaccine boosting for patients undergoing antineoplastic cancer treatments Open
Patients undergoing antineoplastic therapies often exhibit reduced immune response to COVID-19 vaccination, necessitating assessment of alternate booster vaccination frequencies. However, data on reinfection risks to guide clinical decisio…
View article: Infection by SARS-CoV-2 with alternate frequencies of mRNA vaccine boosting for patients undergoing antineoplastic treatment for cancer
Infection by SARS-CoV-2 with alternate frequencies of mRNA vaccine boosting for patients undergoing antineoplastic treatment for cancer Open
Patients undergoing antineoplastic therapies often exhibit reduced immune response to COVID-19 vaccination, necessitating assessment of alternate boosting frequencies for these patients. However, data on reinfection risks to guide clinical…
View article: Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium
Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium Open
PURPOSE Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use o…
View article: Adrenergic receptors regulate T cell differentiation in viral infection and cancer
Adrenergic receptors regulate T cell differentiation in viral infection and cancer Open
CD8+ T cells are critical components of the immune reaction against viral infections and cancer and have the potential to eliminate infected or malignant cells. However, when the antigen persists, CD8+ T cells enter an exhausted state. Chr…
View article: Building an Infectious Disease Diversity, Equity, and Antiracism (ID2EA) Curriculum: A Single Center's Experience and Reflections
Building an Infectious Disease Diversity, Equity, and Antiracism (ID2EA) Curriculum: A Single Center's Experience and Reflections Open
In response to longstanding healthcare inequities unmasked by the Coronavirus Disease 2019 pandemic, the infectious diseases (ID) section at the Yale School of Medicine designed and implemented a pilot curriculum integrating Infectious Dis…
View article: PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection Open
View article: Human Immunodeficiency Virus Is Associated With Poor Overall Survival Among Patients With Head and Neck Cancer
Human Immunodeficiency Virus Is Associated With Poor Overall Survival Among Patients With Head and Neck Cancer Open
Background Head and neck squamous cell cancer (HNSCC) occurs at higher rates among persons with HIV (PWH). This study compares the impact of sociodemographic and clinicopathologic characteristics on outcomes among PWH-HNSCC compared with H…
View article: 437 Safety and efficacy of immune checkpoint inhibitors (ICI) in patients living with HIV (PLWH) and metastatic non-small cell lung cancer (NSCLC): a matched cohort study from the international CATCH-IT consortium
437 Safety and efficacy of immune checkpoint inhibitors (ICI) in patients living with HIV (PLWH) and metastatic non-small cell lung cancer (NSCLC): a matched cohort study from the international CATCH-IT consortium Open
Background Due to limited inclusion of PLWH in most ICI clinical trials, there is a paucity of data evaluating their safety and efficacy in this unique population, especially among PLWH and metastatic NSCLC. Methods In this retrospective, …
View article: Correlation between <scp>CD4</scp>/<scp>CD8</scp> ratio and neurocognitive performance during early <scp>HIV</scp> infection
Correlation between <span>CD4</span>/<span>CD8</span> ratio and neurocognitive performance during early <span>HIV</span> infection Open
Introduction CD4/CD8 ratio is a marker of immune activation in HIV infection and has been associated with neurocognitive performance during chronic infection, but little is known about the early phases. The aim of this study was to examine…
View article: Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH) Open
View article: Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in <scp>HIV</scp>‐infected older adults without viremia
Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in <span>HIV</span>‐infected older adults without viremia Open
Alterations in the components of the immune system occur with aging. The introduction of combination antiretroviral therapy (ART) has dramatically improved life expectancy in human immunodeficiency virus (HIV) infected individuals by suppr…
View article: Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population Open
Background We studied whether comorbid conditions affect strength and duration of immune responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccination in a US-based, adult population. Methods Sera (…
View article: Clinical Variables Correlate with Serum Neutralizing Antibody Titers after COVID-19 mRNA Vaccination in an Adult, US-based Population
Clinical Variables Correlate with Serum Neutralizing Antibody Titers after COVID-19 mRNA Vaccination in an Adult, US-based Population Open
Background We studied whether comorbid conditions impact strength and duration of immune responses after SARS-CoV-2 mRNA vaccination in a US-based, adult population. Methods Sera (pre-and-post-BNT162b2 vaccination) were tested serially up …
View article: Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis
Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis Open
Background People living with HIV (PLWH) have increased risk of developing cancers after controlling traditional risk factors and viral suppression. This study explores whether T cells can serve as a marker of risk for cancer among HIV-inf…
View article: Opening the door on entry inhibitors in HIV: Redefining the use of entry inhibitors in heavily treatment experienced and treatment‐limited individuals living with HIV
Opening the door on entry inhibitors in HIV: Redefining the use of entry inhibitors in heavily treatment experienced and treatment‐limited individuals living with HIV Open
Introduction Entry inhibitors are a relatively new class of antiretroviral therapy and are typically indicated in heavily treatment experienced individuals living with HIV. Despite this, there is no formal definition of ‘heavily treatment …
View article: Cancer Microbiology
Cancer Microbiology Open
Microbes play important roles in cancer from direct carcinogenic effects to their use in treatment. Cancers caused by microorganisms account for approximately 15% of cancers, primarily in low- and middle-income countries. Unique features o…
View article: Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors Open
View article: NASH limits anti-tumour surveillance in immunotherapy-treated HCC
NASH limits anti-tumour surveillance in immunotherapy-treated HCC Open
View article: PD-1<sup>high</sup>CXCR5<sup>–</sup>CD4<sup>+</sup> Peripheral Helper T (Tph) cells Promote Tissue-Homing Plasmablasts in COVID-19
PD-1<sup>high</sup>CXCR5<sup>–</sup>CD4<sup>+</sup> Peripheral Helper T (Tph) cells Promote Tissue-Homing Plasmablasts in COVID-19 Open
Summary A dysregulated immune response against coronavirus-2 (SARS-CoV-2) plays a critical role in the outcome of patients with coronavirus disease 2019 (COVID-19). A significant increase in circulating plasmablasts is characteristic of CO…
View article: Clinical Variables Correlate With Serum Neutralizing Antibody Titers After COVID-19 mRNA Vaccination in an Adult, US-Based Population
Clinical Variables Correlate With Serum Neutralizing Antibody Titers After COVID-19 mRNA Vaccination in an Adult, US-Based Population Open
View article: Decreased Overall Survival in HIV-associated Non–small-cell Lung Cancer
Decreased Overall Survival in HIV-associated Non–small-cell Lung Cancer Open
View article: Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy
Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy Open
Background: Neurocognitive dysfunction remains prevalent among people living with HIV (PLWH), even after viral suppression on combination antiretroviral therapy (cART). We investigated associations between neuropsychological performance (N…