Bryan Faust YOU? Author Swipe

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Engineered odorant receptors illuminate the basis of odour discrimination Open

Claire A. de March, Ning Ma, Christian B. Billesbølle, Jeevan Tewari, Claudia Llinás del Torrent , et al. · 2024

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2024

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Author response: Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2024

Author response: Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2024

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2024

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Engineered odorant receptors illuminate structural principles of odor discrimination Open

Claire A. de March, Ning Ma, Christian B. Billesbølle, Jeevan Tewari, Claudia Llinás del Torrent , et al. · 2023

A central challenge in olfaction is understanding how the olfactory system detects and distinguishes odorants with diverse physicochemical properties and molecular configurations. Vertebrate animals perceive odors via G protein-coupled odo…

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2023

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2023

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase Open

Roberto Efraín Díaz, Andrew K. Ecker, G.J. Correy, Pooja Asthana, I.D. Young , et al. · 2023

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, A…

Structural basis of odorant recognition by a human odorant receptor Open

Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari , et al. · 2023

Structural basis of odorant recognition by a human odorant receptor Open

Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari , et al. · 2022

Our sense of smell enables us to navigate a vast space of chemically diverse odor molecules. This task is accomplished by the combinatorial activation of approximately 400 olfactory G protein-coupled receptors (GPCRs) encoded in the human …

Autoantibody mimicry of hormone action at the thyrotropin receptor Open

Bryan Faust, Christian B. Billesbølle, Carl‐Mikael Suomivuori, Isha Singh, Kaihua Zhang , et al. · 2022

Autoantibody and hormone activation of the thyrotropin G protein-coupled receptor Open

Bryan Faust, Isha Singh, Kaihua Zhang, Nick Hoppe, Antônio F. M. Pinto , et al. · 2022

Thyroid hormones are vital to growth and metabolism. Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). Autoantibodies that activate the TSHR pathologically increase thyroid hormone…

Selective G protein signaling driven by substance P–neurokinin receptor dynamics Open

J.A. Harris, Bryan Faust, Arisbel B. Gondin, Marc A. Dämgen, Carl‐Mikael Suomivuori , et al. · 2021

MD data for "Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics" Open

J.A. Harris, Bryan Faust, Arisbel B. Gondin, Marc A. Dämgen, Carl‐Mikael Suomivuori , et al. · 2021

Molecular dynamics (MD) data for "Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics" (Harris et al., Nature Chemical Biology (2021), DOI: 10.1038/s41589-021-00890-8, URL: https://www.natur…

MD data for "Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics" Open

J.A. Harris, Bryan Faust, Arisbel B. Gondin, Marc A. Dämgen, Carl‐Mikael Suomivuori , et al. · 2021

Molecular dynamics (MD) data for "Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics" (Harris et al., Nature Chemical Biology (2021), DOI: 10.1038/s41589-021-00890-8, URL: https://www.natur…

Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics Open

J.A. Harris, Bryan Faust, Arisbel B. Gondin, Marc A. Dämgen, Carl‐Mikael Suomivuori , et al. · 2021

The neuropeptide Substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via G q and G s proteins. Neurokinin A also activates NK1R, but leads to selective G q signaling. How two stim…

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia Open

Daniel Asarnow, Bei Wang, Wen-Hsin Sandy Lee, Yuanyu Hu, Ching-Wen Huang , et al. · 2021

Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe Open

Kristyn Hayashi, Kenton L. Longenecker, Yiliang Liu, Bryan Faust, Aditi Prashar , et al. · 2021

Data for EMSL Project 51817 from May 2021 Open

Aashish Manglik, Ishan Deshpande, Nicholas Hoppe, Bryan Faust, Christian Billesboelle · 2021

Data for EMSL Project 51817 from May 2021 Open

Aashish Manglik, Ishan Deshpande, Nicholas Hoppe, Bryan Faust, Christian Billesboelle · 2021

Data for EMSL Project 51817 from May 2021 Open

Aashish Manglik, Ishan Deshpande, Nicholas Hoppe, Bryan Faust, Christian Billesboelle · 2021

Data for EMSL Project 51817 from May 2021 Open

Aashish Manglik, Ishan Deshpande, Nicholas Hoppe, Bryan Faust, Christian Billesboelle · 2021

Data for EMSL Project 51817 from May 2021 Open

Aashish Manglik, Ishan Deshpande, Nicholas Hoppe, Bryan Faust, Christian Billesboelle · 2021

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike Open

Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica V. Rezelj , et al. · 2020

Nanobodies that neutralize Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intra…

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 Open

Colton J. Bracken, Shion A. Lim, Paige Solomon, Nicholas J. Rettko, Duy Nguyen , et al. · 2020

Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic human variable heavy (VH) domains toward neutralizing epitopes…

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms Open

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts , et al. · 2020

How lethal coronaviruses engage hosts Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts …

Lipid Nanodiscs via Ordered Copolymers Open

Anton A. A. Smith, Henriette Elisabeth Autzen, Bryan Faust, Joseph L. Mann, Benjamin W. Muir , et al. · 2020

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation Open

Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica V. Rezelj , et al. · 2020

Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host …

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization v1 Open

Bei Wang, Daniel Asarnow, Wen-Hsin Lee, Ching-Wen Huang, Bryan Faust , et al. · 2020

In vitro antibody selection against pathogens from naïve combinatorial libraries can yield various classes of antigen-specific binders that are distinct from those evolved from natural infection. Also, rapid neutralizing antibody discovery…

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