Bronagh Blackwood
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View article: The experiences of bedside nurses delivering an intensive care sedation study: A process evaluation within the A2B trial
The experiences of bedside nurses delivering an intensive care sedation study: A process evaluation within the A2B trial Open
Background: This process evaluation explored delivery of a complex sedation intervention within the Alpha-2 Agonists for Sedation to Produce Better Outcomes from Critical Illness (A2B) trial, which compared dexmedetomidine- and clonidine-b…
View article: An exploration of the factors influencing successful implementation, delivery and outcomes in an intensive care sedation study: process evaluation of the A2B RCT
An exploration of the factors influencing successful implementation, delivery and outcomes in an intensive care sedation study: process evaluation of the A2B RCT Open
Background Choice of sedation of critically ill patients is a core element of intensive care practice. The alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B) trial tested the effectiveness of two alpha ago…
View article: P.035 Using deferred consent in emergency research: an evaluation of two prospective CT-perfusion studies
P.035 Using deferred consent in emergency research: an evaluation of two prospective CT-perfusion studies Open
Background: Informed consent is not always possible in emergency research particularly during life threatening situations. Deferral of consent is an acceptable method in consenting patients; however, it is underutilized. We aim to share ou…
View article: B.1 Safety and effectiveness of intravenous thrombolysis for acute stroke patients in the Manitoba TeleStroke Program
B.1 Safety and effectiveness of intravenous thrombolysis for acute stroke patients in the Manitoba TeleStroke Program Open
Background: TeleStroke can improve access to stroke care in rural areas. We aim to evaluate the safety and effectiveness of intravenous thrombolysis in our TeleStroke system. Methods: The Manitoba TeleStroke program was rolled out across 7…
View article: E.5 Does administration of iodinated contrast for CT-imaging modalities impact renal function?
E.5 Does administration of iodinated contrast for CT-imaging modalities impact renal function? Open
Background: Computed tomography (CT) is common imaging modality, though its utilization of iodinated contrast media (ICM) has been historically associated with adverse effects on the kidneys including nephropathy. This study aims to invest…
View article: Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot
Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot Open
Background Usual airway clearance management in critically ill patients with acute respiratory failure includes suctioning, humidification, use of isotonic saline, and respiratory physiotherapy techniques. Escalation to use of mucoactives…
View article: Ventilator Settings in Critically Ill Pediatric Patients (VESPer)—insights from a European Registry
Ventilator Settings in Critically Ill Pediatric Patients (VESPer)—insights from a European Registry Open
Aim To explore ventilator settings, ventilation variables and parameters in critically ill pediatric patients across European Centers. Methods International, multicenter, prospective observational study, collecting ventilation data for 7 d…
View article: National screening for delirium in paediatric intensive care units: A quality improvement initiative
National screening for delirium in paediatric intensive care units: A quality improvement initiative Open
Background Internationally, one in three children develop delirium during their intensive care stay. International guidelines strongly recommend twice‐daily screening for paediatric delirium using validated instruments. In the United Kingd…
View article: Sedation and Ventilator Weaning Bundle and Time to Extubation in Infants With Bronchiolitis: Secondary Analysis of the Sedation AND Weaning in Children (SANDWICH) Trial
Sedation and Ventilator Weaning Bundle and Time to Extubation in Infants With Bronchiolitis: Secondary Analysis of the Sedation AND Weaning in Children (SANDWICH) Trial Open
OBJECTIVE: The Sedation and Weaning in Children (SANDWICH) trial of a sedation weaning and ventilator liberation bundle had a primary outcome of time to successful extubation, and showed significant but small difference. We explored the im…
View article: Patient activation and support needs in patients after ICU discharge: A UK survey of critical illness survivors
Patient activation and support needs in patients after ICU discharge: A UK survey of critical illness survivors Open
Background: Understanding the degree to which patients are actively involved, confident and capable of engaging with self-management and rehabilitation could be an initial step in guiding individualised supportive strategies for people aft…
View article: Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis Open
In comatose survivors of cardiac arrest, the majority of trials of drug therapy reported no effect on mortality. Meta-analyses of steroids, coenzyme Q10 and thiamine demonstrated no evidence of an effect on mortality. However, the low cert…
View article: 179 Physical activity and physical function in survivors of critical illness after hospital discharge: A prospective, observational study
179 Physical activity and physical function in survivors of critical illness after hospital discharge: A prospective, observational study Open
Purpose Survivors of critical illness often experience persistent physical, functional and/or cognitive impairments (i.e. Post-Intensive Care Syndrome). Currently, there is very limited rehabilitation provided as part of standard care for …
View article: PRACTICE: Development of a Core Outcome Set for Trials of Physical Rehabilitation in Critical Illness
PRACTICE: Development of a Core Outcome Set for Trials of Physical Rehabilitation in Critical Illness Open
Rationale: Findings from individual trials of physical rehabilitation interventions in critically ill adults have limited potential for meta-analysis and informing clinical decision-making because of the heterogeneity in selection a…
View article: Thirst in adult patients in the intensive care unit: A scoping review
Thirst in adult patients in the intensive care unit: A scoping review Open
Health care providers should acknowledge thirst as a prominent symptom for ICU patients. They should possess knowledge on the factors that potentially evoke or aggravate thirst. Regular and timely relief of thirst by oral care with cold sw…
View article: Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023
Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023 Open
View article: Framework for Research Gaps in Pediatric Ventilator Liberation
Framework for Research Gaps in Pediatric Ventilator Liberation Open
View article: Using patient and care partner experiences to confirm outcomes of relevance for inclusion in a core outcome set for trials of physical rehabilitation in critical illness: A qualitative interview study
Using patient and care partner experiences to confirm outcomes of relevance for inclusion in a core outcome set for trials of physical rehabilitation in critical illness: A qualitative interview study Open
COMET Initiative, ID288, https://www.comet-initiative.org/studies/details/288.
View article: A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: The <scp>BEST</scp> collaborative study
A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: The <span>BEST</span> collaborative study Open
Background Previous systematic reviews have revealed an inconsistency of outcome definitions as a major barrier in providing evidence‐based guidance for the use of plasma transfusion to prevent or treat bleeding. We reviewed and analyzed o…
View article: Communication in critical care tracheostomy patients dependent upon cuff inflation: A scoping review
Communication in critical care tracheostomy patients dependent upon cuff inflation: A scoping review Open
Open Science Framework Registries: https://osf.io/kbrjn/.
View article: Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial Open
Introduction An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonists for sedation in critical care) sedation trial is designed to de…
View article: Recovery following discharge from intensive care: What do patients think is helpful and what services are missing?
Recovery following discharge from intensive care: What do patients think is helpful and what services are missing? Open
Background Recovery following critical illness is complex due to the many challenges patients face which influence their long-term outcomes. We explored patients’ views about facilitators of recovery after critical illness which could be u…
View article: Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses
Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses Open
View article: The Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal Compared With Conventional Lung Protective Ventilation on Cardiac Function
The Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal Compared With Conventional Lung Protective Ventilation on Cardiac Function Open
OBJECTIVES: Lower tidal volume ventilation (targeting 3 mL/kg predicted body weight, PBW) facilitated by extracorporeal carbon dioxide removal (ECCO 2 R) has been investigated as a potential therapy for acute hypoxemic respiratory failure …
View article: Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK Open
Introduction Almost all patients receiving mechanical ventilation (MV) in intensive care units (ICUs) require analgesia and sedation. The most widely used sedative drug is propofol, but there is uncertainty whether alpha2-agonists are supe…
View article: Delivery of a novel intervention to facilitate liberation from mechanical ventilation in paediatric intensive care: A process evaluation
Delivery of a novel intervention to facilitate liberation from mechanical ventilation in paediatric intensive care: A process evaluation Open
Background Prolonged mechanical ventilation increases the risk of mortality and morbidity. Optimising sedation and early testing for possible liberation from invasive mechanical ventilation (IMV) has been shown to reduce time on the ventil…
View article: Correction: Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation Correction: After Resuscitation-2 (RADAR-2) randomised clinical trial
Correction: Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation Correction: After Resuscitation-2 (RADAR-2) randomised clinical trial Open
View article: Opioid, sedative, preadmission medication and iatrogenic withdrawal risk in UK adult critically ill patients: a point prevalence study
Opioid, sedative, preadmission medication and iatrogenic withdrawal risk in UK adult critically ill patients: a point prevalence study Open
View article: A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study
A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study Open
View article: Exploring the Experiences of Family Members When a Patient Is Admitted to the ICU with a Severe Traumatic Brain Injury: A Scoping Review
Exploring the Experiences of Family Members When a Patient Is Admitted to the ICU with a Severe Traumatic Brain Injury: A Scoping Review Open
The needs of family members of patients in the intensive care unit (ICU) with a severe traumatic brain injury (TBI) remain unmet. To date, no review has been performed to explore the experiences of relatives of adults who have been admitte…
View article: ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Open