Brooks I. Mitchell
YOU?
Author Swipe
View article: P-372. <i>Candida auris</i> Outbreak in a Cardiothoracic Transplant Intensive Care Unit: Implications for Infection Prevention
P-372. <i>Candida auris</i> Outbreak in a Cardiothoracic Transplant Intensive Care Unit: Implications for Infection Prevention Open
Background Candida auris is a yeast that causes invasive infections such as bloodstream infections (BSIs); mortality rates for C. auris BSIs may be as high as 80%. Rates have been climbing in the U.S. Exposure to skilled nursing facilities…
View article: Alterations in Renin–Angiotensin System (RAS) Peptide Levels in Patients with HIV
Alterations in Renin–Angiotensin System (RAS) Peptide Levels in Patients with HIV Open
Chronic HIV infection has long been associated with an increased risk for cardiovascular diseases. The metabolites of the renin–angiotensin system (RAS) such as angiotensin II (AngII) play an important role in regulating blood pressure and…
View article: Correction: Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation
Correction: Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation Open
[This corrects the article DOI: 10.1371/journal.pone.0231761.].
View article: Hiding in plain sight – platelets, the silent carriers of HIV-1
Hiding in plain sight – platelets, the silent carriers of HIV-1 Open
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with …
View article: Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy
Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy Open
Despite long term antiretroviral therapy (ART), insulin resistance (IR) is common among people living with HIV/AIDS (PLWHA) exposing this population to a greater risk of cardiometabolic complications when compared to their uninfected count…
View article: STEAM Learning in Public Libraries: A “Guide on the Side” Approach for Inclusive Learning
STEAM Learning in Public Libraries: A “Guide on the Side” Approach for Inclusive Learning Open
Children and their families are practicing STEAM (Science, Technology, Engineering, Arts, and Math) skills through a library program. Hand-crank generators and LED bulbs are set out on each of the tables, along with two types of dough—cond…
View article: Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes
Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes Open
Maximum carotid plaque thickness (MCPT) measures the largest plaque thickness in the carotid artery and reflects atherosclerosis plaque burden. MCPT may be a better predictor of cardiovascular disease than carotid artery intima-media thick…
View article: Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation
Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation Open
[This corrects the article DOI: 10.1371/journal.pone.0231761.].
View article: Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection
Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection Open
HIV+ individuals demonstrated opposing associations with cannabis. Recent use may weaken RSFC and prolonged consumption may exacerbate atrophy of the accumbens and other brain regions. More frequent or recent cannabis use may reduce the in…
View article: PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults
PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults Open
To the Editors: With the advent of antiretroviral therapy (ART), AIDS-related morbidity and mortality has declined allowing age-related diseases, such as cardiovascular disease (CVD), to emerge as new challenges for this population. With a…
View article: Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling
Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling Open
Endogenous plasma levels of the immunomodulatory carbohydrate-binding protein galectin-9 (Gal-9) are elevated during HIV infection and remain elevated after antiretroviral therapy (ART) suppression. We recently reported that Gal-9 regulate…
View article: ONLINE LEARNING THROUGH THE STAR LIBRARY NETWORK: RESOURCES, NETWORKING, AND APPLIED PRACTICE IN STEM PROGRAM FACILITATION
ONLINE LEARNING THROUGH THE STAR LIBRARY NETWORK: RESOURCES, NETWORKING, AND APPLIED PRACTICE IN STEM PROGRAM FACILITATION Open
The STAR Library Network (STAR Net) utilizes webinars as a key tool in its suite of professional learning opportunities relating to STEM learning in libraries. Traditionally, continuing education for library staff has taken place in person…
View article: Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection
Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection Open
Plasminogen activator inhibitor type 1 (PAI-1), a key negative regulator of fibrinolysis, has been investigated to be one of the potential mechanisms of the development of impaired insulin sensitivity, insulin resistance, and diabetes mell…
View article: Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy
Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy Open
Alterations in monocyte subpopulations and urine pro-fibrotic factors may play a role in kidney dysfunction during chronic HIV infection and warrants further study.
View article: Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy
Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy Open
Our findings highlight the role of non-classical monocytes and MCP-1 in the progression of CIMTBIF in HIV-infected individuals on stable ART independent of traditional cardio-metabolic risk factors.
View article: Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy
Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy Open
The percentage of non-classical monocytes and plasma MCP-1 levels were independently associated with CAC progression and may be related to the progression of atherosclerosis and increased CVD risk associated with chronic HIV infection on s…
View article: TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection Open
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replicati…