Bruce A. McDonald
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View article: <i>Zymoseptoria tritici</i> stealth infection is facilitated by stage‐specific downregulation of a β‐glucanase
<i>Zymoseptoria tritici</i> stealth infection is facilitated by stage‐specific downregulation of a β‐glucanase Open
Summary Plant cell walls constitute a major defence barrier against pathogens, although it is unclear how specific cell wall components impact pathogen colonisation. Pathogens secrete cell wall‐degrading enzymes (CWDEs) to facilitate plant…
View article: Tracking Lesion Growth in the Field: Imaging and Deep Learning Reveal Components of Quantitative Resistance
Tracking Lesion Growth in the Field: Imaging and Deep Learning Reveal Components of Quantitative Resistance Open
Summary Measuring individual components of pathogen reproduction is key to understanding mechanisms underlying rate-reducing quantitative resistance (QR). Simulation models predict that lesion expansion plays a key role in seasonal epidemi…
View article: From Canopy Images to Organ-Level Disease Assessments: A Scalable Approach to Measure Quantitative Resistance in the Field
From Canopy Images to Organ-Level Disease Assessments: A Scalable Approach to Measure Quantitative Resistance in the Field Open
Breeding for quantitative, polygenic resistance is widely considered the most durable, cost-effective, and environmentally safe approach to crop disease control. However, progress in resistance breeding is hindered by the limited capabilit…
View article: Mapping genomic regions associated with temperature stress in the wheat pathogen <i>Zymoseptoria tritici</i>
Mapping genomic regions associated with temperature stress in the wheat pathogen <i>Zymoseptoria tritici</i> Open
Climate change can alter interactions between plants and their pathogens, which could adversely affect crop production. To better understand the molecular mechanisms underlying the responses of pathogenic fungi to temperature stress, we co…
View article: How knowledge of pathogen population biology informs management of Septoria nodorum blotch on wheat
How knowledge of pathogen population biology informs management of Septoria nodorum blotch on wheat Open
Septoria nodorum blotch (SNB) of wheat is caused by a complex of related fungi that infect both leaves and ears. The most intensively studied member of the species complex is Parastagonospora nodorum, which causes the majority of SNB. Whil…
View article: A Genome-Wide Association Study Identifies Markers and Candidate Genes Affecting Tolerance to the Wheat Pathogen <i>Zymoseptoria tritici</i>
A Genome-Wide Association Study Identifies Markers and Candidate Genes Affecting Tolerance to the Wheat Pathogen <i>Zymoseptoria tritici</i> Open
Plants defend themselves against pathogens using either resistance, measured as the host's ability to limit pathogen multiplication, or tolerance, measured as the host's ability to reduce the negative effects of infection. Tolerance is a p…
View article: Thermal Adaptation in Worldwide Collections of a Major Fungal Pathogen
Thermal Adaptation in Worldwide Collections of a Major Fungal Pathogen Open
Adaptation to new climates poses a significant challenge for plant pathogens during range expansion, highlighting the importance of understanding their response to climate to accurately forecast future disease outbreaks. The wheat pathogen…
View article: Responses to temperature shocks in<i>Zymoseptoria tritici</i>reveal specific transcriptional reprogramming and novel candidate genes for thermal adaptation
Responses to temperature shocks in<i>Zymoseptoria tritici</i>reveal specific transcriptional reprogramming and novel candidate genes for thermal adaptation Open
Pathogens’ responses to sudden temperature fluctuations, spanning various temporal scales, are critical determinants of their survival, growth, reproduction, and homeostasis. Here, we combined phenotyping, transcriptomics, and genome-wide …
View article: <i>Zymoseptoria tritici</i>stealth infection is facilitated by stage-specific down-regulation of a β-glucanase
<i>Zymoseptoria tritici</i>stealth infection is facilitated by stage-specific down-regulation of a β-glucanase Open
Plant cell walls constitute a major defence barrier against pathogens, although it is unclear how specific cell wall components impact pathogen colonisation. Pathogens secrete cell wall degrading enzymes (CWDEs) to facilitate plant colonis…
View article: Mapping genomic regions associated with temperature stress in the wheat pathogen<i>Zymoseptoria tritici</i>
Mapping genomic regions associated with temperature stress in the wheat pathogen<i>Zymoseptoria tritici</i> Open
Climate change can alter interactions between plants and their pathogens, which could adversely affect crop production. To better understand the molecular mechanisms underlying the responses of pathogenic fungal to temperature stress, we c…
View article: Thermal adaptation in worldwide collections of a major fungal pathogen
Thermal adaptation in worldwide collections of a major fungal pathogen Open
Adaptation to new climates poses a significant challenge for plant pathogens during range expansion, highlighting the importance of understanding their response to climate to accurately forecast future disease outbreaks. The wheat pathogen…
View article: Molecular epidemiology of Cercospora leaf spot on resistant and susceptible sugar beet hybrids
Molecular epidemiology of Cercospora leaf spot on resistant and susceptible sugar beet hybrids Open
Cercospora leaf spot (CLS), caused by Cercospora beticola , is a major foliar disease impacting sugar beet production worldwide. The development of new resistant sugar beet hybrids is a powerful tool to better manage the disease, but it is…
View article: A genome-wide association study identifies markers and candidate genes affecting tolerance to the wheat pathogen<i>Zymoseptoria tritici</i>
A genome-wide association study identifies markers and candidate genes affecting tolerance to the wheat pathogen<i>Zymoseptoria tritici</i> Open
Plants defend themselves against pathogens using either resistance, measured as the host’s ability to limit pathogen multiplication, or tolerance, measured as the host’s ability to reduce the negative effects of infection. Tolerance is a p…
View article: Cultivar-specific fungicide resistance emerges during a growing season in field populations of<i>Zymoseptoria tritici</i>
Cultivar-specific fungicide resistance emerges during a growing season in field populations of<i>Zymoseptoria tritici</i> Open
Zymoseptoria tritici causes the most damaging wheat disease in Europe, septoria tritici blotch (STB). In Europe, STB is controlled mainly by fungicides and fungicide resistance is frequently reported. While fungicide resistance is thought …
View article: A novel genome-wide association approach reveals wheat pathogen genes involved in host specialization
A novel genome-wide association approach reveals wheat pathogen genes involved in host specialization Open
Plant-pathogenic microbes, including the wheat fungal pathogen Zymoseptoria tritici, adapt to their host environment. In plants, genome-wide association studies (GWAS) have been extensively used to uncover the complexity of local adaptatio…
View article: Towards high throughput in-field detection and quantification of wheat foliar diseases with deep learning
Towards high throughput in-field detection and quantification of wheat foliar diseases with deep learning Open
1 Abstract Reliable, quantitative information on the presence and severity of crop diseases is critical for site-specific crop management and resistance breeding. Successful analysis of leaves under naturally variable lighting, presenting …
View article: SYMPATHIQUE: Image-based tracking of Symptoms and monitoring of Pathogenesis to decompose Quantitative disease resistance in the field
SYMPATHIQUE: Image-based tracking of Symptoms and monitoring of Pathogenesis to decompose Quantitative disease resistance in the field Open
Background. Quantitative disease resistance (QR) is a complex, dynamic trait that is most reliably quantified in field-grown crops. Traditional disease assessments offer limited potential to disentangle the contributions of different compo…
View article: GWAS reveals a rapidly evolving candidate avirulence effector in the Cercospora leaf spot pathogen
GWAS reveals a rapidly evolving candidate avirulence effector in the Cercospora leaf spot pathogen Open
The major resistance gene BvCR4 recently bred into sugar beet hybrids provides a high level of resistance to Cercospora leaf spot caused by the fungal pathogen Cercospora beticola . The occurrence of pathogen strains that overcome BvCR4 wa…
View article: Virulent strains of Zymoseptoria tritici suppress the host immune response and facilitate the success of avirulent strains in mixed infections
Virulent strains of Zymoseptoria tritici suppress the host immune response and facilitate the success of avirulent strains in mixed infections Open
Plants interact with a plethora of pathogenic microorganisms in nature. Pathogen-plant interaction experiments focus mainly on single-strain infections, typically ignoring the complexity of multi-strain infections even though mixed infecti…
View article: Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen
Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen Open
Microbial pathogens often harbor substantial functional diversity driven by structural genetic variation. Rapid adaptation from such standing variation threatens global food security and human health. Genome-wide association studies (GWAS)…
View article: Molecular epidemiology of Cercospora leaf spot on resistant and susceptible sugar beet hybrids
Molecular epidemiology of Cercospora leaf spot on resistant and susceptible sugar beet hybrids Open
Cercospora leaf spot (CLS), caused by Cercospora beticola , is a major foliar disease impacting sugar beet production worldwide. The development of new resistant sugar beet hybrids is a powerful tool to better manage the disease, but it is…
View article: Quantitative trait locus mapping of osmotic stress response in the fungal wheat pathogen <i>Zymoseptoria tritici</i>
Quantitative trait locus mapping of osmotic stress response in the fungal wheat pathogen <i>Zymoseptoria tritici</i> Open
Osmotic stress is a ubiquitous and potent stress for all living organisms, but few studies have investigated the genetic basis of salt tolerance in filamentous fungi. The main aim of this study was to identify regions of the genome associa…
View article: Recurrent chromosome destabilization through repeat-mediated rearrangements in a fungal pathogen
Recurrent chromosome destabilization through repeat-mediated rearrangements in a fungal pathogen Open
Genomic instability caused by chromosomal rearrangements has severe consequences for organismal fitness and progression of cancerous cell lines. The triggers of destabilized chromosomes remain poorly understood but likely co-locate with fr…
View article: Genome-wide association studies reveal a rapidly evolving candidate avirulence effector in the Cercospora leaf spot pathogen<i>Cercospora beticola</i>
Genome-wide association studies reveal a rapidly evolving candidate avirulence effector in the Cercospora leaf spot pathogen<i>Cercospora beticola</i> Open
Summary The major resistance gene BvCR4 recently bred into sugar beets provides a high level of resistance to Cercospora leaf spot caused by the fungal pathogen Cercospora beticola . The occurrence of pathogen strains virulent to BvCR4 was…
View article: A transcription factor and a phosphatase regulate temperature-dependent morphogenesis in the fungal plant pathogen Zymoseptoria tritici
A transcription factor and a phosphatase regulate temperature-dependent morphogenesis in the fungal plant pathogen Zymoseptoria tritici Open
Naturally fluctuating temperatures provide a constant environmental stress that requires adaptation. Some fungal pathogens respond to heat stress by producing new morphotypes that maximize their overall fitness. The fungal wheat pathogen Z…
View article: <i>Zymoseptoria tritici</i>suppresses the host immune response and facilitates the success of avirulent strains in mixed infections
<i>Zymoseptoria tritici</i>suppresses the host immune response and facilitates the success of avirulent strains in mixed infections Open
Summary Plants interact with a plethora of pathogenic microorganisms in nature. Pathogen-plant interaction experiments focus mainly on single-strain infections, typically ignoring the complexity of multi-strain infections even though mixed…
View article: A Global Assessment of the State of Plant Health
A Global Assessment of the State of Plant Health Open
The Global Plant Health Assessment (GPHA) is a collective, volunteer-based effort to assemble expert opinions on plant health and disease impacts on ecosystem services based on published scientific evidence. The GPHA considers a range of f…
View article: Combining high-resolution imaging, deep learning, and dynamic modelling to separate disease and senescence in wheat canopies
Combining high-resolution imaging, deep learning, and dynamic modelling to separate disease and senescence in wheat canopies Open
Maintenance of sufficient healthy green leaf area after anthesis is key to ensuring an adequate assimilate supply for grain filling. Tightly regulated age-related physiological senescence and various biotic and abiotic stressors drive over…