Britta E. Rued
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View article: Impact of the RaS-RiPP tryglysin and culturing conditions on <i>ex-vivo</i> oral microbiomes.
Impact of the RaS-RiPP tryglysin and culturing conditions on <i>ex-vivo</i> oral microbiomes. Open
Natural products are ubiquitously produced by many species that we encounter during our daily lives. One genus, Streptococcus , can produce a wide array of quorum sensing linked natural products known as RaS-RiPPs (ribosomally synthesized …
View article: Negative regulation of <scp>MurZ</scp> and <scp>MurA</scp> underlies the essentiality of <scp>GpsB</scp> ‐ and <scp>StkP</scp> ‐mediated protein phosphorylation in <i>Streptococcus pneumoniae</i> <scp>D39</scp>
Negative regulation of <span>MurZ</span> and <span>MurA</span> underlies the essentiality of <span>GpsB</span> ‐ and <span>StkP</span> ‐mediated protein phosphorylation in <i>Streptococcus pneumoniae</i> <span>D39</span> Open
GpsB links peptidoglycan synthases to other proteins that determine the shape of the respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn ) and other low‐GC Gram‐positive bacteria. GpsB is also required for phosphorylation of p…
View article: The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus
The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus Open
Natural transformation is the process by which bacteria take up DNA and allows for acquisition of new genetic traits, including those involved in antibiotic resistance. This study demonstrates that the understudied species Streptococcus fe…
View article: Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in<i>Streptococcus pneumoniae</i>D39
Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in<i>Streptococcus pneumoniae</i>D39 Open
GpsB links peptidoglycan synthases to other proteins that determine the shape of the respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn ) and other low-GC Gram-positive bacteria. GpsB is also required for phosphorylation of p…
View article: The ComRS-SigX pathway regulates natural transformation in<i>Streptococcus ferus</i>
The ComRS-SigX pathway regulates natural transformation in<i>Streptococcus ferus</i> Open
The ability to take up and incorporate foreign DNA via natural transformation is a well-known characteristic of some species of Streptococcus, and is a mechanism that rapidly allows for the acquisition of antibacterial resistance. Here, we…
View article: The Proteomic and Transcriptomic Landscapes Altered by Rgg2/3 Activity in Streptococcus pyogenes
The Proteomic and Transcriptomic Landscapes Altered by Rgg2/3 Activity in Streptococcus pyogenes Open
Streptococcus pyogenes causes several important human diseases. This study evaluates how the induction or disruption of a cell-cell communication system alters S. pyogenes ’s gene expression and, in extreme conditions, its physiology.
View article: The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in <i>Streptococcus pyogenes</i>
The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in <i>Streptococcus pyogenes</i> Open
Streptococcus pyogenes , otherwise known as Group A Streptococcus (GAS), is an important and highly adaptable human pathogen with the ability to cause both superficial and severe diseases. Understanding how S. pyogenes senses and responds …
View article: Erratum for Rued et al., “Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound”
Erratum for Rued et al., “Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound” Open
Volume 12, no. 2, e02688-20, 2021, https://doi:10.1128/mBio.02688-20. The first error regards Table S1. Unfortunately, we provided an incorrect version of the table that contains incorrect references. The table has been replaced online. Se…
View article: Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound
Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound Open
Bacteria interact and compete with a large community of organisms in their natural environment. Streptococcus mutans is one such organism, and it is an important member of the oral microbiota. We found that S. mutans uses a quorum-sensing …
View article: Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae
Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae Open
FtsX is a ubiquitous bacterial integral membrane protein involved in cell division that regulates the activity of peptidoglycan (PG) hydrolases. FtsX is representative of a large group of ABC3 superfamily proteins that function as “mechano…
View article: Structure of the large extracellular loop of FtsX and its interaction with the essential peptidoglycan hydrolase PcsB in<i>Streptococcus pneumoniae</i>
Structure of the large extracellular loop of FtsX and its interaction with the essential peptidoglycan hydrolase PcsB in<i>Streptococcus pneumoniae</i> Open
Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed. Targeting bacte…
View article: The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2 Streptococcus pneumoniae D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides
The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2 Streptococcus pneumoniae D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides Open
Antimicrobial peptides (AMPs), including chemokines, are produced during infections to kill pathogenic bacteria. To fill in gaps in knowledge about the sensitivities of Streptococcus pneumoniae and related Streptococcus species to chemokin…
View article: Suppression and synthetic‐lethal genetic relationships of Δ<i>gps</i><scp><i>B</i></scp> mutations indicate that <scp>G</scp>ps<scp>B</scp> mediates protein phosphorylation and penicillin‐binding protein interactions in <scp><i>S</i></scp><i>treptococcus pneumoniae</i><scp>D</scp>39
Suppression and synthetic‐lethal genetic relationships of Δ<i>gps</i><span><i>B</i></span> mutations indicate that <span>G</span>ps<span>B</span> mediates protein phosphorylation and penicillin‐binding protein interactions in <span><i>S</i></span><i>treptococcus pneumoniae</i><span>D</span>39 Open
Summary GpsB regulatory protein and StkP protein kinase have been proposed as molecular switches that balance septal and peripheral (side‐wall like) peptidoglycan (PG) synthesis in Streptococcus pneumoniae (pneumococcus); yet, mechanisms o…
View article: Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in <i>Streptococcus pneumoniae</i>
Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in <i>Streptococcus pneumoniae</i> Open
The Fts EX :PcsB complex forms a molecular machine that carries out peptidoglycan ( PG ) hydrolysis during normal cell division of the major respiratory pathogenic bacterium, Streptococcus pneumoniae (pneumococcus). FtsX is an integral mem…
View article: Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in <scp><i>S</i></scp><i>treptococcus pneumoniae</i> D39
Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in <span><i>S</i></span><i>treptococcus pneumoniae</i> D39 Open
Summary In ellipsoid‐shaped ovococcus bacteria, such as the pathogen Streptococcus pneumoniae (pneumococcus), side‐wall (peripheral) peptidoglycan (PG) synthesis emanates from midcells and is catalyzed by the essential class B penicillin‐b…