Bruno M. F. Gonçalves
YOU?
Author Swipe
View article: Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide Derivatives
Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide Derivatives Open
Background/Objectives: The search for new anticancer agents from natural sources remains a key strategy in drug discovery. This study aimed to synthesize and evaluate novel triazole derivatives of the diterpenic lactone andrographolide for…
View article: Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species
Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species Open
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkal…
View article: Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells
Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells Open
A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance.
View article: 1,2,3-Triazole-Substituted Andrographolide Derivatives as Anticancer Agents
1,2,3-Triazole-Substituted Andrographolide Derivatives as Anticancer Agents Open
View article: Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons Open
The demand for new biomass‐derived fine and commodity chemicals propels the discovery of new methodologies and synthons. Whereas furfural and 5‐hydroxymethylfurfural are cornerstones of sustainable chemistry, 3‐acetamido‐5‐acetyl furan (3A…
View article: Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons Open
The demand for new biomass‐derived fine and commodity chemicals propels the discovery of new methodologies and synthons. Whereas furfural and 5‐hydroxymethylfurfural are cornerstones of sustainable chemistry, 3‐acetamido‐5‐acetyl furan (3A…
View article: Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents
Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents Open
Arjunolic acid derivatives containing a pentameric A-ring were prepared. The biological activity on the viability of human cancer and non-tumor cell lines was evaluated as well as the molecular mechanism of action in PANC-1 cells for compo…
View article: Momordica balsamina: phytochemistry and pharmacological potential of a gifted species
Momordica balsamina: phytochemistry and pharmacological potential of a gifted species Open
View article: Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators
Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators Open
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotei…