Thomas B. Nutman
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View article: A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling 4854
A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling 4854 Open
Description While inputs regulating CD4+ T helper cell (Th) differentiation are well-defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th-lineage identity remain unresolved. PI3K sign…
View article: Factors associated with low coverage in mass drug administration for schistosomiasis in mobile populations in Mali: a cross-sectional study
Factors associated with low coverage in mass drug administration for schistosomiasis in mobile populations in Mali: a cross-sectional study Open
These findings reveal notable disparities in MDA participation, influenced by mobility patterns, information access, and trust in health programs. Addressing these barriers requires context-specific approaches, such as improved communicati…
View article: Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination
Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination Open
The success of mass drug administration at reducing the prevalence of lymphatic filariasis in endemic areas has led to an increased need for highly sensitive and specific diagnostic assays. To be useful in post-elimination surveillance in …
View article: Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis
Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis Open
Background Subarachnoid neurocysticercosis (SANCC) is a condition manifested by chronic meningitis induced by infection with Taenia solium. We sought to determine if there is evidence of autoantibody production in SANCC and whether local p…
View article: Recombinant antigen-based lateral flow tests for the detection of Strongyloides stercoralis infection
Recombinant antigen-based lateral flow tests for the detection of Strongyloides stercoralis infection Open
Background Strongyloidiasis is a serious public health issue affecting millions of people worldwide particularly in tropical and subtropical regions. The laboratory diagnosis of strongyloidiasis is often serologically based, typically by e…
View article: Xenomonitoring as an epidemiological tool adjunct to post-stop surveillance of albendazole ivermectin mass drug distribution in the Bougouni -Yanfolila evaluation unit in the Sikasso, Mali in 2023
Xenomonitoring as an epidemiological tool adjunct to post-stop surveillance of albendazole ivermectin mass drug distribution in the Bougouni -Yanfolila evaluation unit in the Sikasso, Mali in 2023 Open
Introduction: Mali and Guinea share a border and are endemic to lymphatic filariasis (LF), however each country is at a distinct level in its LF elimination efforts. Mali is in the LF transmission assessment survey (TAS) phase, whereas Gui…
View article: A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4<sup>+</sup>T helper cell signaling, differentiation and epigenetic remodeling
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4<sup>+</sup>T helper cell signaling, differentiation and epigenetic remodeling Open
While inputs regulating CD4 + T helper cell (Th) differentiation are well-defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th-lineage identity remain unresolved. PI3K signaling is a …
View article: Immunologic Profiling of CSF in Subarachnoid Neurocysticercosis Reveals Specific Interleukin-10–Producing Cell Populations During Treatment
Immunologic Profiling of CSF in Subarachnoid Neurocysticercosis Reveals Specific Interleukin-10–Producing Cell Populations During Treatment Open
This profile of immune cell populations in the CSF provides a comprehensive blueprint of the local and systemic immunology associated with SANCC. The identification of IL-10-producing cells in the CSF and peripheral blood deepens our under…
View article: Brugia malayi filarial helminth-derived extracellular vesicles suppress antigen presenting cell function and antigen-specific CD4+ T cell responses
Brugia malayi filarial helminth-derived extracellular vesicles suppress antigen presenting cell function and antigen-specific CD4+ T cell responses Open
Introduction Live microfilariae (mf) and mf-derived extracellular vesicles (EVs) have been shown to modulate human antigen presenting cell (APC) function, most notably by suppressing the induction of IL-12 (and other pro-inflammatory cytok…
View article: Understanding the barriers and facilitators related to never treatment during mass drug administration among mobile and migrant populations in Mali: a qualitative exploratory study
Understanding the barriers and facilitators related to never treatment during mass drug administration among mobile and migrant populations in Mali: a qualitative exploratory study Open
Introduction Five of the neglected tropical diseases use a strategy of preventative chemotherapy distributed via mass drug administration (MDA) for all eligible people living in endemic areas. To be successful, high coverage must be sustai…
View article: Improved Nucleic Acid Amplification Test for the Diagnosis of Onchocerciasis and Its Use for Detection of Circulating Cell-free DNA
Improved Nucleic Acid Amplification Test for the Diagnosis of Onchocerciasis and Its Use for Detection of Circulating Cell-free DNA Open
Background The coendemicity of onchocerciasis with other filariae warrants a better diagnostic tool for elimination efforts that are highly sensitive and specific for use in surveillance and xenomonitoring. Methods Based on next-generation…
View article: Effect of Adding a Six-Week Course of Doxycycline to Intensive Hygiene-Based Care for Improving Lymphedema in a Rural Setting of Mali: A Double-Blind, Randomized Controlled 24-Month Trial
Effect of Adding a Six-Week Course of Doxycycline to Intensive Hygiene-Based Care for Improving Lymphedema in a Rural Setting of Mali: A Double-Blind, Randomized Controlled 24-Month Trial Open
Lymphedema (LE) is one the most disfiguring chronic manifestations of lymphatic filariasis. Its management relies primarily on limb hygiene and local care. A previous study in Ghana demonstrating a beneficial effect of doxycycline on LE le…
View article: Anthroponotic and Zoonotic Hookworm DNA in an Indigenous Community in Coastal Ecuador: Potential Cross-Transmission between Dogs and Humans
Anthroponotic and Zoonotic Hookworm DNA in an Indigenous Community in Coastal Ecuador: Potential Cross-Transmission between Dogs and Humans Open
Humans can be infected with anthroponotic (Ancylostoma duodenale and Necator americanus) and with zoonotic (Ancylostoma ceylanicum, A. caninum, A. braziliense, and Uncinaria stenocephala) hookworms from dogs. Anthroponotic species are usua…
View article: Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humans
Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humans Open
To unravel the heterogeneity and molecular signature of effector memory Th2 cells (Tem2), we analyzed 23 individuals' PBMCs of filaria-infected (Filaria+) and 24 healthy volunteers (Filaria-), with or without coincident house dust mite (HD…
View article: Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study
Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study Open
Background Numerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregu…
View article: Geographic Distribution of Human Infections with Zoonotic Ancylostoma ceylanicum and Anthropophilic Hookworms in Ecuador: A Retrospective Analysis of Archived Stool Samples
Geographic Distribution of Human Infections with Zoonotic Ancylostoma ceylanicum and Anthropophilic Hookworms in Ecuador: A Retrospective Analysis of Archived Stool Samples Open
Zoonotic human infections with Ancylostoma ceylanicum have recently been reported in the Americas. We used archived human stool samples to study the geographic distribution of human infections with A. ceylanicum and anthropophilic hookworm…
View article: Optimized strategy for real-time qPCR detection of Onchocerca volvulus DNA in pooled Simulium sp. blackfly vectors
Optimized strategy for real-time qPCR detection of Onchocerca volvulus DNA in pooled Simulium sp. blackfly vectors Open
Background Onchocerca volvulus is a filarial parasite that is a major cause of dermatitis and blindness in endemic regions primarily in sub-Saharan Africa. Widespread efforts to control the disease caused by O . volvulus infection (onchoce…
View article: Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery
Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery Open
Background Multisystem inflammatory syndrome (MIS) in children is considered to be a post-infectious complication of COVID-19. T-cell responses in children with this condition have not been well-studied. Methods We aimed to study the immun…
View article: Progress towards elimination of onchocerciasis transmission in Mali: A “pre-stop MDA” survey in 18 transmission zones
Progress towards elimination of onchocerciasis transmission in Mali: A “pre-stop MDA” survey in 18 transmission zones Open
Background Onchocerciasis control activities in Mali began in 1975 with vector larviciding carried out by the Onchocerciasis Control Programme (OCP), followed by the distribution of ivermectin from 1998 until the closure of the OCP in 2002…
View article: Improved NAAT assay for the diagnosis of onchocerciasis and its use for detection of circulating cell free DNA
Improved NAAT assay for the diagnosis of onchocerciasis and its use for detection of circulating cell free DNA Open
Mass drug administration (MDA) programs aimed at control and elimination of onchocerciasis relies on annual or semi-annual distribution of Ivermectin (IVM) that target the microfialarial (mf) stage of the parasite Onchocerca volvulus . The…
View article: Correction: Onchocerciasis: Target product profiles of in vitro diagnostics to support onchocerciasis elimination mapping and mass drug administration stopping decisions
Correction: Onchocerciasis: Target product profiles of in vitro diagnostics to support onchocerciasis elimination mapping and mass drug administration stopping decisions Open
[This corrects the article DOI: 10.1371/journal.pntd.0010682.].
View article: Case 17-2023: A 58-Year-Old Woman with Fatigue, Abdominal Bloating, and Eosinophilia
Case 17-2023: A 58-Year-Old Woman with Fatigue, Abdominal Bloating, and Eosinophilia Open
A 58-year-old woman presented with fatigue, abdominal bloating, and eosinophilia. Eight months earlier, she had fractured her tibia while traveling in the Democratic Republic of Congo. A diagnostic test was performed.
View article: Triplex ELISA for Assessing Durability of <i>Taenia solium</i> Seropositivity after Neurocysticercosis Cure
Triplex ELISA for Assessing Durability of <i>Taenia solium</i> Seropositivity after Neurocysticercosis Cure Open
Neurocysticercosis prevalence estimates often are based on serosurveys. However, assessments of Taenia solium seropositivity durability in patients with various neurocysticercosis types are lacking. We optimized a triplex serologic ELISA b…
View article: A Novel, Highly Sensitive Nucleic Acid Amplification Test Assay for the Diagnosis of Loiasis and its Use for Detection of Circulating Cell-Free DNA
A Novel, Highly Sensitive Nucleic Acid Amplification Test Assay for the Diagnosis of Loiasis and its Use for Detection of Circulating Cell-Free DNA Open
Mass drug administration programs targeting filarial infections depend on diagnostic tools that are sensitive and specific. The coendemicity of Loa loa with other filarial species often hampers the control programs. LL2634 was identified a…
View article: PI3Kδ shapes Th2 lineage restriction through coordination of IL-2 signaling, Foxo1 inactivation and epigenetic remodeling
PI3Kδ shapes Th2 lineage restriction through coordination of IL-2 signaling, Foxo1 inactivation and epigenetic remodeling Open
Activated PI3K-delta syndrome (APDS) is a primary immunodeficiency caused by heterozygous activating mutations in PI3Kδ, resulting in recurrent infections as well as allergic diseases. Given that APDS patients show an inability to clear re…
View article: Impact of short-term discontinuation of ivermectin-based chemoprevention on onchocerciasis transmission in endemic settings with long history of mass drug administration
Impact of short-term discontinuation of ivermectin-based chemoprevention on onchocerciasis transmission in endemic settings with long history of mass drug administration Open
Background The control of onchocerciasis currently relies on annual distribution of single dose ivermectin. Because ivermectin has minimal effects on the adult parasite, mass drug administration (MDA) campaigns against onchocerciasis requi…