Bryan Haddock
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View article: Glucose-dependent Insulinotropic Polypeptide is Involved in Postprandial Regulation of Splanchnic Blood Supply
Glucose-dependent Insulinotropic Polypeptide is Involved in Postprandial Regulation of Splanchnic Blood Supply Open
Gastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution as well. In a randomized cross-over design in 10 healthy men, the involvement of glucose-de…
View article: Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply
Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply Open
Gastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution. In a randomized cross-over design in 10 healthy men, the involvement of glucose-dependent …
View article: Glucose-dependent Insulinotropic Polypeptide is Involved in Postprandial Regulation of Splanchnic Blood Supply
Glucose-dependent Insulinotropic Polypeptide is Involved in Postprandial Regulation of Splanchnic Blood Supply Open
Gastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution as well. In a randomized cross-over design in 10 healthy men, the involvement of glucose-de…
View article: Feasibility of replacing <scp><sup>99m</sup>Tc</scp>‐<scp>DTPA GFR</scp> measurements with <scp>eGFR</scp> from cystatin C in individuals with spinal cord injuries
Feasibility of replacing <span><sup>99m</sup>Tc</span>‐<span>DTPA GFR</span> measurements with <span>eGFR</span> from cystatin C in individuals with spinal cord injuries Open
In individuals with spinal cord injury (SCI) and neurogenic bladder dysfunction, guidelines recommend regular monitoring of kidney function by measuring the glomerular filtration rate using an externally administered filtration markers suc…
View article: Automating Imaging Biomarker Analysis for Knee Osteoarthritis Using an Open-Source MRI-Based Deep Learning Pipeline
Automating Imaging Biomarker Analysis for Knee Osteoarthritis Using an Open-Source MRI-Based Deep Learning Pipeline Open
Osteoarthritis (OA) is a leading cause of chronic disability worldwide, with knee OA being the most prevalent form. Quantitative assessment of knee joint tissues using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET)…
View article: High agreement between lean mass assessed by Dual-Energy X-ray absorptiometry and Bioelectrical Impedance Analysis across the adult lifespan
High agreement between lean mass assessed by Dual-Energy X-ray absorptiometry and Bioelectrical Impedance Analysis across the adult lifespan Open
Background Bioelectrical impedance analysis (BIA) is considered a portable alternative to Dual-energy X-ray absorptiometry (DXA) when assessing deficient muscle mass, a major concern for older adults associated with increased risks of fall…
View article: Automated Quantitative Image-Derived Input Function for the Estimation of Cerebral Blood Flow Using Oxygen-15-Labelled Water on a Long-Axial Field-of-View PET/CT Scanner
Automated Quantitative Image-Derived Input Function for the Estimation of Cerebral Blood Flow Using Oxygen-15-Labelled Water on a Long-Axial Field-of-View PET/CT Scanner Open
The accurate estimation of the tracer arterial blood concentration is crucial for reliable quantitative kinetic analysis in PET. In the current work, we demonstrate the automatic extraction of an image-derived input function (IDIF) from a …
View article: Multimodality Imaging in Cranial Giant Cell Arteritis: First Experience with High-Resolution T1-Weighted 3D Black Blood without Contrast Enhancement Magnetic Resonance Imaging
Multimodality Imaging in Cranial Giant Cell Arteritis: First Experience with High-Resolution T1-Weighted 3D Black Blood without Contrast Enhancement Magnetic Resonance Imaging Open
In order to support or refute the clinical suspicion of cranial giant cell arteritis (GCA), a supplemental imaging modality is often required. High-resolution black blood Magnetic Resonance Imaging (BB MRI) techniques with contrast enhance…
View article: Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee
Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee Open
Introduction Accurately estimating bone perfusion and metabolism using [ 18 F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of chan…
View article: Age‐ and sex‐specific changes in visceral fat mass throughout the life‐span
Age‐ and sex‐specific changes in visceral fat mass throughout the life‐span Open
Objective Visceral fat mass (VFM) is a risk factor for cardiovascular diseases, type 2 diabetes mellitus, and malignancy; however, normative data are limited. The aim of this study was to provide reference data for VFM from a large, appare…
View article: Evaluation of the effects of ezetimibe on albuminuria and kidney fat in individuals with type 2 diabetes and chronic kidney disease
Evaluation of the effects of ezetimibe on albuminuria and kidney fat in individuals with type 2 diabetes and chronic kidney disease Open
Aim To investigate the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney‐PF) in individuals with type 2 diabetes (T2D) and early chronic kidney disease. Materials and Methods A rand…
View article: Multiparametric magnetic resonance imaging: A robust tool to test pathogenesis and pathophysiology behind nephropathy in humans
Multiparametric magnetic resonance imaging: A robust tool to test pathogenesis and pathophysiology behind nephropathy in humans Open
Chronic kidney disease (CKD) is a major population disease. In diabetes as well as hypertension, kidney disease is one of the most serious complications. Recent research has demonstrated that chronic hypoxia is a key actor in the pathogene…
View article: GLP−1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading
GLP−1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading Open
Background GLP‐1 (glucagon‐like peptide‐1) receptor agonists exert beneficial long‐term effects on cardiovascular and renal outcomes. In humans, the natriuretic effect of GLP‐1 depends on GLP‐1 receptor interaction, is accompanied by suppr…
View article: Age- and Sex-Specific Changes in visceral fat mass Throughout the Lifespan
Age- and Sex-Specific Changes in visceral fat mass Throughout the Lifespan Open
Background High visceral fat mass (VFM) is a risk factor for cardiovascular diseases, type 2 diabetes mellitus and malignancy, however, normative data are limited. The aim of this study was to provide reference data for VFM from a large ap…
View article: Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes Open
Background We used magnetic resonance imaging (MRI) to study kidney energetics in persons with and without type 1 diabetes (T1D). Methods In a cross-sectional study, 15 persons with T1D and albuminuria and 15 non-diabetic controls (CONs) u…
View article: Kidney segmentation for quantitative analysis applying MaskRCNN architecture
Kidney segmentation for quantitative analysis applying MaskRCNN architecture Open
Results of applying the deep learning Mask Regional Convolutional Neural Network (MaskRCNN) to the problem of segmenting human kidney and delineating the kidney tissue into the 12 classes left/right kidney, cortex, medulla 1, 2, 3, 4 are p…
View article: Associations between inflammatory markers, body composition, and physical function: the Copenhagen Sarcopenia Study
Associations between inflammatory markers, body composition, and physical function: the Copenhagen Sarcopenia Study Open
Background Chronic low‐grade inflammation has been suggested as one of the key elements in the development of sarcopenia, but in contrast to disease‐related loss of muscle mass, the role of chronic low‐grade inflammation in age‐related (pr…
View article: Changes in systemic GDF15 across the adult lifespan and their impact on maximal muscle power: the Copenhagen Sarcopenia Study
Changes in systemic GDF15 across the adult lifespan and their impact on maximal muscle power: the Copenhagen Sarcopenia Study Open
Background Although growth differentiation factor 15 (GDF15) is known to increase with disease and is associated with low physical performance, the role of GDF15 in normal ageing is still not fully understood. Specifically, the influence o…
View article: Assessment of functional sit-to-stand muscle power: Cross-sectional trajectories across the lifespan
Assessment of functional sit-to-stand muscle power: Cross-sectional trajectories across the lifespan Open
The STS muscle power test appears to provide a feasible and inexpensive tool to monitor cross-sectional trajectories of muscle power throughout the lifespan.
View article: Exercise-induced fluid shifts are distinct to exercise mode and intensity: a comparison of blood flow-restricted and free-flow resistance exercise
Exercise-induced fluid shifts are distinct to exercise mode and intensity: a comparison of blood flow-restricted and free-flow resistance exercise Open
Using muscle functional MRI (mfMRI), this study was able to differentiate the acute physiological responses following three established hypertrophic resistance exercise strategies. Low-load exercise protocols performed to failure, with or …
View article: Consensus‐Based Technical Recommendations for Clinical Translation of Renal Phase Contrast <scp>MRI</scp>
Consensus‐Based Technical Recommendations for Clinical Translation of Renal Phase Contrast <span>MRI</span> Open
Background Phase‐contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood …
View article: Relation between leg extension power and 30-s sit-to-stand muscle power in older adults: validation and translation to functional performance
Relation between leg extension power and 30-s sit-to-stand muscle power in older adults: validation and translation to functional performance Open
This study aimed to assess the validity and functional relevance of a standardized procedure to assess lower limb muscle power by means of the 30-s sit-to-stand (STS) test when compared to leg extension power (LEP), traditional STS perform…
View article: Physiological responses of human skeletal muscle to acute blood flow restricted exercise assessed by multimodal MRI
Physiological responses of human skeletal muscle to acute blood flow restricted exercise assessed by multimodal MRI Open
Acute changes in blood flow, diffusion, blood oxygenation, cross-sectional area, and the “T 2 shift” are evaluated in human skeletal muscle in response to blood flow-restricted (BFR) and conventional free-flow knee extensor exercise perfor…