Bruce J. Paster
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View article: Engineered Tissue Models to Decode Host–Microbiota Interactions
Engineered Tissue Models to Decode Host–Microbiota Interactions Open
A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but also contribut…
View article: Subgingival Microbiome of Type 2 diabetic subjects associated with Periodontal Severity and Metabolic Condition
Subgingival Microbiome of Type 2 diabetic subjects associated with Periodontal Severity and Metabolic Condition Open
Type 2 diabetes and its risk factors such as dyslipidemia and/or obesity enhance severe periodontitis with a poorly understood microbiome. Hence, the purpose of the present study was to describe and compare the subgingival microbiomes of T…
View article: Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (<scp>ORIGINS</scp>)
Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (<span>ORIGINS</span>) Open
Objective To study the association between dietary patterns and subgingival microbiota. Methods Participants ( n = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival …
View article: Dietary nitrate intake and net nitrite-generating capacity of the oral microbiome interact to enhance cardiometabolic health: Results from the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS)
Dietary nitrate intake and net nitrite-generating capacity of the oral microbiome interact to enhance cardiometabolic health: Results from the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS) Open
Background We investigated the association between dietary nitrate intake and early clinical cardiometabolic risk biomarkers, and explored whether the oral microbiome modifies the association between dietary nitrate intake and cardiometabo…
View article: Oral and gut microbial profiling in periodontitis and Parkinson’s disease
Oral and gut microbial profiling in periodontitis and Parkinson’s disease Open
No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
View article: Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes
Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes Open
Aim We investigated whether periodontal measures are cross‐sectionally associated with prediabetes and cardiometabolic biomarkers among non‐diabetic younger adults. Materials and Methods One thousand seventy‐one participants (mean age = 32…
View article: Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model
Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model Open
Host-oral microbiome interactions are known to be critical in maintaining local and systemic health of the human body, although they are difficult to study in both clinical and in vitro applications. Despite efforts, recapitulation of ging…
View article: Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging
Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging Open
INTRODUCTION We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancilla…
View article: Parkinson’s disease alters the composition of subgingival microbiome
Parkinson’s disease alters the composition of subgingival microbiome Open
These data demonstrated that Parkinson's disease modifies PD-associated subgingival microbiome.
View article: Metabolomic profiles of obesity and subgingival microbiome in periodontally healthy individuals: A cross‐sectional study
Metabolomic profiles of obesity and subgingival microbiome in periodontally healthy individuals: A cross‐sectional study Open
Aim Since blood metabolomic profiles of obese individuals are known to be altered, our objective was to examine the association between obesity‐related metabolic patterns and subgingival microbial compositions in obese and non‐obese period…
View article: Microglial cell response to experimental periodontal disease
Microglial cell response to experimental periodontal disease Open
Objectives Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in forming barriers around e…
View article: Impact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis
Impact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis Open
This study aimed to evaluate the impact of Nystatin oral rinse on salivary and supragingival microbiota in adults with oral candidiasis and identify predictive factors related to individuals’ responses to Nystatin. The trial involved twent…
View article: <i>Fusobacterium nucleatum</i> dissemination by neutrophils
<i>Fusobacterium nucleatum</i> dissemination by neutrophils Open
Recent studies uncovered that Fusobacterium nucleatum (Fn), a common, opportunistic bacterium in the oral cavity, is associated with a growing number of systemic diseases, ranging from colon cancer to Alzheimer's disease. However, the path…
View article: Dental caries and their microbiomes in children: what do we do now?
Dental caries and their microbiomes in children: what do we do now? Open
The oral cavity is an unique ecosystem formed by different structures, tissues, and a complex microbial community formed by hundreds of different species of bacteria, fungi, viruses, phages, and the candidate phyla radiation (CPR) group, a…
View article: Data from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Data from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Background: The human upper digestive tract microbial community (microbiota) is not well characterized and few studies have explored how it relates to human health. We examined the relationship between upper digestive tract microbiota and …
View article: Supplemental Figure 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Supplemental Figure 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Subjects grouped into clusters (designated as A, B, C) by the UniFrac distance matrix according to the UPGMA method. Note that the figure was constructed from 659 subjects. We included 333 subjects for this study because we did not have se…
View article: supplemental table 2 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
supplemental table 2 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Odds ratio and 95% confidence intervals for the associations between presence/absence of individual strain/species and PGI/II ratio
View article: Supplemental Figure 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Supplemental Figure 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Subjects grouped into clusters (designated as A, B, C) by the UniFrac distance matrix according to the UPGMA method. Note that the figure was constructed from 659 subjects. We included 333 subjects for this study because we did not have se…
View article: Data from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Data from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Background: The human upper digestive tract microbial community (microbiota) is not well characterized and few studies have explored how it relates to human health. We examined the relationship between upper digestive tract microbiota and …
View article: supplemental table 2 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
supplemental table 2 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Odds ratio and 95% confidence intervals for the associations between presence/absence of individual strain/species and PGI/II ratio
View article: Supplemental table 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Supplemental table 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Odds ratio and 95% confidence intervals for the associations between presence of individual strain/species and Esophageal Squamous Dysplasia (ESD) status
View article: Supplemental table 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach
Supplemental table 1 from Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach Open
Odds ratio and 95% confidence intervals for the associations between presence of individual strain/species and Esophageal Squamous Dysplasia (ESD) status
View article: Dynamics of oral microbiome acquisition in healthy infants: A pilot study
Dynamics of oral microbiome acquisition in healthy infants: A pilot study Open
Objectives The human oral microbiota is one of the most complex bacterial communities in the human body. However, how newborns initially acquire these bacteria remains largely unknown. In this study, we examined the dynamics of oral microb…
View article: Novel Clustering Methods Identified Three Caries Status-Related Clusters Based on Oral Microbiome in Thai Mother–Child Dyads
Novel Clustering Methods Identified Three Caries Status-Related Clusters Based on Oral Microbiome in Thai Mother–Child Dyads Open
Early childhood caries (ECC) is a disease that globally affects pre-school children. It is important to identify both protective and risk factors associated with this disease. This paper examined a set of saliva samples of Thai mother–chil…
View article: Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls
Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls Open
Oral microbiomes of IE, non-IE disease controls, and healthy controls differed significantly. A better understanding of IE-related bacterial-host interactions is warranted.
View article: Microbiota present in combined endodontic-periodontal diseases and its risks for endocarditis
Microbiota present in combined endodontic-periodontal diseases and its risks for endocarditis Open
Introduction: Infective endocarditis (IE) is an inflammatory disease usually caused by bacteria that enter the bloodstream and settle in the inner linings or valves of the heart, as well as in blood vessels. Despite modern antimicrobial an…
View article: A new family for ‘termite gut treponemes’: description of Breznakiellaceae fam. nov., Gracilinema caldarium gen. nov., comb. nov., Leadbettera azotonutricia gen. nov., comb. nov., Helmutkoenigia isoptericolens gen. nov., comb. nov., and Zuelzera stenostrepta gen. nov., comb. nov., and proposal of Rectinemataceae fam. nov.
A new family for ‘termite gut treponemes’: description of Breznakiellaceae fam. nov., Gracilinema caldarium gen. nov., comb. nov., Leadbettera azotonutricia gen. nov., comb. nov., Helmutkoenigia isoptericolens gen. nov., comb. nov., and Zuelzera stenostrepta gen. nov., comb. nov., and proposal of Rectinemataceae fam. nov. Open
The intestinal tracts of termites are abundantly colonized by a diverse assemblage of spirochetes. Most of them belong to ‘termite cluster I’, a monophyletic group within the radiation of the genus Treponema that occurs exclusively in term…