Britta Bauer
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View article: Long-term outcomes of patients with IgA nephropathy in the German CKD cohort
Long-term outcomes of patients with IgA nephropathy in the German CKD cohort Open
Background The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established. Methods From 2010 to 2012, 421 patients with biopsy-proven IgAN have b…
View article: Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort
Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort Open
Background Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort. Methods The GCKD study (N = 5217), a prospective coh…
View article: Interactive exploration of adverse events and multimorbidity in CKD
Interactive exploration of adverse events and multimorbidity in CKD Open
Background Persons with chronic kidney disease (CKD) are at increased risk of adverse events, early mortality and multimorbidity. A detailed overview of adverse event types and rates from a large CKD cohort under regular nephrological care…
View article: Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD
Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD Open
Introduction: Soluble urokinase plasminogen activation receptor (suPAR) is an immune-derived pathogenic factor for kidney and atherosclerotic disease. Whether the association between suPAR and cardiovascular (CV) outcomes is dependent on t…
View article: Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease
Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease Open
Objective Adipose tissue contributes to adverse outcomes in chronic kidney disease (CKD), but there is uncertainty regarding the prognostic relevance of different adiposity measures. We analyzed the associations of neck circumference (NC),…
View article: Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study
Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study Open
Background The progression of chronic kidney disease (CKD), a global public health burden, is accompanied by a declining number of functional nephrons. Estimation of remaining nephron mass may improve assessment of CKD progression. Uromodu…
View article: CCDC 2077462: Experimental Crystal Structure Determination
CCDC 2077462: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2077461: Experimental Crystal Structure Determination
CCDC 2077461: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: <b>ItaCORMs</b>: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates
<b>ItaCORMs</b>: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates Open
New powerful anti-inflammatory agents (prodrugs) were developed which act by esterase-triggered, simultaneous release of itaconate and the gasotransmitter carbon monoxide.
View article: Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease
Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease Open
Telomere length is known to be inversely associated with aging and has been proposed as a marker for aging-related diseases. Telomere attrition can be accelerated by oxidative stress and inflammation, both commonly present in patients with…
View article: Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease
Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease Open
Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for mitochondrial dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated with increased mortality and risk of cardiova…
View article: Cover Feature: Methyl Fumarate‐Derived Iron Carbonyl Complexes (FumET‐CORMs) as Powerful Anti‐inflammatory Agents (ChemMedChem 23/2017)
Cover Feature: Methyl Fumarate‐Derived Iron Carbonyl Complexes (FumET‐CORMs) as Powerful Anti‐inflammatory Agents (ChemMedChem 23/2017) Open
The Cover Feature shows the “championship” of anti-inflammatory agents for dendritic cells. The winners are FumET-CORMs which were developed by fusing a methyl fumarate and an enzyme-triggered carbon monoxide releasing molecule (ET-CORM). …
View article: BclI polymorphism of the glucocorticoid receptor and adrenal crisis in primary adrenal insufficiency
BclI polymorphism of the glucocorticoid receptor and adrenal crisis in primary adrenal insufficiency Open
Context Patients with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) are at a high risk of adrenal crisis (AC). Glucocorticoid sensitivity is at least partially genetically determined by polymorphisms of the gl…
View article: CCDC 1523680: Experimental Crystal Structure Determination
CCDC 1523680: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1523678: Experimental Crystal Structure Determination
CCDC 1523678: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1523679: Experimental Crystal Structure Determination
CCDC 1523679: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …