Explanipedia

Anellovirus constraint from 2 to 6 months postpartum followed by betatorquevirus and gammatorquevirus dominance in serum and milk Open

Anne L. Timmerman, Antonia L. M. Schönert, Martin Deijs, Jacqueline van Rijswijk, Marit J. van Gils , et al. · 2025

Anelloviruses are ubiquitous, diverse viruses in the human virome not causing disease. In adults, the anellovirus composition (anellome) is dominated by alphatorqueviruses. However, infants seem to acquire their first anellovirus infection…

Anthropometry and Body Composition in Childhood: Follow‐Up of a Randomised, Double‐Blinded Controlled Trial With a Modified, Low‐Protein Infant Formula During Infancy Open

Jacqueline Muts, Stefanie M.P. Kouwenhoven, Nadja Antl, Marieke Abrahamse‐Berkeveld, Britt J. van Keulen , et al. · 2025

Introduction Formula feeding is associated with an increased obesity risk compared to breastfeeding, possibly due to its higher protein content. We aimed to investigate the influence of feeding a modified, low‐protein infant formula during…

Safety and Efficacy of Vaccination During Lactation: A Comprehensive Review of Vaccines for Maternal and Infant Health Utilizing a Large Language Model Citation Screening System Open

Sien J. Mulleners, Hannah G. Juncker, Jan Zuiderveld, Kirsten A. Ziesemer, Johannes B. van Goudoever , et al. · 2025

Newborns are born with an immature immune system, making them susceptible to infections early in life. Human milk provides essential nutrients and immunological factors that support infant immunity. Maternal vaccination during lactation ha…

Macronutrient concentrations in human milk beyond the first half year of lactation: a cohort study Open

Jacqueline Muts, Juliette I A Lukowski, Jos W. R. Twisk, Anne Schoonderwoerd, Johannes B. van Goudoever , et al. · 2024

Objective Human milk composition is dynamic. While extensive research has focused on its macronutrient concentrations during the first 6 months of lactation, limited research exists for extended lactation periods. This study aims to examin…

Formula protein versus human milk protein and the effects on growth in preterm born infants Open

Jacqueline Muts, Britt J. van Keulen, Johannes B. van Goudoever, Chris H.P. van den Akker · 2024

Purpose of review This review aims to evaluate the latest available evidence on the differences between human milk proteins versus infant formula proteins and its effects on growth and development in preterm infants. Recent findings High p…

A case series exploring the human milk polyclonal IgA1 response to repeated SARS-CoV-2 vaccinations by LC–MS based fab profiling Open

Bastiaan de Graaf, Albert Bondt, Danique M.H. van Rijswijck, Hannah G. Juncker, Sien J. Mulleners , et al. · 2024

Introduction Upon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens that will end up in circulation. In lactating women such antibodie…

Maternal stress is associated with higher protein-bound amino acid concentrations in human milk Open

Hannah G. Juncker, E.F.G. Naninck, Britt J. van Keulen, Jolinda E. Harinck, Lidewij Schipper , et al. · 2023

Background Maternal stress in the postpartum period affects not only the mother but also her newborn child, who is at increased risk of developing metabolic and mental disorders later in life. The mechanisms by which stress is transmitted …

The influence of a maternal vegan diet on carnitine and vitamin B2 concentrations in human milk Open

Hannah G. Juncker, Chris H.P. van den Akker, Pauline L. Meerdink, Anikó Kőrösi, Frédéric M. Vaz , et al. · 2023

Background The maternal diet greatly influences the nutritional composition of human milk. With the rise of vegan diets by lactating mothers, there are concerns about the nutritional adequacy of their milk. Two important nutrients, vitamin…

Physical activity in lactating women influences SARS-CoV-2-specific antibodies in human milk Open

Hannah G. Juncker, Maritt van Doesburg, Christianne J.M. de Groot, Dasja Pajkrt, Anikó Kőrösi , et al. · 2023

Our findings suggest that physical activity is beneficial for the levels of SARS-CoV-2-specific antibodies in human milk and serum, with the intensity of the physical activity being the most important contributor to this relationship. A hi…

Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate Open

Sanne J. M. Zilver, Christianne J.M. de Groot, Marloes Grobben, Sharon Remmelzwaal, Esmee Burgers , et al. · 2023

Comparing the SARS-CoV-2-specific antibody response in human milk after homologous and heterologous booster vaccinations Open

Sien J. Mulleners, Hannah G. Juncker, Eliza J. M. Ruhé, Anikó Kőrösi, Johannes B. van Goudoever , et al. · 2023

Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling Open

Kelly A. Dingess, Max Hoek, Danique M.H. van Rijswijck, Sem Tamara, Maurits A. den Boer , et al. · 2022

Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model Open

Ikrame Aknouch, Adithya Sridhar, Eline Freeze, Francesca Paola Giugliano, Britt J. van Keulen , et al. · 2022

Human milk is important for antimicrobial defense in infants and has well demonstrated antiviral activity. We evaluated the protective ability of human milk against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in …

Maternal Stress and Human Milk Antibodies During the COVID-19 Pandemic Open

Hannah G. Juncker, Eliza J. M. Ruhé, Anikó Kőrösi, Johannes B. van Goudoever, Marit J. van Gils , et al. · 2022

Importance SARS-CoV-2 -specific antibodies in human milk might protect the breastfed infant against COVID-19. One of the factors that may influence human milk antibodies is psychological stress, which is suggested to be increased in lactat…

Decreased Passive Immunity to Respiratory Viruses through Human Milk during the COVID-19 Pandemic Open

Marloes Grobben, Hannah G. Juncker, Karlijn van der Straten, A. H. Ayesha Lavell, Michiel Schinkel , et al. · 2022

Passive immunity derived from antibodies in human milk is important for protecting young infants against invading viruses. During the COVID-19 pandemic, circulation of common respiratory viruses was virtually absent due to preventative mea…

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children Open

Fiona A. Hagenbeek, Jenny van Dongen, René Pool, Amy C. Harms, Peter J. Roetman , et al. · 2022

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 met…

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children Open

Fiona A. Hagenbeek, Jenny van Dongen, René Pool, Amy C. Harms, Peter J. Roetman , et al. · 2022

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 met…

Early-Life Colonization by Anelloviruses in Infants Open

Joanna Kaczorowska, Aurelija Cicilionytė, Anne L. Timmerman, Martin Deijs, Maarten F. Jebbink , et al. · 2022

Anelloviruses (AVs) are found in the vast majority of the human population and are most probably part of a healthy virome. These viruses infect humans in the early stage of life, however, the characteristics of the first colonizing AVs are…

Comparing the human milk antibody response after vaccination with four COVID-19 vaccines: A prospective, longitudinal cohort study in the Netherlands Open

Hannah G. Juncker, Sien J. Mulleners, Eliza J. M. Ruhé, Esmée R. M. Coenen, Sjors Bakker , et al. · 2022

Humans have distinct repertoires of IgA1 Open

Kelly A. Dingess, Max Hoek, Danique M.H. van Rijswijck, Sem Tamara, Maurits A. den Boer , et al. · 2022

The most abundant immunoglobulin present in the human body is IgA1. It has the highest concentrations at the mucosal lining and in biofluids such as milk and is the second most abundant class of antibodies in serum. We assessed the structu…

Comparing Human Milk Antibody Response After 4 Different Vaccines for COVID-19 Open

Hannah G. Juncker, Sien J. Mulleners, Esmée R. M. Coenen, Johannes B. van Goudoever, Marit J. van Gils , et al. · 2022

This study aims to compare the antibody response in human milk after vaccination with mRNA-based and vector-based vaccines.

Proteoform Profiles Reveal That Alpha-1-Antitrypsin in Human Serum and Milk Is Derived From a Common Source Open

Shelley Jager, Dario A. T. Cramer, Max Hoek, Nadia J. Mokiem, Britt J. van Keulen , et al. · 2022

The Alpha-1-Antitrypsin (A1AT) protein is an important protease inhibitor highly abundant in human serum and other body fluids. Additional to functioning as a protease inhibitor, A1AT is an important acute phase protein. Here, we set out t…

Comparison of SARS-CoV-2-Specific Antibodies in Human Milk after mRNA-Based COVID-19 Vaccination and Infection Open

Hannah G. Juncker, Sien J. Mulleners, Marit J. van Gils, Tom P. L. Bijl, Christianne J.M. de Groot , et al. · 2021

SARS-CoV-2-specific antibodies are secreted into human milk of infected or vaccinated lactating women and might provide protection to the breastfed infant against COVID-19. Differences in antibody response after these types of exposure are…

The Effect of Pasteurization on the Antioxidant Properties of Human Milk: A Literature Review Open

Hannah G. Juncker, Eliza J. M. Ruhé, George L. Burchell, Chris H.P. van den Akker, Anikó Kőrösi , et al. · 2021

High rates of oxidative stress are common in preterm born infants and have short- and long-term consequences. The antioxidant properties of human milk limits the consequences of excessive oxidative damage. However, as the mother’s own milk…

Human Milk Antibodies Against SARS-CoV-2: A Longitudinal Follow-Up Study Open

Hannah G. Juncker, Michelle Romijn, Veerle N. Loth, Tom G. Caniels, Christianne J.M. de Groot , et al. · 2021

Background Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Coronavirus Disease 2019 (COVID-19). These antibodies may serve as protection against COVID-19 in infants. However, th…

The Levels of SARS-CoV-2 Specific Antibodies in Human Milk Following Vaccination Open

Hannah G. Juncker, Sien J. Mulleners, Marit J. van Gils, Christianne J.M. de Groot, Dasja Pajkrt , et al. · 2021

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being administered around the world; however, lactating women were excluded from SARS-CoV-2 vaccine trials. Therefore, knowledge about the effect of vacci…

Antibodies Against SARS-CoV-2 in Human Milk: Milk Conversion Rates in the Netherlands Open

Hannah G. Juncker, Michelle Romijn, Veerle N. Loth, Eliza J. M. Ruhé, Sjors Bakker , et al. · 2021

Background It has been demonstrated that human milk from mothers who have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains antibodies against the virus, which could play an important role in protecti…

Human Milk from Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity Open

Britt J. van Keulen, Michelle Romijn, Albert Bondt, Kelly A. Dingess, Eva Kontopodi , et al. · 2021

Background: Since the outbreak of coronavirus disease 2019 (COVID-19), many put their hopes in the rapid availability of effective immunizations. Human milk, containing antibodies against syndrome coronavirus 2 (SARS-CoV-2), may serve as m…

Sex-specific differences in HPA axis activity in VLBW preterm newborns Open

Britt J. van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F. Hartmann , et al. · 2021

Objective Sex-specific differences in hypothalamic–pituitary–adrenal axis activity might explain why male preterm infants are at higher risk of neonatal mortality and morbidity than their female counterparts. We examined whether male and f…

Breastmilk; a source of SARS-CoV-2 specific IgA antibodies Open

Britt J. van Keulen, Michelle Romijn, Albert Bondt, Kelly A. Dingess, Eva Kontopodi , et al. · 2020

Background Since the outbreak of COVID-19, many put their hopes in the rapid development of effective immunizations. For now patient isolation, physical distancing and good hygiene are the sole measures for prevention. Processed breast mil…

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