Brinda K. Rana
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View article: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leverages 13 longitudinal datasets, including 3737 cognitively healthy adults (10,34…
View article: Do cognitive and neurophysiological effects of acute memantine “challenge” predict its clinical benefits in Alzheimer’s Disease?
Do cognitive and neurophysiological effects of acute memantine “challenge” predict its clinical benefits in Alzheimer’s Disease? Open
"Personalized" interventions based on patients' "biomarkers" may be valuable for treatments that benefit only subsets of patients. The NMDA antagonist, memantine, slows clinical progression of Alzheimer's disease (AD); this effect is heter…
View article: Effects of Cigarette Smoking and 3‐Day Smoking Abstinence on Translocator Protein 18 kDa Availability: A [<sup>18</sup>F]FEPPA Positron Emission Tomography Study
Effects of Cigarette Smoking and 3‐Day Smoking Abstinence on Translocator Protein 18 kDa Availability: A [<sup>18</sup>F]FEPPA Positron Emission Tomography Study Open
With the many negative health consequences of cigarette smoking, quitting is known to improve health in multiple domains. Using positron emission tomography/computed tomography (PET/CT) scanning, our group previously demonstrated that smok…
View article: Metabolome Alterations Associated with Three-Month Sitting-Time Reduction Among Sedentary Postmenopausal Latinas with Cardiometabolic Disease Risk
Metabolome Alterations Associated with Three-Month Sitting-Time Reduction Among Sedentary Postmenopausal Latinas with Cardiometabolic Disease Risk Open
Background: Incidence of cardiometabolic disease among U.S. Hispanics/Latinos is higher than in non-Hispanic Whites. Prolonged sitting duration is prevalent in older adults, and compounded with menopause, greatly increases cardiometabolic …
View article: Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women
Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women Open
Older adults sit during most hours of the day; more than 30% are considered physically inactive. The accumulation of prolonged sitting time is an exercise-independent risk factor for aging-related conditions such as cardiometabolic disease…
View article: G protein-coupled receptor (GPCR) pharmacogenomics
G protein-coupled receptor (GPCR) pharmacogenomics Open
The field of pharmacogenetics, the investigation of the influence of one or more sequence variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline that takes a genome-wide approach. Massively parallel, next…
View article: Pharmacogenomics Guided Spaceflight: the intersection between space-flown drugs and space genes
Pharmacogenomics Guided Spaceflight: the intersection between space-flown drugs and space genes Open
Ten years ago, it was predicted that the multi-omics revolution would also revolutionize space pharmacogenomics. Current barriers related to the findable, accessible, interoperable, and reproducible use of space-flown pharmaceutical data h…
View article: Meditation-induced bloodborne factors as an adjuvant treatment to COVID-19 disease
Meditation-induced bloodborne factors as an adjuvant treatment to COVID-19 disease Open
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while alternative approaches such as meditation, shown to improve immunity, have been…
View article: Time Domains of Hypoxia Responses and -Omics Insights
Time Domains of Hypoxia Responses and -Omics Insights Open
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechani…
View article: Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease
Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease Open
Background: Understanding metabolic mechanisms associated with cognitive changes preceding an Alzheimer’s disease (AD) diagnosis could advance our understanding of AD progression and inform preventive methods. Objective: We investigated th…
View article: Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers
Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers Open
The health impact of prolonged space flight on the human body is not well understood. Liquid biopsies based on cell-free DNA (cfDNA) or exosome analysis provide a noninvasive approach to monitor the dynamics of genomic, epigenomic and prot…
View article: Metabolic Profiling of Cognitive Aging in Midlife
Metabolic Profiling of Cognitive Aging in Midlife Open
Alzheimer's dementia (AD) begins many years before its clinical symptoms. Metabolic dysfunction represents a core feature of AD and cognitive impairment, but few metabolomic studies have focused on cognitive aging in midlife. Using an unta…
View article: The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight Open
What to expect after a year in space Space is the final frontier for understanding how extreme environments affect human physiology. Following twin astronauts, one of which spent a year-long mission on the International Space Station, Garr…
View article: Performance of the Self‐Report of the Effects of Alcohol Questionnaire Across Sexes and Generations
Performance of the Self‐Report of the Effects of Alcohol Questionnaire Across Sexes and Generations Open
Background Low level of responses (low LRs) to alcohol established using the Self‐Report of the Effects of Alcohol (SRE) questionnaire are genetically influenced phenotypes related to heavy drinking and alcohol problems. To date, most stud…
View article: Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors
Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors Open
Tolcapone enhanced neurocognition and engaged electroencephalogram measures relevant to cognitive processes in specific subgroups of healthy individuals. These findings support an experimental medicine model for identifying procognitive tr…
View article: Association of Sleep Quality on Memory-Related Executive Functions in Middle Age
Association of Sleep Quality on Memory-Related Executive Functions in Middle Age Open
Objectives: Sleep quality affects memory and executive function in older adults, but little is known about its effects in midlife. If it affects cognition in midlife, it may be a modifiable factor for later-life functioning. Methods: We ex…
View article: The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention
The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention Open
We recently reported that interleukin-6 (IL-6), an inflammatory marker associated with breast pathology and the development of breast cancer, decreases with diet intervention and weight loss in both insulin-sensitive and insulin-resistant …
View article: Amphetamine Enhances Gains in Auditory Discrimination Training in Adult Schizophrenia Patients
Amphetamine Enhances Gains in Auditory Discrimination Training in Adult Schizophrenia Patients Open
Targeted cognitive training (TCT) of auditory processing enhances higher-order cognition in schizophrenia patients. TCT performance gains can be detected after 1 training session. As a prelude to a potential clinical trial, we assessed a p…
View article: Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women
Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women Open
Background Optimal macronutrient distribution of weight loss diets has not been established. The distribution of energy from carbohydrate and fat has been observed to promote differential plasma lipid responses in previous weight loss stud…