Bruno Aouizerate
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View article: Evidence for the absence of a relationship between inflammation and cognition in a cohort of 1565 individuals with bipolar spectrum disorders: a Bayesian analysis of network
Evidence for the absence of a relationship between inflammation and cognition in a cohort of 1565 individuals with bipolar spectrum disorders: a Bayesian analysis of network Open
View article: High Psychological Impact of Covid‐19 on French Healthcare Workers: An Observational Cohort Study of PTSD, Depression and Burn‐Out
High Psychological Impact of Covid‐19 on French Healthcare Workers: An Observational Cohort Study of PTSD, Depression and Burn‐Out Open
Introduction The Covid‐19 outbreak hit the world forcing public institutions to rethink their core functioning. Healthcare workers (HCWs) were particularly at risk for negative mental health outcomes, given their direct exposure to many pa…
View article: Clinical and inflammatory markers associated with metabolic dysfunction-associated fatty liver disease in a cohort of individuals with chronic schizophrenia (FACE-SZ)
Clinical and inflammatory markers associated with metabolic dysfunction-associated fatty liver disease in a cohort of individuals with chronic schizophrenia (FACE-SZ) Open
Although not generalizable to all patients with schizophrenia, this study confirms the high prevalence of MAFLD in individuals with schizophrenia. Psychiatrists should promote healthy lifestyle changes, such as weight control, improved die…
View article: Substance use disorders in outpatients with bipolar disorder and pain complaints
Substance use disorders in outpatients with bipolar disorder and pain complaints Open
Our study highlights multiple associations in individuals with BD between the intensity of reported pain and history of lifetime AUD.
View article: Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity
Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity Open
View article: Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort
Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort Open
Migraine is common in BD, especially in younger individuals, females, and those with sleep disturbances or a history of trauma, who also experience a higher clinical burden. These overlapping factors highlight the need for an integrated tr…
View article: Prediction of relapse in a French cohort of outpatients with schizophrenia (FACE-SZ): Prediction, not association.
Prediction of relapse in a French cohort of outpatients with schizophrenia (FACE-SZ): Prediction, not association. Open
View article: How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project
How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project Open
View article: Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1 Open
View article: Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder
Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder Open
Importance Examining translatable mitochondrial blood-based biological markers to identify its association with metabolic diseases in bipolar disorder. Objective To test whether mitochondrial metabolites, mainly lactate, and cell-free circ…
View article: Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study
Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study Open
Background Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as …
View article: Predictors of medication adherence in a large 1-year prospective cohort of individuals with schizophrenia: insights from the multicentric FACE-SZ dataset
Predictors of medication adherence in a large 1-year prospective cohort of individuals with schizophrenia: insights from the multicentric FACE-SZ dataset Open
Schizophrenia is characterized by the most salient medication adherence problems among severe mental disorders, but limited prospective data are available to predict and improve adherence in this population. This investigation aims to iden…
View article: Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: Results from the FACE-BD cohort
Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: Results from the FACE-BD cohort Open
View article: Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1 Open
Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The ai…
View article: Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort
Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort Open
Previous studies set out profound cognitive impairments in subjects with treatment-resistant depression (TRD). However, little is known about the course of such alterations depending on levels of improvement in those patients followed long…
View article: Axo-axonic cells in neuropsychiatric disorders: a systematic review
Axo-axonic cells in neuropsychiatric disorders: a systematic review Open
Imbalance between excitation and inhibition in the cerebral cortex is one of the main theories in neuropsychiatric disorder pathophysiology. Cortical inhibition is finely regulated by a variety of highly specialized GABAergic interneuron t…
View article: Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise - Bipolar Disorder cohort
Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise - Bipolar Disorder cohort Open
View article: Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: results from the FACE-BD cohort
Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: results from the FACE-BD cohort Open
Bipolar disorders (BD) are characterized by cognitive impairment during the euthymic phase, to which treatments can contribute. The anticholinergic properties of medications, i.e., the ability of a treatment to inhibit cholinergic receptor…
View article: Substance use disorders in bipolar patients with a painful expression
Substance use disorders in bipolar patients with a painful expression Open
Introduction Bipolar Disorder (BD) is a common psychiatric disease. It has been demonstrated a long time ago that bipolar patients are more painful than the healthy subjects. Substance use disorder is a frequent comorbidity in BD, but also…
View article: EMDR for symptoms of depression, stress and burnout in health care workers exposed to COVID-19 (HARD): A study protocol for a trial within a cohort study
EMDR for symptoms of depression, stress and burnout in health care workers exposed to COVID-19 (HARD): A study protocol for a trial within a cohort study Open
Background: Stressful events during a pandemic are a major cause of serious health problems, such as burnout, depression and posttraumatic stress disorder (PTSD) among health care workers (HCWs). During three years, HCWs, on the fro…
View article: Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia
Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia Open
View article: Prefrontal slow oscillations in pathological anxiety
Prefrontal slow oscillations in pathological anxiety Open
View article: Effectiveness of Self-guided Tailored Implementation Strategies in Integrating and Embedding Internet-Based Cognitive Behavioral Therapy in Routine Mental Health Care: Results of a Multicenter Stepped-Wedge Cluster Randomized Trial
Effectiveness of Self-guided Tailored Implementation Strategies in Integrating and Embedding Internet-Based Cognitive Behavioral Therapy in Routine Mental Health Care: Results of a Multicenter Stepped-Wedge Cluster Randomized Trial Open
Background Internet-based cognitive behavioral therapy (iCBT) services for common mental health disorders have been found to be effective. There is a need for strategies that improve implementation in routine practice. One-size-fits-all st…
View article: Effectiveness of self-guided tailored implementation strategies in integrating and embedding Internet-based Cognitive Behavioural Therapy in routine mental health care. Results of the ImpleMentAll project. (Preprint)
Effectiveness of self-guided tailored implementation strategies in integrating and embedding Internet-based Cognitive Behavioural Therapy in routine mental health care. Results of the ImpleMentAll project. (Preprint) Open
BACKGROUND Internet-based Cognitive Behaviour Therapy (iCBT) services for common mental health disorders have been found to be effective. There is a need for effective strategies to improve implementation in routine practice. One-size-fit…
View article: Neuromodulation Treatments of Pathological Anxiety in Anxiety Disorders, Stressor-Related Disorders, and Major Depressive Disorder: A Dimensional Systematic Review and Meta-Analysis
Neuromodulation Treatments of Pathological Anxiety in Anxiety Disorders, Stressor-Related Disorders, and Major Depressive Disorder: A Dimensional Systematic Review and Meta-Analysis Open
Background Pathological anxiety is responsible for major functional impairments and resistance to conventional treatments in anxiety disorders (ADs), posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Focal neuromodu…
View article: Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort
Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort Open
We have identified five cytokines associated with MetS in SZ suggesting that patients with psychotic disorders and MetS are characterized by a specific "immuno-metabolic" profile. This may help to design tailored treatments for this subgro…
View article: Direct medical cost of bipolar disorder: Insights from the FACE-BD longitudinal cohort
Direct medical cost of bipolar disorder: Insights from the FACE-BD longitudinal cohort Open
View article: High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers
High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers Open
Background The relationship between antidepressant response and glial, inflammatory, and metabolic markers is poorly understood in depression. This study assessed the ability of biological markers to predict antidepressant response in majo…
View article: Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study Open
View article: Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders
Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders Open
Background Psychiatric comorbidities and suicide attempts are highly prevalent in Bipolar Disorders (BD). We examined the associations between childhood maltreatment, psychiatric comorbidities, and suicide attempts, in terms of lifetime pr…