Bruno Charbit
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View article: Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors
Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors Open
Autoantibodies against cytokines (c‐aAb) have been implicated in the pathophysiology of autoimmune diseases, and a variety of infections. In addition, several independent studies have detected elevated titers of c‐aAb in the circulation of…
View article: Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people Open
View article: Smoking changes adaptive immunity with persistent effects
Smoking changes adaptive immunity with persistent effects Open
View article: Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses
Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses Open
Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses is lacking. Here, we a…
View article: Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia
Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia Open
Summary Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and …
View article: Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks
Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks Open
View article: Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses Open
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis ( M. tb ) infection impacts host immune responses. We compared the induced immune response to TB antigen, B…
View article: Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity Open
View article: Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort
Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort Open
View article: Variability of Primary Sjögren's Syndrome Is Driven by Interferon‐α and Interferon‐α Blood Levels Are Associated With the Class II HLA–DQ Locus
Variability of Primary Sjögren's Syndrome Is Driven by Interferon‐α and Interferon‐α Blood Levels Are Associated With the Class II HLA–DQ Locus Open
Objective Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integr…
View article: Defective type I interferon immunity is associated with increasing COVID-19 severity
Defective type I interferon immunity is associated with increasing COVID-19 severity Open
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported that reduced blood type I interferon (IFN-I) in severe COVID-1…
View article: Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation Open
View article: Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus Open
The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections. Reports suggest that RhD-negative individuals are better protected against infectious diseases and have overall better health. However, potenti…
View article: Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
View article: Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency
Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency Open
Both innate and adaptive lymphocytes have critical roles in mucosal defense that contain commensal microbial communities and protect against pathogen invasion. Here we characterize mucosal immunity in patients with severe combined immunode…
View article: Additional file 5 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 5 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 5: Table S4. Description of the association between plasma protein levels, age, sex and blood-cell fractions.
View article: Additional file 3 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 3 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 3: Table S2. Proteins with analysis-specific significant genetic association.
View article: Additional file 1 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 1 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 1: Table S1. List of the 297 plasma proteins assayed.
View article: Additional file 4 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 4 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 4: Table S3. Summary of previous plasma pQTL study design.
View article: Additional file 6 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 6 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 6: Table S5. Description of the significant protein-environmental variable pairs and variable contribution the variability of the protein expression levels.
View article: Additional file 7 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
Additional file 7 of Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes Open
Additional file 7: Table S6. Annotations of cis and trans pQTLs.
View article: Enhanced TLR3 Responsiveness in Hepatitis C Virus Resistant Women From the Irish Anti-D Cohort
Enhanced TLR3 Responsiveness in Hepatitis C Virus Resistant Women From the Irish Anti-D Cohort Open
View article: Severe COVID-19 is associated with hyperactivation of the alternative complement pathway
Severe COVID-19 is associated with hyperactivation of the alternative complement pathway Open
View article: Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus Open
The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections. Reports suggest that RhD-negative individuals are better protected against infectious diseases and have overall better health. However, potenti…
View article: Type I interferon response and vascular alteration in chilblain‐like lesions during the COVID‐19 outbreak*
Type I interferon response and vascular alteration in chilblain‐like lesions during the COVID‐19 outbreak* Open
Our findings support an activation loop in the skin in CLL associated with endothelial alteration and immune infiltration of cytotoxic and type I IFN-polarized cells leading to clinical manifestations.
View article: Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection Open
View article: Safety of sitagliptin in treatment of hepatocellular carcinoma in chronic liver disease patients
Safety of sitagliptin in treatment of hepatocellular carcinoma in chronic liver disease patients Open
Background & Aims Systemic therapies for hepatocellular carcinoma (HCC) treatment have limited efficacy and poor safety. Dipeptidyl peptidase‐4 inhibitors were initially developed and approved as treatment for type 2 diabetes, yet oral adm…
View article: Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection Open
Immune checkpoint inhibitors for melanoma improve adaptive T cell immunity during COVID-19 without exacerbating inflammation.
View article: A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis
A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis Open
View article: A monocyte/dendritic cell molecular signature of SARS-CoV-2 related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis. de Cevins et al.
A monocyte/dendritic cell molecular signature of SARS-CoV-2 related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis. de Cevins et al. Open
SARS-CoV-2 infection in children is generally milder than in adults, yet a proportion of cases result in hyperinflammatory conditions often including myocarditis. To better understand these cases, we applied a multi-parametric approach to …