Bruno Zatt
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View article: Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration
Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration Open
INTRODUCTION Current literature presents conflicting results regarding the impact of neuroinflammation on Alzheimer's disease (AD)‐related neurodegeneration. While some studies suggest that neuroinflammation potentiates neurodegeneration, …
View article: Enhancing Video Quality Using a Multi-Domain Spatio-Temporal Deformable Fusion Approach
Enhancing Video Quality Using a Multi-Domain Spatio-Temporal Deformable Fusion Approach Open
Video compression is essential for efficient data management but often introduces artifacts that degrade visual quality. This work presents the Multi-Domain Spatio-Temporal Deformable Fusion (MD-STDF) architecture, which employs a multi-do…
View article: Evaluation of Tile-based Parallelism in VVC Encoders for 360-degree Videos
Evaluation of Tile-based Parallelism in VVC Encoders for 360-degree Videos Open
This work evaluates the parallelism potential and the coding efficiency of Tile-enabled encoding of 360-degree videos for the Versatile Video Coding (VVC) standard. Six 4K conventional videos and eight 360-degree videos were tested with va…
View article: Universal tau PET scale (Uniτ) – The HEAD Study
Universal tau PET scale (Uniτ) – The HEAD Study Open
Background The HEAD study aims to collect a large dataset of multiple tau‐PET tracers to provide robust anchor values for tau‐PET harmonization. Here, we tested the hypothesis that anchoring two tau tracer uptake values using head‐to‐head …
View article: Universal tau PET scale (Uniτ) – The HEAD Study
Universal tau PET scale (Uniτ) – The HEAD Study Open
Background The HEAD study aims to collect a large dataset of multiple tau‐PET tracers to provide robust anchor values for tau‐PET harmonization. Here, we tested the hypothesis that anchoring two tau tracer uptake values using head‐to‐head …
View article: ZNF653 transcription factor activity is associated with FDG‐PET changes in AD brain‐vulnerable regions
ZNF653 transcription factor activity is associated with FDG‐PET changes in AD brain‐vulnerable regions Open
Background Positron emission tomography (PET) imaging greatly impacted Alzheimer’s disease (AD) research and diagnosis. which makes predicting PET brain imaging alterations using blood data is of high interest. Additionally, integrating PE…
View article: Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study
Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study Open
Background The HEAD study focuses on collecting an extensive dataset from various tau‐PET tracers, aiming to establish robust anchor values, which are essential for harmonizing tau‐PET measurements. Here, we aim to showcase the capability …
View article: Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study
Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study Open
Background The HEAD study focuses on collecting an extensive dataset from various tau‐PET tracers, aiming to establish robust anchor values, which are essential for harmonizing tau‐PET measurements. Here, we aim to showcase the capability …
View article: Fast ISP Mode Decision for the Versatile Video Coding Intra Prediction Using Machine Learning
Fast ISP Mode Decision for the Versatile Video Coding Intra Prediction Using Machine Learning Open
The Versatile Video Coding (VVC) standard achieves high compression rates by introducing new encoding tools, such as the Intra Subpartition Prediction (ISP). However, the ISP increases the computational effort necessary to perform the mode…
View article: Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease
Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease Open
INTRODUCTION Brain glucose hypometabolism, indexed by the fluorodeoxyglucose positron emission tomography ([ 18 F]FDG‐PET) imaging, is a metabolic signature of Alzheimer's disease (AD). However, the underlying biological pathways involved …
View article: Employing transfer learning to optimize deep learning models for Alzheimer’s disease classification using two tau PET tracers
Employing transfer learning to optimize deep learning models for Alzheimer’s disease classification using two tau PET tracers Open
Background Deep learning models, particularly convolutional neural networks (CNNs), have shown promise in Alzheimer’s disease (AD) classification using tau PET data. However, limited sample sizes and unharmonized tau tracers present challe…
View article: SBCCI 2022
SBCCI 2022 Open
The Symposium on ICs and Systems Design (SBCCI) is an international forum dedicated to ICs and systems design, test, and EDA, held annually in Brazil. Over the past four decades, SBCCI has established itself as an important international f…
View article: Efficient Dedicated Hardware Design System for the VVC Low-Frequency Non-Separable Transform
Efficient Dedicated Hardware Design System for the VVC Low-Frequency Non-Separable Transform Open
This paper proposes a dedicated hardware architecture for the Low-Frequency Non-Separable Transform (LFNST) of the Versatile Video Coding (H.266/VVC) standard. The VVC defines two stages of transformation, where the first stage uses tradit…
View article: VVC Decoder Intra Prediction Using Approximate Storage: an Error Resilience Evaluation
VVC Decoder Intra Prediction Using Approximate Storage: an Error Resilience Evaluation Open
This paper presents an error resilience evaluation of the intra prediction step in Versatile Video Coding (VVC) decoders when approximate storage is employed in the Reference Line Buffer (RLB). We present an error injection framework to si…
View article: Guest Editors’ Introduction: SBCCI 2021
Guest Editors’ Introduction: SBCCI 2021 Open
The Symposium on ICs and Systems Design (SBCCI) is an international forum dedicated to ICs and systems design, test and EDA, held annually in Brazil. Over the past four decades, SBCCI has established itself as an important international fo…
View article: Serine/threonine kinase activity associates with brain glucose metabolism changes in Alzheimer’s Disease
Serine/threonine kinase activity associates with brain glucose metabolism changes in Alzheimer’s Disease Open
Background Positron emission tomography (PET) imaging has greatly improved the diagnosis and monitoring of Alzheimer’s disease (AD). The recently developed neuroinformatic field is expanding analytical and computational strategies to study…
View article: Ultra-High Definition AV1 FME Interpolation Architectures Exploring Approximate Computing
Ultra-High Definition AV1 FME Interpolation Architectures Exploring Approximate Computing Open
Modern video encoders like the AOMedia Video 1 (AV1) implement several complex tools to allow the required high level of compression efficiency. The Fractional Motion Estimation (FME) is one of these complex tools, and AV1 FME defines 42 d…
View article: Improving Content-Aware Video Streaming in Congested Networks with In-Network Computing
Improving Content-Aware Video Streaming in Congested Networks with In-Network Computing Open
Network congestion and packet loss pose an ever-increasing challenge to video streaming. Despite the research efforts toward making video encoding schemes resilient to lossy network conditions, forwarding devices have not considered monito…
View article: Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology
Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology Open
Background Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathological features in cogni…
View article: Soluble Amyloid-Beta Isoforms Predict Downstream Alzheimer’s Disease Pathology
Soluble Amyloid-Beta Isoforms Predict Downstream Alzheimer’s Disease Pathology Open
Background: Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer's disease (AD). However, whether Aβ levels can predict downstream AD pathological features in cogn…
View article: Exploring ERP Distortions to Reduce the Encoding Time of 360 Videos
Exploring ERP Distortions to Reduce the Encoding Time of 360 Videos Open
The encoding of 360 videos presents many challenges. These videos require a planar projection stage before encoding, and there are no studies on how projection interferes with the encoder decisions. Also, due to the increased resolution, e…
View article: Guest Editors' Words
Guest Editors' Words Open
This Special Issues brings ten invited papers, from the experts of the field across the globe, focusing on different aspects of computing systems design and techniques to cope with the increasing level of complexity and specialization in m…
View article: A Terabit Hybrid FPGA-ASIC Platform for Switch Virtualization
A Terabit Hybrid FPGA-ASIC Platform for Switch Virtualization Open
The roll-out of technologies like 5G and the need for multi-terabit bandwidth in backbone networks requires networking companies to make significant investments to keep up with growing service demands. For lower capital expenditure and fas…
View article: Energy-Efficient NoC-Based Systems for Real-Time Multimedia Applications using Approximate Computing
Energy-Efficient NoC-Based Systems for Real-Time Multimedia Applications using Approximate Computing Open
This work presents an energy-efficient NoC-based system for real-time multimedia applications employing approximate computing. The proposed video processing system, called SApp-NoC, is efficient in both energy and quality (QoS), employing …
View article: AV1 and VVC Video Codecs: Overview on Complexity Reduction and Hardware Design
AV1 and VVC Video Codecs: Overview on Complexity Reduction and Hardware Design Open
This article presents an extensive review of the state-of-the-art system-level solutions featuring complexity reduction and/or dedicated hardware designs for the AV1 and VVC video coding formats. These formats introduced several novel codi…
View article: Hardware Implementation for the HEVC Fractional Motion Estimation Targeting Real-Time and Low-Energy
Hardware Implementation for the HEVC Fractional Motion Estimation Targeting Real-Time and Low-Energy Open
This paper presents an energy-aware and high-throughput hardware design for the Fractional Motion Estimation (FME) compliant with the High Efficiency Video Coding (HEVC) standard. An extensive software evaluation was performed to guide the…
View article: Low-Cost and High-Throughput Hardware Design for the HEVC 16x16 2-D DCT Transform
Low-Cost and High-Throughput Hardware Design for the HEVC 16x16 2-D DCT Transform Open
This article presents the hardware design of the 16x16 2-D DCT used in the new video coding standard, the HEVC – High Efficiency Video Coding. The transforms stage is one of the innovations proposed by HEVC, since a variable size transform…
View article: Memory-aware Workload Balancing Technique based on Decision Trees for Parallel HEVC Video Coding
Memory-aware Workload Balancing Technique based on Decision Trees for Parallel HEVC Video Coding Open
Video coding applications demand high computational effort to achieve high compression rates at a low perceptual quality expense. In order to reach acceptable encoding time for such applications, modern video coding standards have been em-…