Brooke L. McNeil
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View article: Synthesis and evaluation of HOPO-O8-Methyl-tetrazine as a bifunctional chelator for use in [89Zr]Zr4+, [161Tb]Tb3+ and [227Th]Th4+ radioimmunoconjugates
Synthesis and evaluation of HOPO-O8-Methyl-tetrazine as a bifunctional chelator for use in [89Zr]Zr4+, [161Tb]Tb3+ and [227Th]Th4+ radioimmunoconjugates Open
The growing availability of new radiometals with favorable decay properties for cancer diagnosis and therapy highlights the need for chelators that can stably bind a variety of metal ions. 1-Hydroxy-2(1H)-pyridinones (1,2-HOPOs) are effect…
View article: Corrigendum: Incorporation of Carboxylate Pendant Arms Into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation
Corrigendum: Incorporation of Carboxylate Pendant Arms Into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation Open
View article: Radiochemistry of cyclen-derived chelators comprising five-membered azaheterocyclic arms with 212Pb2+, 213Bi3+, and 225Ac3+
Radiochemistry of cyclen-derived chelators comprising five-membered azaheterocyclic arms with 212Pb2+, 213Bi3+, and 225Ac3+ Open
In this work, we introduce the cyclen-based metal chelator DOTThia comprising four methylthiazole arms for metal complexation. Together with the recently described congener DOTI-Me bearing four methylimidazole arms, the radiochemistry of t…
View article: Correction: Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<scp>ii</scp>)-based radiopharmaceuticals
Correction: Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<span>ii</span>)-based radiopharmaceuticals Open
Correction for ‘Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb( ii )-based radiopharmaceuticals’ by Charlene Harriswangler et al. , Inorg. Chem. Front. , 2024, 11 , 1070–1086, https://doi.org/10.1039/D3QI…
View article: Evaluating a triaza-18-crown-6 picolinate chelator for [ <sup>212/203</sup> Pb]Pb <sup>2+</sup> and [ <sup>212/213</sup> Bi]Bi <sup>3+</sup> theranostics
Evaluating a triaza-18-crown-6 picolinate chelator for [ <sup>212/203</sup> Pb]Pb <sup>2+</sup> and [ <sup>212/213</sup> Bi]Bi <sup>3+</sup> theranostics Open
Triaza-18-crown-6-based macrocycle, H 3 tripa, rapidly forms stable complexes with 203 Pb and 213 Bi; structural, thermodynamic, and computational data support H 3 tripa as a dual-purpose chelator for Pb/Bi-based radiotheranostics.
View article: Incorporation of Carboxylate Pendant Arms into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation
Incorporation of Carboxylate Pendant Arms into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation Open
We present a detailed investigation on the coordination chemistry of [ nat/203 Pb]Pb(II) with chelators H 4 PYTA and H 4 CHX ‐PYTA. These chelators belong to the family of ligands derived from the 18‐membered macrocyclic backbone PYAN and …
View article: Tuning the Softness of the Pendant Arms and the Polyazamacrocyclic Backbone to Chelate the <sup>203</sup>Pb/<sup>212</sup>Pb Theranostic Pair
Tuning the Softness of the Pendant Arms and the Polyazamacrocyclic Backbone to Chelate the <sup>203</sup>Pb/<sup>212</sup>Pb Theranostic Pair Open
A series of macrocyclic ligands were considered for the chelation of Pb2+: 1,4,7,10-tetrakis[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO4S), 1,4,7-tris[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO3…
View article: CCDC 2305214: Experimental Crystal Structure Determination
CCDC 2305214: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2305213: Experimental Crystal Structure Determination
CCDC 2305213: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<scp>ii</scp>)-based radiopharmaceuticals
Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<span>ii</span>)-based radiopharmaceuticals Open
Large 18-membered macrocycles functionalised with amide pendants show great potential for the complexation of Pb( ii ) radioisotopes, particularly when incorporating rigid cyclohexyl units into the macrocyclic scaffold.
View article: Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine
Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine Open
TRIUMF is one of the only laboratories in the world able to produce both lead-203 ( 203 Pb, t 1/2 = 51.9 h) and 212 Pb (t 1/2 = 10.6 h) onsite via its 13 and 500 MeV cyclotrons, respectively. Together, 203 Pb and 212 Pb form an element-equ…
View article: CCDC 2160768: Experimental Crystal Structure Determination
CCDC 2160768: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160767: Experimental Crystal Structure Determination
CCDC 2160767: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160769: Experimental Crystal Structure Determination
CCDC 2160769: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160772: Experimental Crystal Structure Determination
CCDC 2160772: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160770: Experimental Crystal Structure Determination
CCDC 2160770: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160771: Experimental Crystal Structure Determination
CCDC 2160771: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Evaluation of the Effect of Macrocyclic Ring Size on [<sup>203</sup>Pb]Pb(II) Complex Stability in Pyridyl-Containing Chelators
Evaluation of the Effect of Macrocyclic Ring Size on [<sup>203</sup>Pb]Pb(II) Complex Stability in Pyridyl-Containing Chelators Open
As an element-equivalent theranostic pair, lead-203 (203Pb, 100% EC, half-life = 51.92 h) and lead-212 (212Pb, 100% β-, half-life = 10.64 h), through the emission of γ rays and an α particle in its decay ch…
View article: CCDC 2154544: Experimental Crystal Structure Determination
CCDC 2154544: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging
Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging Open
Background Combining optical (fluorescence) imaging with nuclear imaging has the potential to offer a powerful tool in personal health care, where nuclear imaging offers in vivo functional whole-body visualization, and the fluorescence mod…
View article: Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging
Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging Open
Background Combining optical (fluorescence) imaging with nuclear imaging has the potential to offer a powerful tool in personal health care, where nuclear imaging offers in vivo functional whole-body visualization, and the fluorescence mod…
View article: CCDC 2080228: Experimental Crystal Structure Determination
CCDC 2080228: Experimental Crystal Structure Determination Open
View article: Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair
Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair Open
View article: Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide
Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide Open
View article: Production, Purification, and Radiolabeling of the 203Pb/212Pb Theranostic Pair
Production, Purification, and Radiolabeling of the 203Pb/212Pb Theranostic Pair Open
Background: Lead-212 ( 212 Pb, t 1/2 = 10.6 h) and lead-203 ( 203 Pb, t 1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) an…
View article: Synthesis of DOTA-Pyridine Chelates for 64Cu Coordination and Radiolabeling of αMSH Peptide
Synthesis of DOTA-Pyridine Chelates for 64Cu Coordination and Radiolabeling of αMSH Peptide Open
Background : 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of…
View article: Ligand specificity and affinity in the sulforhodamine B binding RNA aptamer
Ligand specificity and affinity in the sulforhodamine B binding RNA aptamer Open