Bryan J. Venters
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View article: Nucleosome context regulates chromatin reader preference
Nucleosome context regulates chromatin reader preference Open
Chromatin is more than a simple genome packaging system but rather locally distinguished by histone post-translational modifications (PTMs) that can directly change nucleosome structure and/or be “read” by chromatin-associated proteins to …
View article: Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage Open
Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought to contribute to their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show …
View article: Nucleosome context regulates chromatin reader preference
Nucleosome context regulates chromatin reader preference Open
Chromatin is more than a simple genome packaging system, and instead locally distinguished by histone post-translational modifications (PTMs) that can directly change nucleosome structure and / or be “read” by chromatin-associated proteins…
View article: The common murine retroviral integration site activating Hhex marks a distal regulatory enhancer co-opted in human early T-cell precursor leukemia
The common murine retroviral integration site activating Hhex marks a distal regulatory enhancer co-opted in human early T-cell precursor leukemia Open
The Hhex gene encodes a transcription factor that is important for both embryonic and post-natal development, especially of hematopoietic tissues. Hhex is one of the most common sites of retroviral integration in mouse models. We found the…
View article: High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN
High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN Open
The precise regulation of chromatin composition is critical to gene expression and cellular identity, and thus a key component in development and disease. Robust assays to study chromatin features, including histone post-translational modi…
View article: Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch Open
During tumor development, promoter CpG islands that are normally silenced by Polycomb repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by which de novo DNA methyltransferase(s) [DNMT(s)] catalyze CpG methylat…
View article: Emerging Approaches to Profile Accessible Chromatin from Formalin-Fixed Paraffin-Embedded Sections
Emerging Approaches to Profile Accessible Chromatin from Formalin-Fixed Paraffin-Embedded Sections Open
Nucleosomes are non-uniformly distributed across eukaryotic genomes, with stretches of ‘open’ chromatin strongly associated with transcriptionally active promoters and enhancers. Understanding chromatin accessibility patterns in normal tis…
View article: Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch
Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch Open
During tumor development, promoter CpG islands (CGIs) that are normally silenced by Polycomb repressive complexes (PRCs) become DNA hypermethylated. The molecular mechanism by which de novo DNA methyltransferase(s) catalyze CpG methylation…
View article: Emerging Approaches to Profile Accessible Chromatin from Ffpe Sections
Emerging Approaches to Profile Accessible Chromatin from Ffpe Sections Open
Nucleosomes are non-uniformly distributed across eukarytic genomes, with stretches of ‘open’ chromatin strongly associated with transcriptionally active promoters and enhancers. Understanding chromatin accessibility patterns in normal tiss…
View article: Nucleosome conformation dictates the histone code
Nucleosome conformation dictates the histone code Open
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin-associated protein…
View article: SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation Open
View article: SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion Open
View article: Author response: Nucleosome conformation dictates the histone code
Author response: Nucleosome conformation dictates the histone code Open
View article: Nucleosome conformation dictates the histone code
Nucleosome conformation dictates the histone code Open
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin associated protein…
View article: A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells
A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells Open
Antibodies offer a powerful means to interrogate specific proteins in a complex milieu. However, antibody availability and reliability can be problematic, whereas epitope tagging can be impractical in many cases. To address these limitatio…
View article: Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture Open
View article: Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-established Chromatin Architecture
Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-established Chromatin Architecture Open
The three-dimensional architecture of the genome plays an essential role in establishing and maintaining cell identity. However, the magnitude and temporal kinetics of changes in chromatin structure that arise during cell differentiation r…
View article: Erythropoietin regulates transcription and YY1 dynamics in a pre-established chromatin architecture
Erythropoietin regulates transcription and YY1 dynamics in a pre-established chromatin architecture Open
The three dimensional architecture of the genome plays an essential role in establishing and maintaining cell identity. By contrast, the magnitude and temporal kinetics of changes in chromatin structure that arise during cell differentiati…
View article: Ldb1 is required for Lmo2 oncogene–induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia
Ldb1 is required for Lmo2 oncogene–induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia Open
Prolonged or enhanced expression of the proto-oncogene Lmo2 is associated with a severe form of T-cell acute lymphoblastic leukemia (T-ALL), designated early T-cell precursor ALL, which is characterized by the aberrant self-renewal and sub…
View article: Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-Established Chromatin Architecture
Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-Established Chromatin Architecture Open
View article: p73 regulates epidermal wound healing and induced keratinocyte programming
p73 regulates epidermal wound healing and induced keratinocyte programming Open
p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal cells and can h…
View article: Epigenetic and transcriptional profiling of triple negative breast cancer
Epigenetic and transcriptional profiling of triple negative breast cancer Open
View article: Data Citation 1
Data Citation 1 Open
Gene RPKM analysis for PRO-seq and ChIP-exo data
View article: Data Citation 1
Data Citation 1 Open
Gene RPKM analysis for PRO-seq and ChIP-exo data
View article: p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion
p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion Open
View article: ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells
ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells Open
View article: Table of gene RPKM analysis for ChIP-seq and ChIP-exo data.
Table of gene RPKM analysis for ChIP-seq and ChIP-exo data. Open
Table of gene RPKM analysis for ChIP-seq and ChIP-exo data.
View article: Insights from resolving protein–DNA interactions at near base-pair resolution
Insights from resolving protein–DNA interactions at near base-pair resolution Open
One of the central goals in molecular biology is to understand how cell-type-specific expression patterns arise through selective recruitment of RNA polymerase II (Pol II) to a subset of gene promoters. Pol II needs to be recruited to a pr…
View article: Epo reprograms the epigenome of erythroid cells
Epo reprograms the epigenome of erythroid cells Open
View article: High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML
High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML Open