Bruce Klitzman
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View article: Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts
Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts Open
Acute respiratory failure with inadequate oxygenation and/or ventilation is a common reason for ICU admission in children and adults. Despite the morbidity and mortality associated with acute respiratory failure, few proven treatment optio…
View article: The Influence of Topical Vasodilator-Induced Pharmacologic Delay on Cutaneous Flap Viability and Vascular Remodeling
The Influence of Topical Vasodilator-Induced Pharmacologic Delay on Cutaneous Flap Viability and Vascular Remodeling Open
Background: Surgical delay is a well-described technique to improve survival of random and pedicled cutaneous flaps. The aim of this study was to test the topical agents minoxidil and iloprost as agents of pharmacologic delay to induce vas…
View article: Bioburden after Staphylococcus aureus Inoculation in Type 1 Diabetic Rats Undergoing Internal Fixation
Bioburden after Staphylococcus aureus Inoculation in Type 1 Diabetic Rats Undergoing Internal Fixation Open
Fracture stabilization in the diabetic patient is associated with higher complication rates, particularly infection and impaired wound healing, which can lead to major tissue damage, osteomyelitis, and higher amputation rates. With an incr…
View article: The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants
The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants Open
Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates with varying NO rel…
View article: Reduced foreign body response at nitric oxide-releasing subcutaneous implants
Reduced foreign body response at nitric oxide-releasing subcutaneous implants Open
The tissue response to nitric oxide (NO)-releasing subcutaneous implants is presented. Model implants were created by coating silicone elastomer with diazeniumdiolate-modified xerogel polymers capable of releasing NO. The host tissue respo…
View article: Increased In Vivo Glucose Recovery via Nitric Oxide Release
Increased In Vivo Glucose Recovery via Nitric Oxide Release Open
The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant NO flux of …
View article: Development of a novel intravascular oxygenator catheter: Oxygen mass transfer properties across nonporous hollow fiber membranes
Development of a novel intravascular oxygenator catheter: Oxygen mass transfer properties across nonporous hollow fiber membranes Open
Despite hypoxic respiratory failure representing a large portion of total hospitalizations and healthcare spending worldwide, therapeutic options beyond mechanical ventilation are limited. We demonstrate the technical feasibility of provid…
View article: 4511 Bio-Compatible Implantable Oxygen Sensor Technology with Real-Time Monitoring of Surgical Flaps and Reimplantation
4511 Bio-Compatible Implantable Oxygen Sensor Technology with Real-Time Monitoring of Surgical Flaps and Reimplantation Open
OBJECTIVES/GOALS: Current surgical flap and replantation monitoring techniques have limitations in detecting the pathologic state, calibration and cost-to-patient issues. Our hypothesis is that novel implantable oxygen sensors can provide …
View article: Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model
Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model Open
Background. Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy in liver transplantation, but the optimal methods for assessing liver grafts during this period have not been determined. The aim of this study w…
View article: Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers
Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers Open
Measurements of regional tissue oxygen serve as a proxy to monitor local perfusion and have the potential to guide therapeutic decisions in multiple clinical disciplines. Transcutaneous oximetry (tcpO2) is a commercially available noninvas…
View article: Enhanced Drug Delivery to the Skin Using Liposomes
Enhanced Drug Delivery to the Skin Using Liposomes Open
Background: Enhancing drug delivery to the skin has importance in many therapeutic strategies. In particular, the outcome in vascularized composite allotransplantation mainly depends on systemic immunosuppression to prevent and treat episo…
View article: Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut Open
How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed how antibiotics, …
View article: Author response: Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut
Author response: Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract How host and microbial factor…
View article: Abstract 144: Which Is More Ideal To Monitor And Detect Flap Vascular Compromise: Intradermal Or Subcutaneous Tissue Oxygen Tension?
Abstract 144: Which Is More Ideal To Monitor And Detect Flap Vascular Compromise: Intradermal Or Subcutaneous Tissue Oxygen Tension? Open
PURPOSE: The ideal monitoring tool to evaluate free flap success should be minimally invasive, continuous, cost-effective and reliable. Our group has previously introduced implantable oxygen sensors as a mean to monitor flaps in the immedi…
View article: Abstract 111: Rapid Detection of Acute Vascular Occlusion Using Oxygen Monitoring in a Rat Myocutaneous Flap Model
Abstract 111: Rapid Detection of Acute Vascular Occlusion Using Oxygen Monitoring in a Rat Myocutaneous Flap Model Open
PURPOSE: Free tissue transfer requires close postoperative monitoring for vascular occlusion. Vascular compromise commonly occurs in the immediate postoperative period in association with failure of the micro-vascular anastomosis. The resi…
View article: Abstract P13: Implantable Real Time Oxygen Biosensors for Detection of Vascular Perfusion and Ischemia
Abstract P13: Implantable Real Time Oxygen Biosensors for Detection of Vascular Perfusion and Ischemia Open
PURPOSE: Even with vast improvements in techniques and instrumentation, tissue non-viability due to a lack of adequate perfusion and oxygenation still remains a problem in many surgical settings, including free tissue transfer and non-heal…
View article: Abstract P15: Comparison Of Intradermal And Subcutaneous Tissue Oxygen Tension Monitor To Detect Flap Compromise
Abstract P15: Comparison Of Intradermal And Subcutaneous Tissue Oxygen Tension Monitor To Detect Flap Compromise Open
PURPOSE: The ideal monitoring tool to evaluate free flap success should be minimally invasive, continuous, cost-effective and reliable. Our group has previously introduced implantable oxygen sensors as a mean to monitor flaps in the immedi…
View article: Abstract 41: Implantable Oxygen Biosensor Reveals Post-Occlusion Tissue Reactive Hyperoxia
Abstract 41: Implantable Oxygen Biosensor Reveals Post-Occlusion Tissue Reactive Hyperoxia Open
INTRODUCTION: This study utilized an implantable biosensor to measure tissue oxygenation before, during, and after a transient ischemic insult. The purpose of this study was to use implantable O2 sensors to quantify local O2 content follow…
View article: MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS
MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS Open
You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I1 Apr 2016MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS Mohamed Ib…
View article: 472. Low-Shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-Derived Stromal-Vascular Fraction
472. Low-Shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-Derived Stromal-Vascular Fraction Open
Impaired wound healing occurs in various pathologies and is characterized by diminished substrate delivery, inadequate cellular proliferation and tissue fibrosis. The cellular constituents of the adipose-derived stromal-vascular fraction (…