Brittany Rupp
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View article: Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC
Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC Open
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immun…
View article: Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: Evidence of early dissemination
Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: Evidence of early dissemination Open
Overtreatment of patients with ductal carcinoma in situ (DCIS) is driven by a lack of a reliable prognostic biomarker. Widespread mammographic screening has resulted in a substantial increase in women diagnosed with DCIS. To improve patien…
View article: Interpretable machine learning applied to high-dimensional salivary proteomics accurately classifies pediatric inflammatory bowel diseases
Interpretable machine learning applied to high-dimensional salivary proteomics accurately classifies pediatric inflammatory bowel diseases Open
Background and aims Inflammatory bowel diseases (IBD), including Crohn’s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), are chronic inflammatory disorders of the gastrointestinal tract. Current methods for classificat…
View article: Polybacterial intracellular macromolecules shape single-cell inflammatory profiles in upper airway epithelia
Polybacterial intracellular macromolecules shape single-cell inflammatory profiles in upper airway epithelia Open
Mucosal epithelial cells of the upper airways are continuously exposed to microbes throughout life. Specialized niches such as the anterior nares and the tooth are especially susceptible to dysbiosis and chronic inflammatory diseases. Here…
View article: The Single-Cell Landscape of Peripheral and Tumor-infiltrating Immune Cells in HPV- HNSCC
The Single-Cell Landscape of Peripheral and Tumor-infiltrating Immune Cells in HPV- HNSCC Open
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, which arises in the upper airway mucosa, is particularly aggressive, with nearly half of patients succumbing to the disease within…
View article: Polybacterial Intracellular Macromolecules Shape Single-Cell Epikine Profiles in Upper Airway Mucosa
Polybacterial Intracellular Macromolecules Shape Single-Cell Epikine Profiles in Upper Airway Mucosa Open
The upper airway, particularly the nasal and oral mucosal epithelium, serves as a primary barrier for microbial interactions throughout life. Specialized niches like the anterior nares and the tooth are especially susceptible to dysbiosis …
View article: CellMag‐CARWash: A High Throughput Droplet Microfluidic Device for Live Cell Isolation and Single Cell Applications
CellMag‐CARWash: A High Throughput Droplet Microfluidic Device for Live Cell Isolation and Single Cell Applications Open
The recent push toward understanding an individual cell's behavior and identifying cellular heterogeneity has created an unmet need for technologies that can probe live cells at the single‐cell level. Cells within a population are known to…
View article: Isolation and Molecular Characterization of Single Circulating Tumor and Immune Cells to Examine Heterogeneity
Isolation and Molecular Characterization of Single Circulating Tumor and Immune Cells to Examine Heterogeneity Open
Cancer patient care is limited by several factors including a lack of methods to detect cancer dissemination and progression, few treatment options, and challenges in detecting tumor heterogeneity. Circulating biomarkers can offer insights…
View article: Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer
Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer Open
As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into potentially targetable regions for cancer treatment. Circulating tumor cells (CTCs) repre…
View article: Isolation of Circulating Biomarkers for Liquid Biopsy using Immunoaffinity‐Based Stimuli‐Responsive Hybrid Hydrogel Beads
Isolation of Circulating Biomarkers for Liquid Biopsy using Immunoaffinity‐Based Stimuli‐Responsive Hybrid Hydrogel Beads Open
This work presents chemically stable and biodegradable hydrogel beads for the isolation of circulating tumor cells (CTCs) and circulating exosomes in liquid biopsy. The liquid biopsy hydrogel beads ( LB beads) consisting of alginate and po…