Britta Trappmann
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Heparin flexibility within the extracellular matrix determines the bioactivity of bound vascular endothelial growth factor Open
Vascular endothelial growth factor (VEGF), a major regulator of blood vessel formation, is naturally bound to heparan sulfate proteoglycans in the extracellular matrix (ECM). Yet, how the physical presentation of VEGF by the matrix impacts…
Membrane Tension Regulation is Required for Wound Repair (Adv. Sci. 48/2024) Open
Tension‐Mediated Wound Repair Endothelial cells (yellow) that line all blood vessels of the human body can experience plasma membrane wounds, as shown by laser injury (left half). The wound is rapidly resealed by exocytosis of early endoso…
Membrane Tension Regulation is Required for Wound Repair Open
Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms invol…
Membrane tension regulation is required for wound repair Open
Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental, and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms invo…
Mechanical Strain Activates Planar Cell Polarity Signaling to Coordinate Vascular Cell Dynamics Open
SUMMARY Mechanical stimuli, particularly laminar blood flow, play a crucial role in shaping the vascular system. Changes in the rate of blood flow manifest in altered shear stress, which activates signaling cascades that drive vascular rem…
Stiffness Modulation and Pulsatile Release in Dual Responsive Hydrogels Open
Inspired by nature, self‐regulation can be introduced in synthetic hydrogels by incorporating chemo‐mechanical signals or coupled chemical reactions to maintain or adapt the material's physico‐chemical properties when exposed to external t…
Matrix Resistance Toward Proteolytic Cleavage Controls Contractility‐Dependent Migration Modes During Angiogenic Sprouting Open
Tissue homeostasis and disease states rely on the formation of new blood vessels through angiogenic sprouting, which is tightly regulated by the properties of the surrounding extracellular matrix. While physical cues, such as matrix stiffn…
View article: A Protein‐Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix‐Dependent Stiffness Responses
A Protein‐Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix‐Dependent Stiffness Responses Open
Although tissue culture plastic has been widely employed for cell culture, the rigidity of plastic is not physiologic. Softer hydrogels used to culture cells have not been widely adopted in part because coupling chemistries are required to…
A nanoporous hydrogel-based model to study chemokine gradient-driven angiogenesis under luminal flow Open
We develop a biomimetic model to uncover the synergistic effects of luminal flow and chemokine gradients on angiogenic sprouting.
Tunable Synthetic Hydrogels to Study Angiogenic Sprouting Open
Angiogenic sprouting, the formation of new blood vessels from pre‐existing vasculature, is tightly regulated by the properties of the surrounding tissue microenvironment. Although the extracellular matrix has been shown to be a major regul…
3D biomimetic environment enabling ex utero trophoblast invasion and co-culture of embryos and somatic cells Open
The first direct contact between the embryo and the mother is established during implantation. This process is inaccessible for direct studies as the implanting embryo is concealed by the maternal tissues. Here, we present a protocol for e…
Primordial germ cells adjust their protrusion type while migrating in different tissue contexts <i>in vivo</i> Open
In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their environment. As an in vivo model for this process, we use zebrafish primordial germ cells that migrate throughout the de…
Primordial germ cells adjust their protrusion type while migrating in different tissue contexts<i>in vivo</i> Open
In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their environment. As an in vivo model for this process, we use zebrafish primordial germ cells that migrate throughout the de…
Cell scientist to watch – Britta Trappmann Open
Britta Trappmann studied chemistry at the University of Dortmund, Germany. She then moved to Cambridge, UK, for her PhD (2007–2011) with Wilhelm Huck and Fiona Watt, where she discovered that stem cell fate is regulated by extracellular ma…
Blutgefäße aus dem Labor – neue Matrixeigenschaften zur Gefäßneubildung Open
Successful vascularization is a key requirement for implantable materials. In order to determine the material design criteria that are needed to support the formation of blood vessels from the surrounding host tissue, we have developed the…
Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D Open
While matrix stiffness regulates cell behavior on 2D substrates, recent studies using synthetic hydrogels have suggested that in 3D environments, cell behavior is primarily impacted by matrix degradability, independent of stiffness. Howeve…
View article: Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin
Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin Open
Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endotheli…
Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting Open
A major deficit in tissue engineering strategies is the lack of materials that promote angiogenesis, wherein endothelial cells from the host vasculature invade the implanted matrix to form new blood vessels. To determine the material prope…
Matrix degradability controls multicellularity of 3D cell migration Open
A major challenge in tissue engineering is the development of materials that can support angiogenesis, wherein endothelial cells from existing vasculature invade the surrounding matrix to form new vascular structures. To identify material …