Bruce D. Pascal
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View article: A ternary switch model governing ERα ligand binding domain conformation
A ternary switch model governing ERα ligand binding domain conformation Open
The transcription factor estrogen receptor α is the primary driver of ER+ breast cancer progression and a target of multiple FDA-approved anticancer drugs. Ligand-dependent activity of ERα is determined by helix-12 conformation within the …
View article: HXMS: a standardized file format for HX/MS data
HXMS: a standardized file format for HX/MS data Open
Motivation Hydrogen-deuterium exchange/mass spectrometry (HX/MS) is a rapidly expanding technique used to investigate protein conformational ensembles. The growing popularity and utility of HX/MS has driven the development of diverse instr…
View article: A ternary switch determines ERα LBD conformation
A ternary switch determines ERα LBD conformation Open
The transcription factor estrogen receptor α (ERα) is the primary driver of ER+ breast cancer progression and a target of multiple FDA-approved anticancer drugs. Ligand-dependent activity of ERα is determined by the conformation of helix-1…
View article: The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading Open
The innate immune receptor RIG-I provides a first line of defense against viral infections. Viral RNAs are recognized by RIG-I's C-terminal domain (CTD), but the RNA must engage the helicase domain to release the signaling CARD (Caspase Ac…
View article: RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions
RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions Open
The innate immune receptor RIG-I provides the first line of defense against viral infections. Viral RNAs are recognized by the C-terminal domain (CTD) of RIG-I, but the RNA must engage the helicase domain to release the signaling domain CA…
View article: Dual mechanism estrogen receptor inhibitors
Dual mechanism estrogen receptor inhibitors Open
Efforts to improve estrogen receptor-a (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer g…
View article: Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex Open
Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that d…
View article: Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function
Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function Open
Significance Neuronal functions of long noncoding RNAs (lncRNAs) are poorly understood. Here we describe identification and function of lncRNA GM12371 in regulating synaptic transmission, synapse density, and dendritic arborization in prim…
View article: Mass Spectrometry MSMS and HDX Raw File Data
Mass Spectrometry MSMS and HDX Raw File Data Open
In support of the publication "Irisin Mediates Effects on Bone and Fat via V Integrin Receptors", the mass spectrometry raw files for the hydrogen deuterium exchange (HDX) experiments have been made available. In addition the MSMS related …
View article: Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988
Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988 Open
Targeting peroxisome proliferator-activated receptor γ (PPARγ) by synthetic compounds has been shown to elicit insulin sensitising properties in type 2 diabetics. Treatment with a class of these compounds, the thiazolidinediones (TZDs), ha…
View article: Mass Spectrometry MSMS and HDX Raw File Data
Mass Spectrometry MSMS and HDX Raw File Data Open
In support of the publication "Irisin Mediates Effects on Bone and Fat via V Integrin Receptors", the mass spectrometry raw files for the hydrogen deuterium exchage (HDX) experiments have been made available. In addition the MSMS related f…
View article: Mass Spec Raw File Data
Mass Spec Raw File Data Open
Here we report HDX raw files supporting the manuscript "Regulator of G-protein signaling, GPCR signaling, neurotransmitter signaling, crystal structure, Hydrogen-deuterium exchange mass-spectrometry (HDX)". The raw file sets are packaged i…
View article: Mass Spec Raw File Data
Mass Spec Raw File Data Open
Here we report HDX raw files supporting the manuscript "Regulator of G-protein signaling, GPCR signaling, neurotransmitter signaling, crystal structure, Hydrogen-deuterium exchange mass-spectrometry (HDX)". The raw file sets are packaged i…
View article: RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum Open
Protein interaction networks of the GTPase Rhes regulate motor control in the striatum.