Bruce Kaplan
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View article: Evaluation of the OPTN Six-Status Heart Allocation System and a Combined Prognostic Model for Waitlist Risk Evaluation
Evaluation of the OPTN Six-Status Heart Allocation System and a Combined Prognostic Model for Waitlist Risk Evaluation Open
KEY POINTS Question Does the current national six-status heart allocation system rank waitlisted transplant patients based on medical urgency? Can this heart allocation system’s prognostic performance be improved? Findings The six-status s…
View article: Assessment of the elasticity of lipedematous tissue and the examination of the relationship between pain and fibrosis in lipedema
Assessment of the elasticity of lipedematous tissue and the examination of the relationship between pain and fibrosis in lipedema Open
Background/Objectives: Lipedema is a chronic and progressive adipose tissue disorder characterized by the abnormal accumulation of subcutaneous fat, predominantly in the legs and occasionally in the arms. The symptom that most significantl…
View article: Cognitive Impairment in CMV Seropositive and CMV Seronegative Deceased Donor Kidney Transplant Recipients
Cognitive Impairment in CMV Seropositive and CMV Seronegative Deceased Donor Kidney Transplant Recipients Open
Background. Kidney transplant recipients (KTRs) experience a high burden of cytomegalovirus infection (CMV R + ) and long-term premature cognitive aging. We tested whether CMV was associated with post-KT cognitive impairment. Methods. In a…
View article: Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation
Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation Open
Background. Donation after circulatory death liver transplantation (DCD LT) is underused given historical outcomes fraught with ischemic cholangiopathy (IC). We aimed to assess 6-mo IC in LT from DCD via normothermic regional perfusion (NR…
View article: Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants
Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants Open
Background This study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the av…
View article: The Colorado Heart Failure Acuity Risk Model
The Colorado Heart Failure Acuity Risk Model Open
View article: Area-Level Social Deprivation and Cytomegalovirus Seropositivity at the Time of Solid Organ Transplant
Area-Level Social Deprivation and Cytomegalovirus Seropositivity at the Time of Solid Organ Transplant Open
Importance Cytomegalovirus (CMV) is associated with significant morbidity and mortality in solid organ transplant (SOT) recipients. The risk factors for CMV seropositivity in SOT recipients, including area-level social deprivation in the U…
View article: Calibration of Priority Points for Sensitization Status of Kidney Transplant Candidates in the United States
Calibration of Priority Points for Sensitization Status of Kidney Transplant Candidates in the United States Open
Key Points There are multiple factors associated with high sensitization levels among kidney transplant candidates, which differ by candidate sex. Since the initiation of the kidney allocation system, candidates with higher sensitization h…
View article: Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States
Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States Open
Key Points Nationally, 41% of kidney transplant candidates consented to receive high–Kidney Donor Profile Index (KDPI) donor offers in the United States. There was wide variation in consent proportion for high-KDPI donors on the basis of i…
View article: Patient years lost due to cytomegalovirus serostatus mismatching in the scientific registry of transplant recipients
Patient years lost due to cytomegalovirus serostatus mismatching in the scientific registry of transplant recipients Open
Background The cytomegalovirus (CMV) mismatch rate in deceased donor kidney transplant (DDKT) recipients in the US remains above 40%. Since CMV mismatching is common in DDKT recipients, the cumulative effects may be significant in the cont…
View article: Differential in Kidney Graft Years on the Basis of Solitary Kidney, Simultaneous Liver–Kidney, and Kidney-after-Liver Transplants
Differential in Kidney Graft Years on the Basis of Solitary Kidney, Simultaneous Liver–Kidney, and Kidney-after-Liver Transplants Open
Background The number of simultaneous liver–kidney (SLK) transplants has significantly increased in the United States. There has also been an increase in kidney-after-liver transplants associated with 2017 policy revisions aimed to fairly …
View article: The Colorado Heart Failure Acuity Risk Model (CHARM) Score: A Mortality Risk Model for Waitlisted Cardiac Transplant Patients
The Colorado Heart Failure Acuity Risk Model (CHARM) Score: A Mortality Risk Model for Waitlisted Cardiac Transplant Patients Open
Importance Although the Organ Procurement and Transplantation network provides structured policies and guidance for waitlisted cardiac transplant patients, the heart transplantation community lacks a mathematical model that can accurately …
View article: An evaluation of the organ procurement and transplantation network's expanded post-transplant performance metrics
An evaluation of the organ procurement and transplantation network's expanded post-transplant performance metrics Open
On July 14, 2022, the Organ Procurement and Transplantation Network's (OPTN) Membership and Professional Standards Committee (MPSC) approved bylaws including two new post-transplant performance evaluation metrics, the 90-day (90D) and 1-ye…
View article: Reassessing the survival benefit of deceased donor liver transplantation: retrospective cohort study
Reassessing the survival benefit of deceased donor liver transplantation: retrospective cohort study Open
Introduction: Currently in the United States, deceased donor liver transplant (DDLT) allocation priority is based on the model for end-stage liver disease including sodium (MELD-Na) score. The United Network for organ sharing’s ‘Share-15’ …
View article: Deceased donor kidneys from higher distressed communities are significantly less likely to be utilized for transplantation
Deceased donor kidneys from higher distressed communities are significantly less likely to be utilized for transplantation Open
View article: A model for calculating the long-term estimated post-transplant survival of deceased donor liver transplant patients
A model for calculating the long-term estimated post-transplant survival of deceased donor liver transplant patients Open
There are no funding sources related to this project.
View article: Review of: "Improving agriculture and food security in Africa: Can the one health approach be the answer?"
Review of: "Improving agriculture and food security in Africa: Can the one health approach be the answer?" Open
View article: Postoperative fibrinolytic resistance is associated with early allograft dysfunction in liver transplantation: A prospective observational study
Postoperative fibrinolytic resistance is associated with early allograft dysfunction in liver transplantation: A prospective observational study Open
Perioperative dysfunction of the fibrinolytic system may play a role in adverse outcomes for liver transplant recipients. There is a paucity of data describing the potential impact of the postoperative fibrinolytic system on these outcomes…
View article: EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT
EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT Open
Current economic, social, and environmental trajectories within most world regions are unsustainable. Interaction between bottom-up initiatives and top-down good governance is essential to change them. The One Health movement, made up of m…
View article: EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT
EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT Open
Current economic, social, and environmental trajectories within most world regions are unsustainable. Interaction between bottom-up initiatives and top-down good governance is essential to change them. The One Health movement, made up of m…
View article: FACTORs: a Novel R Package for Functional Data Reduction and Hypothesis Testing
FACTORs: a Novel R Package for Functional Data Reduction and Hypothesis Testing Open
To extract biological meaning from transcriptomics analysis, investigators almost exclusively rely on biological annotation databases and the subsequent associations made between gene products and ontology terms (i.e., gene ontology analys…
View article: Survival Benefit of Living-Donor Liver Transplant
Survival Benefit of Living-Donor Liver Transplant Open
Importance Despite the acceptance of living-donor liver transplant (LDLT) as a lifesaving procedure for end-stage liver disease, it remains underused in the United States. Quantification of lifetime survival benefit and the Model for End-s…
View article: Vaccination, Transplantation, and a Social Contract
Vaccination, Transplantation, and a Social Contract Open
The effect of coronavirus disease 2019 (COVID-19) in transplantation has triggered a debate over pretransplant vaccination requirements, which has several layers. First, is vaccination right, in the sense that it is supported by persuasive…
View article: A Model for Calculating the Long-Term Estimated Post-Transplant Survival of Deceased Donor Liver Transplant Patients
A Model for Calculating the Long-Term Estimated Post-Transplant Survival of Deceased Donor Liver Transplant Patients Open
View article: Need for a Validation Study before Using the Two-Step Algorithm for dd-cfDNA to Screen for Acute Rejection
Need for a Validation Study before Using the Two-Step Algorithm for dd-cfDNA to Screen for Acute Rejection Open
The study by Bunnapradist et al. [1][1] proposes using a two-step algorithm threshold for donor derived cell free DNA (dd-cfDNA) to increase sensitivity for detection of acute rejection. Although this hypothesis is both tenable and biologi…
View article: Understanding Risks and Our Responsibility to Living Donors
Understanding Risks and Our Responsibility to Living Donors Open
Nearly 70 years after the first living donor kidney transplant, the practice of living donation continues despite incomplete information about the long-term risks of donation and the absence of resources for lifelong postdonation care. As …
View article: High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation Open
View article: Transplant administration—A survey of the roles and responsibilities of kidney and pancreas medical directors of US transplant centers
Transplant administration—A survey of the roles and responsibilities of kidney and pancreas medical directors of US transplant centers Open
The current American Society of Transplantation (AST) accredited transplant fellowship programs in the United States provide no structured formal training in leadership and administration which is essential for successfully running a trans…
View article: Artificial Intelligence-related Literature in Transplantation: A Practical Guide
Artificial Intelligence-related Literature in Transplantation: A Practical Guide Open
INTRODUCTION Since John McCarthy introduced the term “artificial intelligence (AI)” in 1955,1 AI research has been growing. “AI” is an umbrella term that encompasses a vast degree of computer technologies (eg, expert systems, computer visi…
View article: The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020
The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020 Open
The impact of the COVID-19 pandemic is very wide and occupies almost every aspect of life across the world with the wave of direct health impacts cutting across each nation at different paces. The impact on the economies of all countries h…