Bryan D. Fleming
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View article: A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike Open
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobo…
View article: A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike Open
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobo…
View article: Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update
Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update Open
Hepatocellular carcinoma (HCC) accounts for most liver cancers and represents one of the deadliest cancers in the world. Despite the global demand for liver cancer treatments, there remain few options available. The U.S. Food and Drug Admi…
View article: Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention
Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention Open
Background and Aims Treatment of hepatocellular carcinomas using our glypican‐3 (GPC3)‐targeting human nanobody (HN3) immunotoxins causes potent tumor regression by blocking protein synthesis and down‐regulating the Wnt signaling pathway. …
View article: Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks
Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks Open
Background Shark new antigen receptor variable domain (VNAR) antibodies can bind restricted epitopes that may be inaccessible to conventional antibodies. Methods Here, we developed a library construction method based on polymerase chain re…
View article: Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer
Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer Open
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, yet no effective therapeutics exist. This review provides an overview of the recent development of recombinant immunotoxins for the treatment of glypican-3 (GP…
View article: The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling
The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling Open
Macrophages readily change their phenotype in response to exogenous stimuli. In this work, macrophages were stimulated under a variety of experimental conditions, and phenotypic alterations were correlated with changes in gene expression. …