Bárbara Oliveira
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View article: Light-microscopy-based connectomic reconstruction of mammalian brain tissue
Light-microscopy-based connectomic reconstruction of mammalian brain tissue Open
The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connec…
View article: In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution
In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution Open
Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis. This study evaluates the comparative potential of CaHA in conventional saline dil…
View article: Erectile Dysfunction In Young People With Type I Diabetes: Prevalence, Comorbidities And Therapeutic Response
Erectile Dysfunction In Young People With Type I Diabetes: Prevalence, Comorbidities And Therapeutic Response Open
Erectile dysfunction (ED) is a disorder defined as the consistent or recurrent inability to achieve and or maintain a penile erection sufficient for sexual satisfaction. ED occurs on average 10-15 years earlier in men with diabetes and is …
View article: Characterization of individuals achieving type 2 diabetes remission in real-world settings: bridging clinical evidence and patient experiences
Characterization of individuals achieving type 2 diabetes remission in real-world settings: bridging clinical evidence and patient experiences Open
The objectives of the study were to (1) describe characteristics and lifestyle factors of individuals who have achieved type 2 diabetes (T2D) remission (sub-diabetes glucose levels without glucose-lowering medications for ≥3 months) throug…
View article: A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites Open
β-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously undescribed BHB secondary metabolic pathw…
View article: A secondary β-hydroxybutyrate metabolic pathway linked to energy balance
A secondary β-hydroxybutyrate metabolic pathway linked to energy balance Open
Summary β-hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve interconversion of BHB and primary energy intermediates. Here we show that CNDP2 controls a previously undescribed secondary …
View article: Light-microscopy based dense connectomic reconstruction of mammalian brain tissue
Light-microscopy based dense connectomic reconstruction of mammalian brain tissue Open
The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connec…
View article: Development and Implementation of a Nutritional Education Program Aimed at Improving the Integration Process of Young Orphan Refugees Newly Arrived in Portugal
Development and Implementation of a Nutritional Education Program Aimed at Improving the Integration Process of Young Orphan Refugees Newly Arrived in Portugal Open
(1) Background: Refugees are a population group at imminent risk of death, being forced to migrate to countries with different cultures. Many of the refugees are at great risk of malnutrition, especially adolescent orphans. The aim of the …
View article: Function-as-a-Service for the Cloud-to-Thing Continuum: A Systematic Mapping Study
Function-as-a-Service for the Cloud-to-Thing Continuum: A Systematic Mapping Study Open
Until recently, Internet of Things applications were mainly seen as a means to gather sensor data for further processing in the Cloud. Nowadays, with the advent of Edge and Fog Computing, digital services are dragged closer to the physical…
View article: CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories Open
Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsuff…
View article: Characterization of Coelomic Fluid Cell Types in the Starfish Marthasterias glacialis Using a Flow Cytometry/Imaging Combined Approach
Characterization of Coelomic Fluid Cell Types in the Starfish Marthasterias glacialis Using a Flow Cytometry/Imaging Combined Approach Open
Coelomocytes is the generic name for a collection of cellular morphotypes, present in many coelomate animals, and highly variable among echinoderm classes. The roles attributed to the major types of these free circulating cells present in …
View article: <i>CHD8</i> haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defects
<i>CHD8</i> haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defects Open
Chromodomain helicase DNA-binding 8 ( CHD8 ) is one of the most frequently mutated genes causative of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly and hence implicates cortical abnormalities …
View article: A combined characterization of coelomic fluid cell types in the spiny starfish<i>Marthasterias glacialis</i>– inputs from flow cytometry and imaging
A combined characterization of coelomic fluid cell types in the spiny starfish<i>Marthasterias glacialis</i>– inputs from flow cytometry and imaging Open
Coelomocytes is a generic name for a collection of cellular morphotypes, present in many coelomate animals, that has been reported as highly variable across echinoderm classes. The roles attributed to the major types of the free circulatin…
View article: Comparative study of strategies to prevent esophageal and periesophageal injury during atrial fibrillation ablation
Comparative study of strategies to prevent esophageal and periesophageal injury during atrial fibrillation ablation Open
We thank Dr Shah and colleagues for their interest, analysis of the presented data and comments related to our paper1. Circumferential PV isolation using 8mm tip catheter is still currently used in our institution for some patients due to …
View article: Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health Open
In the present thesis, the synergetic interaction between the nervous and immune
\nsystems and the potential pathological outcomes mediated by autoimmune processes
\ntargeting the brain was addressed, with a particular focus on autoantibod…
View article: Sexual dimorphism of AMBRA1-related autistic features in human and mouse
Sexual dimorphism of AMBRA1-related autistic features in human and mouse Open
Ambra1 is linked to autophagy and neurodevelopment. Heterozygous Ambra1 deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen in female mice only, combined with stronger Ambra1 …
View article: All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class
All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class Open
Autoantibodies of the IgG class against N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators. Recent work on together over 5000 individuals challenged this exclus…