Bryan G. Yipp
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View article: Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon‐Based Liquid Ventilation With Tissue Clearing for Deep‐Tissue Imaging
Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon‐Based Liquid Ventilation With Tissue Clearing for Deep‐Tissue Imaging Open
Intravital lung imaging has been employed to study physiological and pathophysiological processes related to nanoparticle deposition in the alveolar lung, particularly in the context of air pollution and drug delivery. However, optical ima…
View article: Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus Open
View article: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus Open
Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike host resistance, the mechanisms underlying disease tolerance remain poorly unders…
View article: A vascularized human lung-on-a-chip reveals compartmentalized inflammatory responses in bacterial pneumonia
A vascularized human lung-on-a-chip reveals compartmentalized inflammatory responses in bacterial pneumonia Open
The lung serves as a primary organ for gas exchange in the human body. However, during clinically apparent lung insults such as bacterial pneumonia, the blood-alveolar barrier is disrupted, immune cells are recruited, and lung biomechanics…
View article: β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A Virus
β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A Virus Open
Disease tolerance is an evolutionarily conserved host defence strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike host resistance, the mechanisms underlying disease tolerance remain poorly unders…
View article: Vagal TRPV1<sup>+</sup>sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection
Vagal TRPV1<sup>+</sup>sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection Open
Influenza viruses are a major global cause of morbidity and mortality. Vagal TRPV1 + nociceptive sensory neurons, which innervate the airways, are known to mediate defenses against harmful agents. However, their function in lung antiviral …
View article: Endotyping in ARDS: one step forward in precision medicine
Endotyping in ARDS: one step forward in precision medicine Open
View article: Neutrophil swarming: Is a good offense the best defense?
Neutrophil swarming: Is a good offense the best defense? Open
The phenomenon of swarming has long been observed in nature as a strategic event that serves as a good offense toward prey and predators. Imaging studies have uncovered that neutrophils employ this swarm-like tactic within infected and inf…
View article: Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy
Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy Open
Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with CyC's systemic regul…
View article: Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk
Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk Open
During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms regulating this crucial response are unknown. Using in vivo imaging of neutroph…
View article: Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A)
Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A) Open
Despite surviving a SARS-CoV-2 infection, some individuals experience an intense post-infectious Multisystem Inflammatory Syndrome (MIS) of uncertain etiology. Children with this syndrome (MIS-C) can experience a Kawasaki-like disease, but…
View article: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE Open
View article: Inflammatory platelet death drives sepsis
Inflammatory platelet death drives sepsis Open
View article: Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 Open
While critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during COVID-19 ARDS, compared to ARDS from other respiratory pathogens, is unclear. Mor…
View article: Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 Open
While critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during COVID-19 ARDS, compared to ARDS from other respiratory pathogens, is unclear. Mor…
View article: Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 Open
While critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during COVID-19 ARDS, compared to ARDS from other respiratory pathogens, is unclear. Mor…
View article: Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging
Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging Open
The lungs are constantly exposed to non-sterile air which carries harmful threats, such as particles and pathogens. Nonetheless, this organ is equipped with fast and efficient mechanisms to eliminate these threats from the airways as well …
View article: A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies Open
Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome, constituted by respiratory failure and diffuse alveolar damage that results from dysregulated local and systemic immune activation, causing pulmonary vascular, pare…
View article: Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 Open
View article: Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy
Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy Open
Summary Cystatin C (CyC) is a secreted cysteine protease inhibitor and its biological functions remain insufficiently characterized. Plasma CyC is elevated in many patients, especially when receiving glucocorticoid (GC) treatment. Endogeno…
View article: Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia
Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia Open
Pulmonary innate immunity is required for host defense; however, excessive neutrophil inflammation can cause life-threatening acute lung injury. B lymphocytes can be regulatory, yet little is known about peripheral transitional IgM+ B cell…
View article: PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections Open
Human rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower airways diseases. Although viral induced epithelial damage mediates inflammation, the molecular mechanisms responsible for airway epithelial damage and…
View article: A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies Open
Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome of respiratory failure and diffuse alveolar damage that results from dysregulated local and systemic immune activation, causing pulmonary vascular, parenchymal and a…
View article: Multi-Omics Reveal Rhinovirus Strain-Specific Metabolic Signatures in Highly Differentiated Human Airway Epithelial Cells
Multi-Omics Reveal Rhinovirus Strain-Specific Metabolic Signatures in Highly Differentiated Human Airway Epithelial Cells Open
View article: An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy
An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy Open
Summary SARS-CoV-2 is a novel coronavirus that causes acute respiratory distress syndrome (ARDS), death and long-term sequelae. Innate immune cells are critical for host defense but are also the primary drivers of ARDS. The relationships b…
View article: Bacterial cyclic diguanylate signaling networks sense temperature
Bacterial cyclic diguanylate signaling networks sense temperature Open
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates temperature-dependent motility, biofilm…
View article: SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients Open
Summary In late 2019 a novel coronavirus (SARS-CoV-2) emerged, and has since caused a global pandemic. Understanding the pathogenesis of COVID-19 disease is necessary to inform development of therapeutics, and management of infected patien…
View article: Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 Open
While critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during COVID-19 ARDS, compared to ARDS from other respiratory pathogens, is unclear. Mor…
View article: An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amendable to Therapy
An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amendable to Therapy Open
SARS-CoV-2 is a novel coronavirus that causes acute respiratory distress syndrome (ARDS) and death. Innate immune cells are critical for host defense but are also the primary drivers of acute respiratory distress syndrome. The relationship…
View article: An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amendable to Therapy
An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amendable to Therapy Open
SARS-CoV-2 is a novel coronavirus that causes acute respiratory distress syndrome (ARDS) and death. Innate immune cells are critical for host defense but are also the primary drivers of acute respiratory distress syndrome. The relationship…