Bruno Cadot
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View article: GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD
GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD Open
Duchenne muscular dystrophy (DMD) is a fatal disease caused by dystrophin deficiency, leading to degeneration of the entire musculature. To improve muscle pathophysiology and gene therapy for DMD, we investigated the potential of growth di…
View article: Early Endosome Disturbance and Endolysosomal Pathway Dysfunction in Duchenne Muscular Dystrophy
Early Endosome Disturbance and Endolysosomal Pathway Dysfunction in Duchenne Muscular Dystrophy Open
View article: Generation and Characterization of <i>Col6a1</i> knock-in mice: A Promising Pre-Clinical Model for Collagen VI-Related Dystrophies
Generation and Characterization of <i>Col6a1</i> knock-in mice: A Promising Pre-Clinical Model for Collagen VI-Related Dystrophies Open
Collagen VI Related Dystrophies (COL6-RD) are congenital muscle diseases, typically inherited as an autosomal dominant trait. A frequent type of mutation involves glycine substitutions in the triple helical domain of collagen VI alpha chai…
View article: Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy
Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy Open
Duchenne muscular dystrophy (DMD) is a lethal dystrophy characterized by the progressive loss of muscle fibers caused by mutations in DMD gene and absence of the dystrophin protein. While autophagy and lysosome biogenesis defects have been…
View article: Therapeutic approach based on GDF5 to counteract age-related muscle wasting Fundamental Myology Muscle function
Therapeutic approach based on GDF5 to counteract age-related muscle wasting Fundamental Myology Muscle function Open
International audience
View article: GDF5 as a rejuvenating treatment for age-related neuromuscular failure
GDF5 as a rejuvenating treatment for age-related neuromuscular failure Open
Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during ageing, which results in increased inability and death; however, no cure has been established thus far. Growth differentiation factor 5 (GDF5) has bee…
View article: Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 3 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Data from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Data from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
We investigated the role of histone deacetylase 4 (HDAC4) using RNA interference (RNAi) and knockout cells to specifically address its role in cell cycle progression in tumor and normal cells. Ablation of HDAC4 led to growth inhibition in …
View article: Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Table 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure Legends 1-4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 4 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 1 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
Supplementary Figure 2 from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
View article: Data from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells
Data from Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells Open
We investigated the role of histone deacetylase 4 (HDAC4) using RNA interference (RNAi) and knockout cells to specifically address its role in cell cycle progression in tumor and normal cells. Ablation of HDAC4 led to growth inhibition in …
View article: Author response: Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation
Author response: Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation Open
View article: Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations Open
View article: Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation Open
Excitation-contraction coupling requires a highly specialized membrane structure, the triad, composed of a plasma membrane invagination, the T-tubule, surrounded by two sarcoplasmic reticulum terminal cisternae. Although the precise mechan…
View article: Exploring the protective role of GDF5 against skeletal muscle disuse atrophy
Exploring the protective role of GDF5 against skeletal muscle disuse atrophy Open
International audience
View article: Development of versatile allele-specific siRNAs able to silence all the dominant dynamin 2 mutations
Development of versatile allele-specific siRNAs able to silence all the dominant dynamin 2 mutations Open
View article: IMPatienT: an Integrated web application to digitize, process and explore Multimodal PATIENt daTa
IMPatienT: an Integrated web application to digitize, process and explore Multimodal PATIENt daTa Open
Medical acts, such as imaging, lead to the production of several medical text report that describes the relevant findings. This induces multimodality in patient data by linking image data to free-text and consequently, multimodal data have…
View article: Reconstituting the Interaction Between Purified Nuclei and Microtubule Network
Reconstituting the Interaction Between Purified Nuclei and Microtubule Network Open
View article: L’Atlas du Muscle : une banque d’images de biopsies musculaires
L’Atlas du Muscle : une banque d’images de biopsies musculaires Open
L’analyse des biopsies musculaires constitue un outil essentiel dans le domaine de la recherche et pour le diagnostic. La biopsie musculaire est régulièrement utilisée dans le diagnostic et l’évaluation de nombreuses maladies neuromusculai…
View article: Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration
Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration Open
View article: Actin on and around the Nucleus
Actin on and around the Nucleus Open