G. Bruce Pike
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View article: The effects of contextual bias on face recognition decisions
The effects of contextual bias on face recognition decisions Open
Contemporary research has demonstrated the effects of bias on, even expert, forensic decision making. The paper aimed to test if forensically relevant face recognition decisions could be influenced by biasing information. A 3 (Bias (within…
View article: SUSEP-Net: Simulation-Supervised and Contrastive Learning-based Deep Neural Networks for Susceptibility Source Separation
SUSEP-Net: Simulation-Supervised and Contrastive Learning-based Deep Neural Networks for Susceptibility Source Separation Open
Quantitative susceptibility mapping (QSM) provides a valuable tool for quantifying susceptibility distributions in human brains; however, two types of opposing susceptibility sources (i.e., paramagnetic and diamagnetic), may coexist in a s…
View article: Physiological Confounds in BOLD‐fMRI and Their Correction
Physiological Confounds in BOLD‐fMRI and Their Correction Open
Functional magnetic resonance imaging (fMRI) has opened new frontiers in neuroscience by instrumentally driving our understanding of brain function and development. Despite its substantial successes, fMRI studies persistently encounter obs…
View article: P.198 Outcomes and connectivity changes in treatment-resistant OCD after MR-guided focused ultrasound capsulotomy
P.198 Outcomes and connectivity changes in treatment-resistant OCD after MR-guided focused ultrasound capsulotomy Open
Background: Treatment-resistant obsessive compulsive disorder (trOCD) is a condition characterized by intrusive thoughts (obsessions) and uncontrollable behaviours (compulsions) unresponsive to conventional therapies. Lesioning both anteri…
View article: Direct Estimation of Pediatric Heart Rate Variability from BOLD-fMRI: A Machine Learning Approach Using Dynamic Connectivity
Direct Estimation of Pediatric Heart Rate Variability from BOLD-fMRI: A Machine Learning Approach Using Dynamic Connectivity Open
In many pediatric fMRI studies, cardiac signals are often missing or of poor quality. A tool to extract Heart Rate Variation (HRV) waveforms directly from fMRI data, without the need for peripheral recording devices, would be highly benefi…
View article: Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging
Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging Open
The alteration of neurovascular coupling (NVC), where acute localized blood flow increases following neural activity, plays a key role in several neurovascular processes including aging and neurodegeneration. While not equivalent to NVC, t…
View article: An Eight-Channel MRI Head Coil Array for Enhanced MRI-Guided Transcranial Focused Ultrasound Imaging Performance
An Eight-Channel MRI Head Coil Array for Enhanced MRI-Guided Transcranial Focused Ultrasound Imaging Performance Open
Magnetic resonance guided focused ultrasound (MRgFUS) thermal ablation is a new method of non-invasive neurosurgery that can benefit from improved MR imaging performance. The ultrasound transducer shields the radio-frequency field of the b…
View article: Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI
Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI Open
The g-ratio of a myelinated axon is defined as the ratio of the inner-to-outer diameter of the myelin sheath and modulates conduction speed of action potentials along axons. This g-ratio can be mapped in vivo at the macroscopic scale acros…
View article: Cognitive, Behavioral, and Functional Outcomes of Suspected Mild Traumatic Brain Injury in Community-Dwelling Older Persons Without Mild Cognitive Impairment or Dementia
Cognitive, Behavioral, and Functional Outcomes of Suspected Mild Traumatic Brain Injury in Community-Dwelling Older Persons Without Mild Cognitive Impairment or Dementia Open
smTBI at any point in the life course is linked to poorer cognition and behavior even in community-dwelling older persons without MCI or dementia. Older persons with smTBI may benefit from early dementia risk assessment using tools that me…
View article: Cognitive, behavioral, and functional outcomes of suspected mild traumatic brain injury in community‐dwelling older persons without mild cognitive impairment or dementia
Cognitive, behavioral, and functional outcomes of suspected mild traumatic brain injury in community‐dwelling older persons without mild cognitive impairment or dementia Open
Background Traumatic brain injury (TBI) is a risk factor for dementia and is linked to earlier age of onset. This study investigated whether later‐life changes in everyday cognition and behavior – risk markers of AD – could be observed in …
View article: Machine learning‐based estimation of respiratory fluctuations in a healthy adult population using resting state <scp>BOLD fMRI</scp> and head motion parameters
Machine learning‐based estimation of respiratory fluctuations in a healthy adult population using resting state <span>BOLD fMRI</span> and head motion parameters Open
Purpose External physiological monitoring is the primary approach to measure and remove effects of low‐frequency respiratory variation from BOLD‐fMRI signals. However, the acquisition of clean external respiratory data during fMRI is not a…
View article: The Useful Side of Motion: Using Head Motion Parameters to Correct for Respiratory Confounds in BOLD fMRI
The Useful Side of Motion: Using Head Motion Parameters to Correct for Respiratory Confounds in BOLD fMRI Open
Acquiring accurate external respiratory data during functional Magnetic Resonance Imaging (fMRI) is challenging, prompting the exploration of machine learning methods to estimate respiratory variation (RV) from fMRI data. Respiration induc…
View article: Analysis and visualization of the effect of multiple sclerosis on biological brain age
Analysis and visualization of the effect of multiple sclerosis on biological brain age Open
Introduction The rate of neurodegeneration in multiple sclerosis (MS) is an important biomarker for disease progression but can be challenging to quantify. The brain age gap, which quantifies the difference between a patient's chronologica…
View article: Linking cognitive and behavioral reserve: Evidence from the CAN‐PROTECT study
Linking cognitive and behavioral reserve: Evidence from the CAN‐PROTECT study Open
INTRODUCTION Changes to the brain due to Alzheimer's disease and other age‐related neuropathologies may present with cognitive and behavioral symptoms, even during preclinical and prodromal stages. While cognitive reserve is known to mitig…
View article: Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI
Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI Open
The g-ratio of a myelinated axon is defined as the ratio of the inner-to-outer diameter of the myelin sheath and modulates conduction speed of action potentials along axons. This g-ratio can be mapped in vivo at the macroscopic scale acros…
View article: Properties of the prefrontal tracts and cingulum bundle in children with prenatal alcohol exposure
Properties of the prefrontal tracts and cingulum bundle in children with prenatal alcohol exposure Open
PAE may be weakly associated with restricted diffusion in the right parahippocampal cingulum and multiple intra-frontal tracts. However, diffusivity changes related to PAE might not be the primary contributor to emotional and behavioural c…
View article: Neuropsychiatric symptoms: Risk factor or disease marker? A study of structural imaging biomarkers of Alzheimer's disease and incident cognitive decline
Neuropsychiatric symptoms: Risk factor or disease marker? A study of structural imaging biomarkers of Alzheimer's disease and incident cognitive decline Open
Neuropsychiatric symptoms (NPS) are risk factors for Alzheimer's disease (AD) but can also manifest secondary to AD pathology. Mild behavioral impairment (MBI) refers to later‐life emergent and persistent NPS that may mark early‐stage AD. …
View article: A systematic review of preclinical and clinical transcranial ultrasound neuromodulation and opportunities for functional connectomics
A systematic review of preclinical and clinical transcranial ultrasound neuromodulation and opportunities for functional connectomics Open
Ultrasound neuromodulation has emerged as a powerful tool to study and treat a range of conditions and its combination with various neural readouts has significantly advanced this platform. In particular, the use of functional magnetic res…
View article: Fast magnetization transfer saturation imaging of the brain using <scp>MP2RAGE T<sub>1</sub></scp> mapping
Fast magnetization transfer saturation imaging of the brain using <span>MP2RAGE T<sub>1</sub></span> mapping Open
Purpose Magnetization transfer saturation (MT sat ) mapping is commonly used to examine the macromolecular content of brain tissue. This study compared variable flip angle (VFA) T 1 mapping against compressed‐sensing MP2RAGE (csMP2RAGE) T …
View article: Machine Learning-based Estimation of Respiratory Fluctuations in a Healthy Adult Population using BOLD fMRI and Head Motion Parameters
Machine Learning-based Estimation of Respiratory Fluctuations in a Healthy Adult Population using BOLD fMRI and Head Motion Parameters Open
Motivation: In many fMRI studies, respiratory signals are often missing or of poor quality. Therefore, it could be highly beneficial to have a tool to extract respiratory variation (RV) waveforms directly from fMRI data without the need fo…
View article: Plug-and-Play latent feature editing for orientation-adaptive quantitative susceptibility mapping neural networks
Plug-and-Play latent feature editing for orientation-adaptive quantitative susceptibility mapping neural networks Open
Quantitative susceptibility mapping (QSM) is a post-processing technique for deriving tissue magnetic susceptibility distribution from MRI phase measurements. Deep learning (DL) algorithms hold great potential for solving the ill-posed QSM…
View article: The effect of transcranial ultrasound pulse repetition frequency on sustained inhibition in the human primary motor cortex: A double-blind, sham-controlled study
The effect of transcranial ultrasound pulse repetition frequency on sustained inhibition in the human primary motor cortex: A double-blind, sham-controlled study Open
This study highlights the significance of PRF selection in TUS and underscores its potential as a non-invasive approach to reduce corticospinal excitability, offering valuable insights for future clinical applications.
View article: Ultrasound and neuroinflammation: immune modulation via the heat shock response
Ultrasound and neuroinflammation: immune modulation via the heat shock response Open
Current pharmacological therapeutic approaches targeting chronic inflammation exhibit transient efficacy, often with adverse effects, limiting their widespread use - especially in the context of neuroinflammation. Effective interventions r…
View article: Further along the Alzheimer’s disease continuum: associations between mild behavioral impairment with hippocampal and entorhinal volume and incident cognitive decline
Further along the Alzheimer’s disease continuum: associations between mild behavioral impairment with hippocampal and entorhinal volume and incident cognitive decline Open
Background Mild behavioral impairment (MBI) identifies a high‐risk group for Alzheimer’s disease and related dementias (ADRD), leveraging the risk associated with later‐life emergent and persistent neuropsychiatric symptoms (NPS). MBI may …