Bruno P. Chumpitazi
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View article: Characterizing fermentable carbohydrate foods in the diets of children with abdominal pain-related disorders of gut-brain interaction and healthy children
Characterizing fermentable carbohydrate foods in the diets of children with abdominal pain-related disorders of gut-brain interaction and healthy children Open
Objectives Restricting dietary fermentable oligosaccharides, disaccharides, monosaccharides, and polyols ( FODMAPs ) can alleviate symptoms in children with disorders of gut-brain interaction ( DGBI ). Due to the restrictions of a low FODM…
View article: Protocol for a Randomized Controlled Trial to Determine if Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program
Protocol for a Randomized Controlled Trial to Determine if Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program Open
Background/Objectives: Disorders of gut–brain interaction (DGBI), characterized by chronic abdominal pain and significant disability, affect 15–20% of children and adults and continue into adulthood in ~60% of cases. Costs for adults reach…
View article: Characterizing Highly Fermentable Carbohydrate Foods in the Diets of Children with Disorders of Gut-Brain Interaction and Healthy Children
Characterizing Highly Fermentable Carbohydrate Foods in the Diets of Children with Disorders of Gut-Brain Interaction and Healthy Children Open
Objectives Restricting fermentable oligosaccharides, disaccharides, monosaccharides, and polyols ( FODMAPs ) intake can alleviate symptoms in children with gut-brain interaction disorders ( DGBI ). Due to the restrictive nature of the low …
View article: Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia
Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia Open
Background Avoidant/restrictive food intake disorder (ARFID) prevalence in children with gastroparesis (Gp) and/or functional dyspepsia (FD) is unknown. We aimed to identify ARFID prevalence and trajectory over 2 months in children with Gp…
View article: Genetic and acquired sucrase‐isomaltase deficiency: A clinical review
Genetic and acquired sucrase‐isomaltase deficiency: A clinical review Open
Genetic sucrase‐isomaltase deficiency (GSID) is an inherited deficiency in the ability to digest sucrose and potentially starch due to mutations in the sucrase‐isomaltase ( SI ) gene. Congenital sucrase‐isomaltase deficiency is historicall…
View article: Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis
Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis Open
Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with …
View article: A pilot genome‐wide association study meta‐analysis of gastroparesis
A pilot genome‐wide association study meta‐analysis of gastroparesis Open
Background Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction. Objective Genetic predisposition may play a role; however, investigation at the genome‐wide level has not been performed. …
View article: Factors Associated With Adherence to a Low Fermentable Carbohydrate Diet in Children With Functional Gastrointestinal Disorders
Factors Associated With Adherence to a Low Fermentable Carbohydrate Diet in Children With Functional Gastrointestinal Disorders Open
View article: Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis
Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis Open
IMD 0 and WLST were assessed for their clinical utility in assessing patients with symptoms of gastroparesis. Low IMD 0 is associated with less gastric retention and less heartburn. Volume of water consumed during WLST, while associated wi…
View article: Many pediatric patients with gastroparesis do not receive dietary education
Many pediatric patients with gastroparesis do not receive dietary education Open
View article: Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition
Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition Open
Background Patients with gastroparesis (Gp) may need enteral nutrition (EN) or exclusive parenteral nutrition (PN). Among patients with Gp, we aimed to (1) identify the frequency of EN and exclusive PN use and (2) explore characteristics o…
View article: Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial
Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial Open
View article: Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption
Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption Open
Human intestinal enzymes do not hydrolyze nondigestible carbohydrates (NDCs), and thus, they are not digested and absorbed in the small intestine. Instead, NDCs are partially to completely fermented by the intestinal microbiota. Select NDC…
View article: Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium
Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium Open
View article: Children with functional abdominal pain disorders successfully decrease FODMAP food intake on a low FODMAP diet with modest improvements in nutritional intake and diet quality
Children with functional abdominal pain disorders successfully decrease FODMAP food intake on a low FODMAP diet with modest improvements in nutritional intake and diet quality Open
Background We sought to determine how a low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet (LFD) affected high FODMAP food intake, nutrient intake, and diet quality in children with functional abdominal…
View article: Dietary Interventions for Gastroparesis: A Systematic Review
Dietary Interventions for Gastroparesis: A Systematic Review Open
View article: Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction
Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction Open
Dietary factors may play an important role in the generation of symptoms in children with disorders of gut-brain interaction (DGBIs). Although dietary modification may provide successful treatment, there is a relative paucity of controlled…
View article: Functional response to a microbial synbiotic in the gastrointestinal system of constipated children
Functional response to a microbial synbiotic in the gastrointestinal system of constipated children Open
Background Oral microbial therapy has been studied as an intervention for a range of gastrointestinal and immunological disorders. Though emerging research suggests microbial exposure may intimately affect the gastrointestinal system, moti…
View article: Peppermint oil effects on the gut microbiome in children with functional abdominal pain
Peppermint oil effects on the gut microbiome in children with functional abdominal pain Open
Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO …
View article: Gastrointestinal Dysmotility Is a Significant Feature in 2 Siblings With a Novel Inositol 1,4,5-Triphosphate Receptor 1 (ITPR1) Missense Variant
Gastrointestinal Dysmotility Is a Significant Feature in 2 Siblings With a Novel Inositol 1,4,5-Triphosphate Receptor 1 (ITPR1) Missense Variant Open
We present 2 siblings with a novel type 1 inositol 1,4,5-triphosphate receptor ( ITPR1 ) missense variant who exhibit gastrointestinal dysmotility (chronic constipation and gastroparesis). ITPR1 is expressed in the cerebellum and interstit…
View article: Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain
Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain Open
Aims Little is known regarding the pharmacokinetics and pharmacodynamics of menthol, the active ingredient in peppermint oil (PMO). Our aim was to investigate the pharmacokinetics of menthol at 3 dose levels in children and determine their…
View article: Gastrojejunal Enteral Tube Serving as a Small Bowel Bezoar Nidus
Gastrojejunal Enteral Tube Serving as a Small Bowel Bezoar Nidus Open
Gastrojejunal (GJ) tube placement is indicated in the management of gastric feeding-related intolerance. Though uncommon, GJ complications may occur. We present the case of a five-year-old male with congenital heart disease in which image-…
View article: Multisite Pain Is Highly Prevalent in Children with Functional Abdominal Pain Disorders and Is Associated with Increased Morbidity
Multisite Pain Is Highly Prevalent in Children with Functional Abdominal Pain Disorders and Is Associated with Increased Morbidity Open
View article: PedsQL™ Gastroparesis Symptoms Module Domain and Item Development
PedsQL™ Gastroparesis Symptoms Module Domain and Item Development Open
Objectives: Like adults, children suffer from gastroparesis; however, there are currently no validated instruments to determine the impact of gastroparesis in pediatric patients. The objective of this study was to develop the items and dom…
View article: Clinical Characterization of Pediatric Gastroparesis Using a Four‐hour Gastric Emptying Scintigraphy Standard
Clinical Characterization of Pediatric Gastroparesis Using a Four‐hour Gastric Emptying Scintigraphy Standard Open
Objectives: Four‐hour gastric emptying scintigraphy (GES) is the recommended method to identify both adult and childhood gastroparesis (GP). Previous pediatric studies have, however, not used this standard. We sought to determine the chara…
View article: Editorial: defining a microbial signature to predict non‐response to a low FODMAP diet—a step closer or is it? Authors' reply
Editorial: defining a microbial signature to predict non‐response to a low FODMAP diet—a step closer or is it? Authors' reply Open
LINKED CONTENT This article is linked to Chumpitazi et al and Halmos papers. To view these articles, visit https://doi.org/10.1111/apt.16204 and https://doi.org/10.1111/apt.16229
View article: Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features
Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features Open
View article: Outcomes of Non-anesthesiologist-Administered Propofol in Pediatric Gastroenterology Procedures
Outcomes of Non-anesthesiologist-Administered Propofol in Pediatric Gastroenterology Procedures Open
Background and Aims: Non-anesthesiologist-administered propofol (NAAP) has been found to have an acceptable safety profile in adult endoscopy, but its use remains controversial and pediatric data is limited. Our aim was to examine the safe…
View article: Meal-Induced Symptoms in Children with Dyspepsia–Relationships to Sex and the Presence of Gastroparesis
Meal-Induced Symptoms in Children with Dyspepsia–Relationships to Sex and the Presence of Gastroparesis Open
View article: Fructan‐sensitive children with irritable bowel syndrome have distinct gut microbiome signatures
Fructan‐sensitive children with irritable bowel syndrome have distinct gut microbiome signatures Open
Summary Background Dietary fructans may worsen gastrointestinal symptoms in children with irritable bowel syndrome (IBS). Aim To determine whether gut microbiome composition and function are associated with childhood IBS fructan‐induced sy…