Bruce Alberts
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View article: Improved production and quality of lentiviral vectors by major-splice-donor mutation and co-expression of a novel U1 snRNA-based enhancer
Improved production and quality of lentiviral vectors by major-splice-donor mutation and co-expression of a novel U1 snRNA-based enhancer Open
The clinical success in using HIV-1 based Lentiviral vectors (LVs) to deliver therapeutic genes is built upon the safety features of 3rd generation LVs. However, the Cell and Gene Therapy industry as well as regulatory agencies are continu…
View article: Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vector
Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vector Open
Chimeric antigen receptor (CAR) T cell therapy has proved remarkably successful for the treatment of hematological malignancies. However, the bespoke manufacturing of autologous CAR T cells is complex and expensive. The development of meth…
View article: Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse
Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse Open
Science is often portrayed as the objective search for knowledge. However, science is also part of complex societies that shape science and in turn are shaped by scientific findings. In this interview, Bruce Alberts, former president of th…
View article: Enhancing titers of therapeutic lentiviral vectors using PKC agonists
Enhancing titers of therapeutic lentiviral vectors using PKC agonists Open
Lentiviral vector (LV)-based therapies employ the molecular machinery of HIV-1 to stably integrate therapeutic genes into patient cells for long-term disease correction. However, suboptimal expression of LV components in HEK293T-based prod…
View article: Teaching trust in science: a critical new focus for science education
Teaching trust in science: a critical new focus for science education Open
The recent pandemic has revealed the importance of understanding how scientific knowledge is produced, if citizens are to make decisions that protect themselves, their communities, and their nations. Creating such an understanding presents…
View article: Discovery and significance of protein-protein interactions in health and disease
Discovery and significance of protein-protein interactions in health and disease Open
The identification of individual protein-protein interactions (PPIs) began more than 40 years ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new technologies emerged, analysis of PPIs increased to a geno…
View article: Progress and promise for science in Indonesia
Progress and promise for science in Indonesia Open
Is there a formula for a competitive NIH grant application? The Serenity Prayer may provide one: "Grant me the serenity to accept the things I cannot change, the ability to change the things I can, and the wisdom to know the difference." B…
View article: Scientists and journals must work together to protect the integrity of the scientific literature
Scientists and journals must work together to protect the integrity of the scientific literature Open
The scientific literature has for some years reflected serious concerns over the irreproducibility of many published scientific results; yet the problem persists. We review here how the prevailing culture contributes to this problem and su…
View article: Proteolytic regulation of calcium channels - avoiding controversy.
Proteolytic regulation of calcium channels - avoiding controversy. Open
The publication of papers containing data obtained with suboptimal rigor in the experimental design and choice of key reagents, such as antibodies, can result in a lack of reproducibility and generate controversy that can both needlessly d…
View article: Why science education is more important than most scientists think
Why science education is more important than most scientists think Open
The COVID-19 pandemic has revealed that a shockingly large fraction of the public is willing to ignore scientific judgements on issues such a vaccines and mask wearing. For far too many, scientific findings are viewed as what scientists be…
View article: Improving support for young biomedical scientists
Improving support for young biomedical scientists Open
A vibrant American biomedical research enterprise requires a constant infusion of young scientists proposing and conducting important, innovative research. Demographic analyses indicate that the biomedical research workforce has been aging…
View article: How to bring science and technology expertise to state governments
How to bring science and technology expertise to state governments Open
Science and technology (S&T) are increasingly integrated with all aspects of society. As a result, the ability to evaluate scientific information becomes ever more critical for policy and governing decisions. But such information is comple…
View article: Improving support for young biomedical scientists
Improving support for young biomedical scientists Open
A vibrant American biomedical research enterprise requires a constant infusion of young scientists proposing and conducting important, innovative research. Demographic analyses indicate that the biomedical research workforce has been aging…
View article: How the US can best support the careers of promising young biomedical scientists
How the US can best support the careers of promising young biomedical scientists Open
A vibrant American biomedical research enterprise requires a constant infusion of young scientists proposing and conducting important, innovative research. Demographic analyses indicate that the biomedical research workforce has been aging…
View article: Why All Scientists Should Promote Science Outreach
Why All Scientists Should Promote Science Outreach Open
The Next Generation Science Standards (NGSS) focus on empowering U.S. students with the skill of using evidence and logic to solve problems in the natural sciences, with an emphasis on the “practice of science”. As such, they represent a s…
View article: Publishing confirming and non-confirming data
Publishing confirming and non-confirming data Open
This editorial introduces the Preclinical Reproducibility and Robustness channel on F1000Research, which has been created to encourage and facilitate open and transparent publication and discussion of confirmatory and non-confirmatory stud…
View article: Empowering great teachers
Empowering great teachers Open
Long ago, U.S. business learned the benefits of constantly soliciting advice from workers on the shop floor by studying the startling success of the Japanese automobile industry. But the vast majority of U.S. school districts have remained…