Bruce A. Corliss
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View article: MAD-FC: A fold change visualization with readability, proportionality, and symmetry
MAD-FC: A fold change visualization with readability, proportionality, and symmetry Open
We propose a fold change transform that demonstrates a combination of visualization properties exhibited by log and linear plots of fold change. A fold change visualization should ideally exhibit: (1) readability, where fold change values …
View article: Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1 Open
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environment…
View article: MAD-FC: A Fold Change Visualization with Readability, Proportionality, and Symmetry
MAD-FC: A Fold Change Visualization with Readability, Proportionality, and Symmetry Open
We propose a fold change visualization that demonstrates a combination of properties from log and linear plots of fold change. A useful fold change visualization can exhibit: (1) readability, where fold change values are recoverable from d…
View article: Contra-Analysis for Determining Negligible Effect Size in Scientific Research
Contra-Analysis for Determining Negligible Effect Size in Scientific Research Open
Scientific experiments study interventions that show evidence of an effect size that is meaningfully large, negligibly small, or inconclusively broad. Previously, we proposed contra-analysis as a decision-making process to help determine w…
View article: Contra-Analysis: Prioritizing Meaningful Effect Size in Scientific Research
Contra-Analysis: Prioritizing Meaningful Effect Size in Scientific Research Open
At every phase of scientific research, scientists must decide how to allocate limited resources to pursue the research inquiries with the greatest potential. This prioritization dictates which controlled interventions are studied, awarded …
View article: Polarized localization of phosphatidylserine in endothelium regulates Kir2.1
Polarized localization of phosphatidylserine in endothelium regulates Kir2.1 Open
In the resistance artery endothelium, we show phosphatidylserine (PS) localizes to a specific subpopulation of myoendothelial junctions (MEJs), signaling microdomains that regulate vasodilation. In silico data has implied PS may compete wi…
View article: The Least Difference in Means: A Statistic for Effect Size Strength and Practical Significance
The Least Difference in Means: A Statistic for Effect Size Strength and Practical Significance Open
With limited resources, scientific inquiries must be prioritized for further study, funding, and translation based on their practical significance: whether the effect size is large enough to be meaningful in the real world. Doing so must e…
View article: The Most Difference in Means: A Statistic for the Strength of Null and Near-Zero Results
The Most Difference in Means: A Statistic for the Strength of Null and Near-Zero Results Open
Statistical insignificance does not suggest the absence of effect, yet scientists must often use null results as evidence of negligible (near-zero) effect size to falsify scientific hypotheses. Doing so must assess a result's null strength…
View article: The Most Difference in Means: A Statistic for the Strength of Null and Near-Zero Results
The Most Difference in Means: A Statistic for the Strength of Null and Near-Zero Results Open
View article: Contra-Analysis: Prioritizing Meaningful Effect Size in Scientific Research
Contra-Analysis: Prioritizing Meaningful Effect Size in Scientific Research Open
View article: Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice Open
View article: Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling Open
Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their wide-ranging roles in physiology include the clearance of cellular debris, elimination of excess synapses, reg…
View article: Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis
Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis Open
View article: Oxygen-Sensing Biomaterial Construct for Clinical Monitoring of Wound Healing
Oxygen-Sensing Biomaterial Construct for Clinical Monitoring of Wound Healing Open
OBJECTIVE Oxygen is essential to wound healing; therefore, accurate monitoring can guide clinical decisions. Clinical wound assessment is often subjective, and tools to monitor wound oxygen are typically expensive, indirect, and highly var…
View article: Pericyte Bridges in Homeostasis and Hyperglycemia
Pericyte Bridges in Homeostasis and Hyperglycemia Open
Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvascu…
View article: Pericyte Bridges in Homeostasis and Hyperglycemia
Pericyte Bridges in Homeostasis and Hyperglycemia Open
Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvascu…
View article: Pericyte Bridges in Homeostasis and Hyperglycemia
Pericyte Bridges in Homeostasis and Hyperglycemia Open
Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvascu…
View article: Pericyte Bridges in Homeostasis and Hyperglycemia
Pericyte Bridges in Homeostasis and Hyperglycemia Open
Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal mic…
View article: REAVER: A program for improved analysis of high‐resolution vascular network images
REAVER: A program for improved analysis of high‐resolution vascular network images Open
Alterations in vascular networks, including angiogenesis and capillary regression, play key roles in disease, wound healing, and development. The spatial structures of blood vessels can be captured through imaging, but effective characteri…
View article: Myh11 Lineage Corneal Endothelial Cells and ASCs Populate Corneal Endothelium
Myh11 Lineage Corneal Endothelial Cells and ASCs Populate Corneal Endothelium Open
Dystrophy and dysfunction of the corneal endothelium accounts for almost half of all corneal transplants, the maintenance of the cornea endothelium is poorly understood, and there are a lack of mouse models to study specific CEC population…
View article: Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver
Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver Open
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying prot…
View article: Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver
Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver Open
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hem…
View article: REAVER: Improved Analysis of High-resolution Vascular Network Images Revealed Through Round-robin Rankings of Accuracy and Precision
REAVER: Improved Analysis of High-resolution Vascular Network Images Revealed Through Round-robin Rankings of Accuracy and Precision Open
Alterations in vascular networks, including angiogenesis and capillary regression, play key roles in disease, wound healing, and development. Imaging of microvascular networks can reveal their spatial structures, but effective study of net…
View article: REAVER Vascular Networks Fluorescent Image Dataset
REAVER Vascular Networks Fluorescent Image Dataset Open
Fluorescent Images of Vessel Networks from Various Murine Tissues Purpose: Image dataset of vascular networks with a diverse range of vessel architectures. Dataset is used to evaluate performance of severa…
View article: REAVER Vascular Networks Fluorescent Image Dataset
REAVER Vascular Networks Fluorescent Image Dataset Open
Fluorescent Images of Vessel Networks from Various Murine Tissues Purpose: Image dataset of vascular networks with a diverse range of vessel architectures. Dataset is used to evaluate performance of severa…
View article: Pericyte Bridges in Homeostasis and Hyperglycemia: Reconsidering Pericyte Dropout and Microvascular Structures
Pericyte Bridges in Homeostasis and Hyperglycemia: Reconsidering Pericyte Dropout and Microvascular Structures Open
Diabetic retinopathy threatens the vision of a third of diabetic patients. Progression of the disease is attributed to the dropout of pericytes, a cell type that enwraps and stabilizes the microvasculature. In tandem with this presumptive …
View article: Cover Image
Cover Image Open
Cover Artwork: The cover image is based on the Invited Review Methods to Label, Image, and Analyze the Complex Structural Architectures of Microvascular Networks by Bruce Corliss et al., https://doi.org/10.1111/micc.12520.
View article: Methods to label, image, and analyze the complex structural architectures of microvascular networks
Methods to label, image, and analyze the complex structural architectures of microvascular networks Open
Microvascular networks play key roles in oxygen transport and nutrient delivery to meet the varied and dynamic metabolic needs of different tissues throughout the body, and their spatial architectures of interconnected blood vessel segment…
View article: CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures
CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures Open
View article: CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures
CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures Open
Motivation Colocalization of structures in biomedical images can lead to insights into biological behaviors. One class of colocalization problems is examining an annular structure (disk-shaped such as a cell, vesicle or molecule) interacti…