Britta E. Lindquist
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View article: Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans Open
Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the un…
View article: Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans Open
Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the un…
View article: Brain energy metabolism: A roadmap for future research
Brain energy metabolism: A roadmap for future research Open
Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships betwe…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Cortical electro-encephalography (EEG) served as the clinical reference for monitoring unconsciousness during general anesthesia. The existing EEG-based monitors classified general anesthesia states as underdosed, adequate, or overdosed, l…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Background: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Background: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate…
View article: Spreading depolarizations pose critical energy challenges in acute brain injury
Spreading depolarizations pose critical energy challenges in acute brain injury Open
Spreading depolarization (SD) is an electrochemical wave of neuronal depolarization mediated by extracellular K + and glutamate, interacting with voltage‐gated and ligand‐gated ion channels. SD is increasingly recognized as a major cause o…
View article: Patient‐derived <i>SLC6A1</i> variant <scp>S295L</scp> results in an epileptic phenotype similar to haploinsufficient mice
Patient‐derived <i>SLC6A1</i> variant <span>S295L</span> results in an epileptic phenotype similar to haploinsufficient mice Open
The solute carrier family 6 member 1 ( SLC6A1 ) gene encodes GAT‐1, a γ‐aminobutyric acid transporter expressed on astrocytes and inhibitory neurons. Mutations in SLC6A1 are associated with epilepsy and developmental disorders, including m…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate, or overdos…
View article: Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study
Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study Open
Introduction: Neuroworsening may be a sign of progressive brain injury and is a factor for treatment of traumatic brain injury (TBI) in intensive care settings. The implications of neuroworsening for clinical management and long-term seque…
View article: Electrobehavioral phenotype and seizure pharmacosensitivity in a novel mouse model of patient-derived <i>SLC6A1</i> S295L mutation-associated neurodevelopmental epilepsy
Electrobehavioral phenotype and seizure pharmacosensitivity in a novel mouse model of patient-derived <i>SLC6A1</i> S295L mutation-associated neurodevelopmental epilepsy Open
Solute carrier family 6 member 1 ( SLC6A1 ) gene encodes GAT-1, a GABA transporter expressed on glia and presynaptic terminals of inhibitory neurons. Mutations in SLC6A1 are associated with myoclonic atonic epilepsy, absence epilepsy, auti…
View article: Evidence that adenosine contributes to Leao’s spreading depression in vivo
Evidence that adenosine contributes to Leao’s spreading depression in vivo Open
Leao’s spreading depression of cortical activity is a propagating silencing of neuronal activity resulting from spreading depolarization (SD). We evaluated the contributions of action potential (AP) failure and adenosine A 1 receptor (A 1 …