Bruno Pillot
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View article: Role of heparin-induced HGF release in the acute phase of STEMI
Role of heparin-induced HGF release in the acute phase of STEMI Open
Introduction Reperfusion injury remains a major limitation in the management of ST-segment elevation myocardial infarction (STEMI). Despite numerous preclinical successes, cardioprotective strategies have largely failed in clinical transla…
View article: N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation
N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation Open
Background & Aims The gut-liver axis and hepatic ER-mitochondria miscommunication (at contact sites called MAMs) are involved in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the role …
View article: Author response: MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features
Author response: MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features Open
View article: MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features
MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features Open
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity, or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morph…
View article: Author response: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
Author response: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features Open
View article: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features Open
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morpho…
View article: Cold-Inducible RNA-Binding Protein in Cardiac Arrest and Renal Ischemia-Reperfusion Injury
Cold-Inducible RNA-Binding Protein in Cardiac Arrest and Renal Ischemia-Reperfusion Injury Open
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View article: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features Open
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morpho…
View article: Author response: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
Author response: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features Open
View article: MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features
MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features Open
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity, or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morph…
View article: Evaluation of general anesthesia protocols for a highly controlled cardiac ischemia-reperfusion model in mice
Evaluation of general anesthesia protocols for a highly controlled cardiac ischemia-reperfusion model in mice Open
Background The aim of our study was to test different anesthetic mixtures in order to identify the most suitable one for a surgical cardiac ischemia-reperfusion model in mice. Methods 1) Sixty four mice were submitted to one of the 6 combi…
View article: MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features Open
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morpho…
View article: #337 Renal 3D photoacoustic imaging and contrast-enhanced ultrasound to assess oxygenation and perfusion and to predict fibrosis after ischemia-reperfusion
#337 Renal 3D photoacoustic imaging and contrast-enhanced ultrasound to assess oxygenation and perfusion and to predict fibrosis after ischemia-reperfusion Open
Background and Aims Renal 3D photo-acoustic imaging (3D-PAI) and contrast-enhanced ultrasound (CEUS) are promising tools in mice models to assess repeatedly and non-invasively renal ischemia-reperfusion (RIR) consequences and damages, or t…
View article: Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase Open
Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage rec…
View article: Oxidation–reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium
Oxidation–reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium Open
View article: SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases Open
View article: Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions
Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions Open
Cyclosporine A (CsA) preconditioning is known to target mitochondrial permeability transition pore and protect renal function after ischemia reperfusion (IR). The upregulation of heat-shock protein 70 (Hsp70) expression after CsA injection…
View article: Oxidation-reduction imaging of myoglobin unveils two-phase oxidation in the reperfused myocardium
Oxidation-reduction imaging of myoglobin unveils two-phase oxidation in the reperfused myocardium Open
Myocardial infarction (MI) is a serious cardiovascular problem that causes myocardial injury due to blood flow obstruction to a specific myocardial area. Under ischemic-reperfusion settings, a burst of reactive oxygen species is generated,…
View article: SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases Open
The data supporting this article and other findings are available from the corresponding authors upon request and are reported in the enclosed Source data file.
View article: Mild Therapeutic Hypothermia Protects from Acute and Chronic Renal Ischemia-Reperfusion Injury in Mice by Mitigated Mitochondrial Dysfunction and Modulation of Local and Systemic Inflammation
Mild Therapeutic Hypothermia Protects from Acute and Chronic Renal Ischemia-Reperfusion Injury in Mice by Mitigated Mitochondrial Dysfunction and Modulation of Local and Systemic Inflammation Open
Renal ischemia-reperfusion (IR) injury can lead to acute kidney injury, increasing the risk of developing chronic kidney disease. We hypothesized that mild therapeutic hypothermia (mTH), 34 °C, applied during ischemia could protect the fun…
View article: Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia Open
View article: Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis
Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis Open
View article: Myocardial Ischemia-Reperfusion and Diabetes: Lessons Learned From Bedside to Bench
Myocardial Ischemia-Reperfusion and Diabetes: Lessons Learned From Bedside to Bench Open
In front of the failure to translate from bench to bedside cardioprotective drugs against myocardial ischemia-reperfusion, research scientists are currently revising their animal models. Owing to its growing incidence nowadays, type 2 diab…
View article: DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries
DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries Open
Mitochondrial dynamics is a possible modulator of myocardial ischemia/reperfusion injuries (IRI). We previously reported that mice partially deficient in the fusion protein OPA1 exhibited higher IRI. Therefore, we investigated whether defi…
View article: Mechanisms of protection of mild therapeutic hypothermia during renal ischaemia-reperfusion in mice
Mechanisms of protection of mild therapeutic hypothermia during renal ischaemia-reperfusion in mice Open
View article: P0536HYPOTHERMIA DURING RENAL ISCHEMIA-REPERFUSION IN MICE: A PROTECTIVE EFFECT ON RENAL AND MITOCHONDRIAL FUNCTIONS
P0536HYPOTHERMIA DURING RENAL ISCHEMIA-REPERFUSION IN MICE: A PROTECTIVE EFFECT ON RENAL AND MITOCHONDRIAL FUNCTIONS Open
Background and Aims Renal ischemia reperfusion (RIR) can induce mitochondrial stress triggering cell death and eventually leading to acute kidney injury (AKI). It has been suggested that mild hypothermia could be protective in RIR without …
View article: Acute Induction of Translocon-Mediated Ca2+ Leak Protects Cardiomyocytes Against Ischemia/Reperfusion Injury
Acute Induction of Translocon-Mediated Ca2+ Leak Protects Cardiomyocytes Against Ischemia/Reperfusion Injury Open
During myocardial infarction, dysregulation of Ca2+ homeostasis between the reticulum, mitochondria, and cytosol occurs in cardiomyocytes and leads to cell death. Ca2+ leak channels are thought to be key regulators of the reticular Ca2+ ho…
View article: A Dynamic Transcriptional Analysis Reveals IL-6 Axis as a Prominent Mediator of Surgical Acute Response in Non-ischemic Mouse Heart
A Dynamic Transcriptional Analysis Reveals IL-6 Axis as a Prominent Mediator of Surgical Acute Response in Non-ischemic Mouse Heart Open
This study suggests that a strong induction of the IL-6 axis occurs in sham animals over the first 24 h and leads to the induction of inflammation and tissues' homeostasis processes.
View article: 1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding Open
View article: Critical appraisal of STAT3 pattern in adult cardiomyocytes
Critical appraisal of STAT3 pattern in adult cardiomyocytes Open