Explanipedia

Connecting research and community: a methodological framework for investigating CMV transmission in childcare settings Open

Karen Del’Olio, Anne Geiger, Jonathan G. Terry, C. O. Callaghan, Lauren Howe , et al. · 2025

The CMV Transmission and Immune Tracking (TransmIT) Study was developed to address critical gaps in understanding of cytomegalovirus (CMV) transmission dynamics in early education and care (EEC) settings. This two-stage, community-engaged …

Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis Open

Wanzhu Tu, Samer Gawrieh, Lauren Nephew, Craig J. McClain, Qing Tang , et al. · 2025

Background: How parental alcohol use disorder and liver disease-related mortality influence the risk and the outcomes of alcohol-associated hepatitis (AH) in the offspring is unknown. Methods: We analyzed data from 2 prospective observatio…

Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure Open

Jeffrey J. Rade, Shari S. Kronsberg, Thomas S. Kickler, Ramachandran S. Vasan, Vanessa Xanthakis , et al. · 2025

Multiclass arrhythmia classification using multimodal smartwatch photoplethysmography signals collected in real-life settings Open

Dong Han, Ji-Hye Moon, Luís Roberto Mercado Díaz, Darren Chen, Devan Williams , et al. · 2024

In the early stages of atrial fibrillation (AF), most cases are paroxysmal (pAF), making identification only possible with continuous and prolonged monitoring. With the advent of wearables, smartwatches equipped with photoplethysmographic …

Multiclass arrhythmia classification using multimodal smartwatch photoplethysmography signals collected in real-life settings Open

Dong Han, Ji-Hye Moon, Luís Roberto Mercado Díaz, Darren Chen, Devan Williams , et al. · 2024

In the early stages of atrial fibrillation (AF), most cases are paroxysmal (pAF), making identification only possible with continuous and prolonged monitoring. With the advent of wearables, smartwatches equipped with photoplethysmographic …

Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository Open

John Broach, Chad J. Achenbach, S. Behar, Laurel O’Connor, Seanan Tarrant , et al. · 2024

The Infectious Diseases Clinical Research Program Acute Respiratory Infection Repository Protocol: Opportunities to Understand Current and Future Epidemics Open

Simon Pollett, Rhonda E Colombo, Stephanie A Richard, Tahaniyat Lalani, Bruce Barton , et al. · 2024

Background: Acute respiratory infections (ARI) are a major cause of morbidity and lost workdays in both military and non-military populations. To better understand these infections and their outcomes, the Infectious Diseases Clinical Resea…

Acupuncture in the emergency department (ACUITY): Results from a BraveNet multi-center feasibility randomized controlled trial Open

Jeffery A. Dusek, Gene Kallenberg, Alan B. Storrow, Robert M. Hughes, Christopher J. Coyne , et al. · 2024

In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis Open

Prashanth Thevkar Nagesh, Yeonhee Cho, Yuan Zhuang, Mrigya Babuta, Martí Ortega‐Ribera , et al. · 2024

Severe alcohol-associated hepatitis (AH) is a life-threatening form of alcohol-associated liver disease. Liver neutrophil infiltration is a hallmark of AH, yet the effects of alcohol on neutrophil functions remain elusive. Identifying ther…

Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis Open

Qiaoping Yuan, Colin A. Hodgkinson, Xiaochen Liu, Bruce Barton, Nancy Diazgranados , et al. · 2024

Background and Aims: Alcohol-associated hepatitis (AH) is a clinically severe, acute disease that afflicts only a fraction of patients with alcohol use disorder. Genomic studies of alcohol-associated cirrhosis (AC) have identified several …

Performance of and Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostics Based on Symptom Onset and Close Contact Exposure: An Analysis From the Test Us at Home Prospective Cohort Study Open

Carly Herbert, Biqi Wang, Honghuang Lin, Yan Yi, Nathaniel Hafer , et al. · 2024

Background Understanding changes in diagnostic performance after symptom onset and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure within different populations is crucial to guide the use of diagnostics for SARS-CoV-2…

Efficacy of a Multimodal Digital Behavior Change Intervention on Lifestyle Behavior, Cardiometabolic Biomarkers, and Medical Expenditure: Protocol for a Randomized Controlled Trial Open

Sakeina Howard-Wilson, Jack Ching, Sherri Gentile, Martin Ho, Alex Garcia , et al. · 2024

Background The US Preventive Services Task Force recommends providers offer individualized healthy behavior interventions for all adults, independent of their risk of cardiovascular disease. While strong evidence exists to support disease-…

Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis Open

Moyinoluwa Taiwo, Emily Huang, Vai Pathak, Annette Bellar, Nicole Welch , et al. · 2024

Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), creating an unmet need to identify noninvasive biomarkers for AH. In murine models, complement cont…

Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis Open

Samer Gawrieh, Srinivasan Dasarathy, Wanzhu Tu, Patrick S. Kamath, Naga Chalasani , et al. · 2024

Hip disarticulation in a pediatric patient with erythromelalgia Open

Bruce Barton · 2024

Technology engagement is associated with higher perceived physical well-being in stroke patients prescribed smartwatches for atrial fibrillation detection Open

Edith Mensah Otabil, Qiying Dai, Paula Anzenberg, Andreas Filippaios, Eric Ding , et al. · 2023

Background Increasing ownership of smartphones among Americans provides an opportunity to use these technologies to manage medical conditions. We examine the influence of baseline smartwatch ownership on changes in self-reported anxiety, p…

Accuracy, Usability, and Adherence of Smartwatches for Atrial Fibrillation Detection in Older Adults After Stroke: Randomized Controlled Trial Open

Eric Ding, Khanh‐Van Tran, Darleen Lessard, Ziyue Wang, Dong Han , et al. · 2023

Background Atrial fibrillation (AF) is a common cause of stroke, and timely diagnosis is critical for secondary prevention. Little is known about smartwatches for AF detection among stroke survivors. We aimed to examine accuracy, usability…

A novel score of IL-13 and age predicts 90-day mortality in severe alcohol-associated hepatitis: A multicenter plasma biomarker analysis Open

Dávid Tornai, Mack C. Mitchell, Craig J. McClain, Srinivasan Dasarathy, Arthur J. McCullough , et al. · 2023

Background: Severe alcoholic hepatitis (AH) has a high short-term mortality rate. The MELD assesses disease severity and mortality; however, it is not specific for AH. We screened plasma samples from patients with severe AH for biomarkers …

Design, Creation, and Use of The Test Us Bank (TUB) COVID-19 Sample Biorepository Open

John Broach, Chad J. Achenbach, S. Behar, Laurel O’Connor, Seanan Tarrant , et al. · 2023

Shortly after the first case of SARS-CoV-2 was diagnosed a public health emergency (PHE) was declared and a multi-agency response was initiated within the US federal government to create and propagate testing capacity. As part of this resp…

Cathepsin W, T-cell receptor-associated transmembrane adapter 1, lymphotactin and killer cell lectin like receptor K1 are sensitive and specific RNA biomarkers of canine epitheliotropic lymphoma Open

Jadesola Olayinka, Akanksha Nagarkar, Diana Junyue, Neil B. Wong, César Piedra-Mora , et al. · 2023

Cutaneous T-cell lymphoma (CTCL) is an uncommon type of lymphoma involving malignant skin-resident or skin-homing T cells. Canine epitheliotropic lymphoma (EL) is the most common form of CTCL in dogs, and it also spontaneously arises from …

Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease Open

Marko Mrdjen, Emily Huang, Vai Pathak, Annette Bellar, Nicole Welch , et al. · 2023

Background: Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is known a…

Association of neighborhood-level sociodemographic factors with Direct-to-Consumer (DTC) distribution of COVID-19 rapid antigen tests in 5 US communities Open

Carly Herbert, Qiming Shi, Jonggyu Baek, Biqi Wang, Vik Kheterpal , et al. · 2023

Background Many interventions for widescale distribution of rapid antigen tests for COVID-19 have utilized online, direct-to-consumer (DTC) ordering systems; however, little is known about the sociodemographic characteristics of home-test …

Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with <i>TP53</i> disruptions Open

Shyam A. Patel, Jan Černý, William K Gerber, Muthalagu Ramanathan, Asiri Ediriwickrema , et al. · 2023

TP53 aberrations constitute the highest risk subset of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). The International Consensus Classification questions the blast threshold between MDS and AML. In this study, we assess…

Study to Evaluate the Efficacy of a Multimodal Digital Behavior Change Intervention on Lifestyle Behavior, Cardiometabolic Biomarkers, and Medical Expenditure: Protocol of a Randomized Controlled Trial (Preprint) Open

Sakeina Howard-Wilson, Jack Ching, Sherri Gentile, Martin Ho, Alex Garcia , et al. · 2023

BACKGROUND The US Preventive Services Task Force recommends providers individualize healthy behavior interventions for all adults, independent of their risk of cardiovascular disease. OBJECTIVE We describe the protocol of randomized con…

Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection Open

Apurv Soni, Carly Herbert, Honghuang Lin, Yan Yi, Caitlin Pretz , et al. · 2023

National Institutes of Health RADx Tech program.

Efficacy of a Vibrating Crib Mattress to Reduce Pharmacologic Treatment in Opioid-Exposed Newborns Open

Elisabeth Bloch‐Salisbury, James Wilson, Nicolás Rodríguez, Tory Bruch, Lauren McKenna , et al. · 2023

Importance Pharmacologic agents are often used to treat newborns with prenatal opioid exposure (POE) despite known adverse effects on neurodevelopment. Alternative nonpharmacological interventions are needed. Objective To examine efficacy …

Anxiety, patient activation, and quality of life among stroke survivors prescribed smartwatches for atrial fibrillation monitoring Open

Tenes Paul, Khanh‐Van Tran, Jordy Mehawej, Darleen Lessard, Eric Ding , et al. · 2023

The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis Open

Vatsalya Vatsalya, Wenke Feng, Maiying Kong, Huirong Hu, Gyöngyi Szabó , et al. · 2023

INTRODUCTION: We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis. METHODS: Forty…

Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis Open

Tarek Hassanein, Craig J. McClain, Vatsalya Vatsalya, Lance L. Stein, Steven L. Flamm , et al. · 2023

INTRODUCTION: This study is to evaluate the safety and pharmacokinetics (PK) of larsucosterol (DUR-928 or 25HC3S) in subjects with alcohol-associated hepatitis (AH), a devastating acute illness without US Food and Drug Administration–appro…

Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation Open

Marcelle de Carvalho Ribeiro, Arvin Iracheta‐Vellve, Mrigya Babuta, Charles D. Calenda, Christopher Copeland , et al. · 2023

Background & Aims: Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after the cessation of alcohol use. However, mechanisms leading to this persistent inflammation remai…

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