Explanipedia

Chemotherapy efficacy in advanced melanoma patients after failure of immune checkpoint and BRAF/MEK inhibitors Open

Łukasz Galus, Daria Tusień Małecka, Michał Michalak, Sylwia Kopeć, Katarzyna Kozak , et al. · 2025

In advanced melanoma patients after failure of immune-checkpoint inhibitors with or without BRAF/MEK inhibitors, the choice of chemotherapy regimen remains dependent on the patient's general condition, comorbidities, the need for rapid red…

Clinical trial links oncolytic immunoactivation to survival in glioblastoma Open

Alexander Ling, Isaac H. Solomon, Ana Montalvo Landivar, Hiroshi Nakashima, Jared K. Woods , et al. · 2023

External Ventricular Drains versus Intraparenchymal Pressure Monitors in the Management of Moderate to Severe Traumatic Brain Injury: Experience at Two Academic Centers over a Decade Open

Rianne G. F. Dolmans, Maya Harary, Noah L. Nawabi, Trenton Taros, John L. Kilgallon , et al. · 2023

While EDH, greater midline shift, and hospital with larger patient volume were associated with receiving an IPM, the need for a craniectomy was associated with receiving an EVD. EVD patients received different clinical management than IPM …

Supratentorial cortical ependymoma: A systematic literature review and case illustration Open

Joshua A. Cuoco, Andrew Strohman, Brittany M. Stopa, Michael S. Stump, John J. Entwistle , et al. · 2022

Cortical ependymomas are currently not considered a subgroup of supratentorial ependymomas; however, there is a growing body of literature investigating the natural history of these lesions compared to supratentorial ependymomas. We perfor…

Iatrogenic Leptomeningeal Carcinomatosis Following Craniotomy for Resection of Metastatic Serous Ovarian Carcinoma: A Systematic Literature Review and Case Report Open

Brittany M. Stopa, Joshua A. Cuoco, Srijan Adhikari, Douglas J. Grider, Cara M. Rogers , et al. · 2022

Metastasis of ovarian carcinoma to the central nervous system occurs in <2% of cases and classically localizes within the brain parenchyma. Moreover, leptomeningeal spread of these tumors is an exceedingly rare phenomenon. Here, we cond…

Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors Open

Brittany M. Stopa, James Crowley, Csaba Juhász, Cara M. Rogers, Mark R. Witcher , et al. · 2022

Introduction. Positron emission tomography (PET) imaging with prostate-specific membrane antigen- (PSMA-) binding tracers has been found incidentally to demonstrate uptake in CNS tumors. Following the encouraging findings of several such c…

The low utility of routine cranial imaging after pediatric shunt revision Open

Alexander Hulsbergen, Francesca Siddi, Malia McAvoy, Benjamin T. Lynch, Madeline B. Karsten , et al. · 2021

OBJECTIVE Postoperative routine imaging is common after pediatric ventricular shunt revision, but the benefit of scanning in the absence of symptoms is questionable. In this study, the authors aimed to assess how often routine scanning res…

PATH-07. INFRATENTORIAL HIGH-GRADE GLIOMAS: NEUROSURGICAL CASE SERIES WITH MOLECULAR ANALYSIS Open

Brittany M. Stopa, Kyla Truman, Genaro R. Villa, Pierpaolo Peruzzi, William B. Gormley , et al. · 2021

INTRODUCTION Most high grade gliomas (HGG) are located supratentorially, while less than 1% arise infratentorially. Growing evidence suggests that infratentorial HGGs (iHGG) represent a collection of distinct molecular entities and that fu…

TAMI-15. PROSTATE SPECIFIC MEMBRANE ANTIGEN EXPRESSION IN GLIOBLASTOMA TUMOR AND ENDOTHELIAL CELLS Open

Brittany M. Stopa, Katherine Degen, Sharon K. Michelhaugh, Csaba Juhász, Sandeep Mittal · 2021

INTRODUCTION Prostate specific membrane antigen (PSMA) has emerged in recent years as a potential target for PET imaging of CNS tumors. Originally studied for imaging in prostate cancer, it was incidentally found to have selective uptake i…

Proceedings of the Second Regional Neurocritical Care Meeting in the Middle East and Africa in conjunction with the 17th Emirates Critical Care Conference (ECCC) Open

Ali Al Jarrah, Zabreen Tahir, Taha Yahya, Alexander Brown Whalen, Gallen Henderson , et al. · 2021

Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies Open

Brittany M. Stopa, Csaba Juhász, Sandeep Mittal · 2021

Introduction. Standard neuroimaging protocols for brain tumors have well-known limitations. The clinical use of additional modalities including amino acid PET (aaPET) and advanced MRI (aMRI) techniques (including DWI, PWI, and MRS) is emer…

Divergence in the epidemiological estimates of traumatic brain injury in the United States: comparison of two national databases Open

Brittany M. Stopa, Maya Harary, Ray Jhun, Arun Job, Saef Izzy , et al. · 2020

OBJECTIVE Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in the US, but the true incidence of TBI is unknown. METHODS The National Trauma Data Bank National Sample Program (NTDB NSP) was queried for 2007 and 201…

Decreased Incidence of CSF Leaks after Skull Base Fractures in the 21st Century: An Institutional Report Open

Brittany M. Stopa, Oscar A. Leyva, Cierra N. Harper, Kyla Truman, C. Eduardo Corrales , et al. · 2020

Objectives Cerebrospinal fluid (CSF) leaks are a possible complication in patients with skull base fractures (SBFs). The widely cited incidence of CSF leaks is 10 to 30% in SBF patients; however, this estimate is based only on a few outdat…

Preoperative functional MRI use in neurooncology patients: a clinician survey Open

Brittany M. Stopa, Joeky T. Senders, Marike L. D. Broekman, Mark Vangel, Alexandra J. Golby · 2020

OBJECTIVE Functional MRI (fMRI) is increasingly being investigated for use in neurosurgical patient care. In the current study, the authors characterize the clinical use of fMRI by surveying neurosurgeons’ use of and attitudes toward fMRI …

Traumatic brain injury as a risk factor for dementia Open

Elisabetta Mezzalira, Brittany M. Stopa, Ayaz Khawaja, Saef Izzy, William B. Gormley · 2019

Introduction The Centers for Disease Control and Prevention (CDC) reports that there were 2.87 million cases of traumatic brain injury (TBI) in the United States in 2014, 69 million worldwide. Some studies suggest a connection between TBI …

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial Open

E. Antonio Chiocca, John S. Yu, Rimas V. Lukas, Isaac H. Solomon, Keith L. Ligon , et al. · 2019

An oral small molecule turns on the transcription of human interleukin-12, with biological effects in patients with recurrent high-grade gliomas.

Comparison of minor head trauma management in the emergency departments of a United States and Italian Children’s hospital Open

Brittany M. Stopa, Stefano Amoroso, Luca Ronfani, Elena Neri, Egidio Barbi , et al. · 2019

Information-Based Medicine in Glioma Patients: A Clinical Perspective Open

Joeky T. Senders, Maya Harary, Brittany M. Stopa, Patrick Staples, Marike L. D. Broekman , et al. · 2018

Glioma constitutes the most common type of primary brain tumor with a dismal survival, often measured in terms of months or years. The thin line between treatment effectiveness and patient harm underpins the importance of tailoring clinica…

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