Bruno V. Rego
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View article: A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare
A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare Open
The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simu…
View article: A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare
A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare Open
The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simu…
View article: Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model
Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model Open
In pursuit of a suitable scaffold material for cardiac valve tissue engineering applications, an acellular, electrospun, biodegradable polyester carbonate urethane urea (PECUU) scaffold was evaluated as a pulmonary valve leaflet replacemen…
View article: A Fast, Robust Method for Quantitative Assessment of Collagen Fibril Architecture from Transmission Electron Micrographs
A Fast, Robust Method for Quantitative Assessment of Collagen Fibril Architecture from Transmission Electron Micrographs Open
Collagen is the most abundant protein in mammals; it exhibits a hierarchical organization and provides structural support to a wide range of soft tissues, including blood vessels. The architecture of collagen fibrils dictates vascular stif…
View article: Effects of Age, Sex, and Extracellular Matrix Integrity on Aortic Dilatation and Rupture in a Mouse Model of Marfan Syndrome
Effects of Age, Sex, and Extracellular Matrix Integrity on Aortic Dilatation and Rupture in a Mouse Model of Marfan Syndrome Open
BACKGROUND: Transmural failure of the aorta is responsible for substantial morbidity and mortality; it occurs when mechanical stress exceeds strength. The aortic root and ascending aorta are susceptible to dissection and rupture in Marfan …
View article: A fast, robust method for quantitative assessment of collagen fibril architecture from transmission electron micrographs
A fast, robust method for quantitative assessment of collagen fibril architecture from transmission electron micrographs Open
Collagen is the most abundant protein in mammals; it exhibits a hierarchical organization and provides structural support to a wide range of soft tissues, including blood vessels. The architecture of collagen fibrils dictates vascular stif…
View article: In vivo assessment of mitral valve leaflet remodelling following myocardial infarction
In vivo assessment of mitral valve leaflet remodelling following myocardial infarction Open
View article: Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms
Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms Open
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta that can lead to life-threatening dissection or rupture. In vivo assessments of TAA progression are largely limited to measurements of aneurysm size and growth rate. The…
View article: Compensatory aortic remodeling in Marfan syndrome protects against sexually dimorphic rupture during a BAPN challenge
Compensatory aortic remodeling in Marfan syndrome protects against sexually dimorphic rupture during a BAPN challenge Open
Transmural rupture of the aorta is responsible for significant morbidity and mortality; it occurs when wall stress exceeds local wall strength. Amongst other conditions, the aortic root and ascending aorta become vulnerable to dissection a…
View article: Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms
Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms Open
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta resulting from compromised wall composition, structure, and function, which can lead to life-threatening dissection or rupture. Several genetic mutations and predisposin…
View article: Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator–regression neural network
Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator–regression neural network Open
Aortic dissection progresses mainly via delamination of the medial layer of the wall. Notwithstanding the complexity of this process, insight has been gleaned by studying in vitro and in silico the progression of dissection driven by quasi…
View article: Patient-Specific Quantification of Normal and Bicuspid Aortic Valve Leaflet Deformations from Clinically Derived Images
Patient-Specific Quantification of Normal and Bicuspid Aortic Valve Leaflet Deformations from Clinically Derived Images Open
View article: Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions
Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions Open
Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for significant morbidity and mortality. Advances in medical genetics and imaging have improved diagnosis and thus enabled earlier prophylactic surgical inte…
View article: Cover Image
Cover Image Open
The cover image is based on the Special Issue Article Uncertainty quantification in subject-specific estimation of local vessel mechanical properties by Bruno V. Rego et al., https://doi.org/10.1002/cnm.3535.
View article: Uncertainty quantification in subject‐specific estimation of local vessel mechanical properties
Uncertainty quantification in subject‐specific estimation of local vessel mechanical properties Open
Quantitative estimation of local mechanical properties remains critically important in the ongoing effort to elucidate how blood vessels establish, maintain, or lose mechanical homeostasis. Recent advances based on panoramic digital image …
View article: Simulating progressive intramural damage leading to aortic dissection using an operator-regression neural network
Simulating progressive intramural damage leading to aortic dissection using an operator-regression neural network Open
Aortic dissection progresses via delamination of the medial layer of the wall. Notwithstanding the complexity of this process, insight has been gleaned by studying in vitro and in silico the progression of dissection driven by quasi-static…
View article: Uncertainty quantification in subject-specific estimation of local vessel mechanical properties
Uncertainty quantification in subject-specific estimation of local vessel mechanical properties Open
Quantitative estimation of local mechanical properties remains critically important in the ongoing effort to elucidate how blood vessels establish, maintain, or lose mechanical homeostasis. Recent advances based on panoramic digital image …
View article: Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement
Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement Open
View article: Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains Open
View article: Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation
Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation Open
Objective: Ischemic mitral regurgitation (IMR) often develops after an ischemic event, which results in distortion of the valvulo-ventricular complex and incomplete mitral valve (MV) leaflet coaptation. After left ventricular ischemic even…
View article: Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling
Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling Open
Ischaemic mitral regurgitation (IMR), a frequent complication following myocardial infarction (MI), leads to higher mortality and poor clinical prognosis if untreated. Accumulating evidence suggests that mitral valve (MV) leaflets actively…
View article: What is the Remodeling Potential of the Native Heart Valve?
What is the Remodeling Potential of the Native Heart Valve? Open
Objective: Regenerative therapies directed at the restoration of heart valve function rely on an understanding on how native heart valve structures remodel and possibly regenerate. However, we know very little on how the native heart valve…
View article: Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling
Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling Open
Aims Ischemic mitral regurgitation is frequently observed following myocardial infarction and is associated with higher mortality and poor clinical prognosis if left untreated. Accumulating evidence suggests that mitral valve leaflets acti…
View article: Remodeling of the mitral valve : an integrated approach for predicting long-term outcomes in disease and repair
Remodeling of the mitral valve : an integrated approach for predicting long-term outcomes in disease and repair Open
Mitral regurgitation (MR) is the most prevalent valvular heart disease, afflicting 2.5% of the western-world population, and is becoming the next cardiac epidemic. MR is characterized by incomplete closure of the mitral valve (MV) caused b…
View article: On the Simulation of Mitral Valve Function in Health, Disease, and Treatment
On the Simulation of Mitral Valve Function in Health, Disease, and Treatment Open
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve (AV), the MV is an intimately coupled, fully fu…
View article: Cover Image
Cover Image Open
The cover image is based on the Research Article A noninvasive method for the determination of in vivo mitral valve leaflet strains by Bruno V. Rego et al., https://doi.org/10.1002/cnm.3142.
View article: Development of a Functionally Equivalent Model of the Mitral Valve Chordae Tendineae Through Topology Optimization
Development of a Functionally Equivalent Model of the Mitral Valve Chordae Tendineae Through Topology Optimization Open
View article: On the need for multi‐scale geometric modelling of the mitral heart valve
On the need for multi‐scale geometric modelling of the mitral heart valve Open
Mitral valve regurgitation (MVR) can cause serious complications like heart failure stroke, and in severe cases death. MVR occurs when blood leaks back to the left atrium during ventricular contraction due to the incomplete closure of the …
View article: Mitral valve leaflet remodelling during pregnancy: insights into cell-mediated recovery of tissue homeostasis
Mitral valve leaflet remodelling during pregnancy: insights into cell-mediated recovery of tissue homeostasis Open
Little is known about how valvular tissues grow and remodel in response to altered loading. In this work, we used the pregnancy state to represent a non-pathological cardiac volume overload that distends the mitral valve (MV), using both e…